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J-GLOBAL ID：201902290153008755   Reference number：19A2162049

Endoplasmic reticulum stress-induced iRhom2 up-regulation promotes macrophage-regulated cardiac inflammation and lipid deposition in high fat diet (HFD)-challenged mice: Intervention of fisetin and metformin

高脂肪食(HFD)-攻撃マウスにおいて小胞体ストレス誘導性のIRHOM2アップレギュレーションはマクロファージ調節性の心臓炎症と脂質沈着を促進する:フィセチンとメトホルミンの介入【JST・京大機械翻訳】

Author (15)： Ge Chen-Xu (Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, 400067, PR China) ,  Ge Chen-Xu (Research Center of Brain Intellectual Promotion and Development for Children Aged 0-6 Years, Chongqing University of Education, Chongqing, 400067, PR China) ,  Xu Min-Xuan (Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, 400067, PR China) ,  Xu Min-Xuan (Research Center of Brain Intellectual Promotion and Development for Children Aged 0-6 Years, Chongqing University of Education, Chongqing, 400067, PR China) ,  Qin Yu-Ting (School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100, PR China) ,  Gu Ting-Ting (College of Engineering and Applied Sciences, Nanjing University, Nanjing, 210023, PR China) ,  Lou De-Shuai (Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, 400067, PR China) ,  Lou De-Shuai (Research Center of Brain Intellectual Promotion and Development for Children Aged 0-6 Years, Chongqing University of Education, Chongqing, 400067, PR China) ,  Li Qiang (Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, 400067, PR China) ,  Li Qiang (Research Center of Brain Intellectual Promotion and Development for Children Aged 0-6 Years, Chongqing University of Education, Chongqing, 400067, PR China) ,  Hu Lin-Feng (Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, 400067, PR China) ,  Hu Lin-Feng (Research Center of Brain Intellectual Promotion and Development for Children Aged 0-6 Years, Chongqing University of Education, Chongqing, 400067, PR China) ,  Wang Bo-Chu (Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400030, China) ,  Tan Jun (Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, 400067, PR China) ,  Tan Jun (Research Center of Brain Intellectual Promotion and Development for Children Aged 0-6 Years, Chongqing University of Education, Chongqing, 400067, PR China)
Material： Free Radical Biology & Medicine  (Free Radical Biology and Medicine)
Volume： 141  Page： 67-83  Publication year： 2019 
JST Material Number： D0414C  ISSN： 0891-5849  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Endoplasmic reticulum stress (...

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Thesaurus term： *macrophage ,  pathogenesis ,  antioxidation ,  cardiomyopathy ,  *inflammation ,  obesity ,  *deposition ,  *lipid ,  *up-regulation ,  dysfunction ,  oxidative stress ,  cellular signal transduction ,  *heart ,  aliphatic amine ,  oxygen heterocyclic compound ,  polyphenol ,  flavonoid ,  polynuclear aromatic compound ,  hydroxy ketone

Author keywords (5)： Obesity ,  Cardiomyopathy ,  Inflammation ,  Lipid deposition ,  ROS/ERS/iRhom2

JST classification (3)： Cell physiology in general  (EF02010S) ,  Basic medicine on cardiovascular system  (GJ01020K) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Substance index (2)： Metformin ,  Fisetin

Terms in the title (14)： 高脂肪食 ,  攻撃 ,  マウス ,  小胞体ストレス ,  アップレギュレーション ,  マクロファージ ,  調節 ,  心臓 ,  炎症 ,  脂質 ,  沈着 ,  促進 ,  フィセチン ,  メトホルミン