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J-GLOBAL ID：201902289474821566   Reference number：19A1042149

LPA Induces Keratinocyte Differentiation and Promotes Skin Barrier Function through the LPAR1/LPAR5-RHO-ROCK-SRF Axis

LPAはケラチン細胞分化を誘導し,LPAR1/LPAR5-Rho-ROCK-SRFAxisを介して皮膚バリア機能を促進する【JST・京大機械翻訳】

Author (17)： Sumitomo Akiko (Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Siriwach Ratklao (Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Siriwach Ratklao (Department of Drug Discovery Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Thumkeo Dean (Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Thumkeo Dean (Department of Drug Discovery Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Ito Kentaro (Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Nakagawa Ryota (Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Tanaka Nobuo (Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Tanabe Kohei (Department of Drug Discovery Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Watanabe Akira (Center for iPS Cell Research, Kyoto University, Kyoto, Japan) ,  Kishibe Mari (Department of Dermatology, Asahikawa Medical University, Hokkaido, Japan) ,  Ishida-Yamamoto Akemi (Department of Dermatology, Asahikawa Medical University, Hokkaido, Japan) ,  Honda Tetsuya (Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Kabashima Kenji (Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Aoki Junken (Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, Japan) ,  Narumiya Shuh (Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Narumiya Shuh (Department of Drug Discovery Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan)
Material： Journal of Investigative Dermatology  (J Invest Dermatol)
Volume： 139  Issue： 5 S  Page： 1010-1022  Publication year： 2019 
JST Material Number： H0776A  ISSN： 0022-202X  CODEN： JIDEAE  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The skin barrier protects the ...

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Thesaurus term： homeostasis ,  lysophosphatidic acid ,  *differentiation (biology) ,  Mus musculus ,  *keratinocyte ,  atopic dermatitis ,  human ,  *keratin ,  monomer ,  gene ,  natural moisturizing factor ,  *barrier function ,  Filaggrin Proteins ,  Signal Transduction ,  Myomorpha ,  *animal protein
Semi thesaurus term： cellular signal transduction ,  *皮膚バリアー機能 , 【Automatic Indexing@JST】

JST classification (3)： Integument in general  (EJ11010C) ,  Cell physiology in general  (EF02010S) ,  Gene expression  (EC02040Q)

Terms in the title (6)： ケラチン細胞 ,  分化 ,  誘導 ,  ROCK ,  皮膚バリア機能 ,  促進