Art

J-GLOBAL ID：201902290544783561   Reference number：19A1667622

Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids

ヒト結腸オルガノイドを用いた潰瘍性大腸炎に対する治験薬の治療効果と動態を評価するシステムの確立

Author (10)： Nishimura Ryu (Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan) ,  Shirasaki Tomoaki (Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan) ,  Tsuchiya Kiichiro (Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan) ,  Miyake Yoshihide (Pharmacology Department, Drug Research Center, Kaken Pharmaceutical Co., Ltd, Kyoto, Japan) ,  Watanabe Yusuke (Pharmacology Department, Drug Research Center, Kaken Pharmaceutical Co., Ltd, Kyoto, Japan) ,  Hibiya Shuji (Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan) ,  Watanabe Sho (Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan) ,  Nakamura Tetsuya (Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan) ,  Nakamura Tetsuya (Department of Advanced Therapeutics for Gastrointestinal Diseases, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan) ,  Watanabe Mamoru (Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan)
Material： Journal of Gastroenterology (Web)
Volume： 54  Issue： 7  Page： 608-620  Publication year： 2019 
JST Material Number： U1592A  ISSN： 0944-1174  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： *new drug development ,...

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Author keywords (4)： Inflammatory bowel disease ,  In vitro human model ,  Evaluation system ,  Investigational drug

JST classification (3)： Basic medicine on digestive system  (GH01020E) ,  Cell and tissue culture methods  (EA03040R) ,  Basic research of drugs acting on digestive system  (GW09010Q)

Substance index (1)： KAG-308

Terms in the title (7)： ヒト ,  結腸 ,  オルガノイド ,  潰瘍性大腸炎 ,  治験薬 ,  治療効果 ,  評価