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J-GLOBAL ID：201902291698979514   Reference number：19A2679303

Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice

SETD1A欠損マウスにおける統合失調症関連表現型の再捕獲と逆転【JST・京大機械翻訳】

Author (19)： Mukai Jun (Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA) ,  Mukai Jun (Mortimer B. Zuckerman Mind Brain and Behavior Institute Columbia University, New York, NY 10027, USA) ,  Cannavo Enrico (Mortimer B. Zuckerman Mind Brain and Behavior Institute Columbia University, New York, NY 10027, USA) ,  Crabtree Gregg W. (Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA) ,  Crabtree Gregg W. (Mortimer B. Zuckerman Mind Brain and Behavior Institute Columbia University, New York, NY 10027, USA) ,  Sun Ziyi (Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA) ,  Diamantopoulou Anastasia (Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA) ,  Thakur Pratibha (Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA) ,  Thakur Pratibha (Mortimer B. Zuckerman Mind Brain and Behavior Institute Columbia University, New York, NY 10027, USA) ,  Chang Chia-Yuan (Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA) ,  Cai Yifei (Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA) ,  Lomvardas Stavros (Mortimer B. Zuckerman Mind Brain and Behavior Institute Columbia University, New York, NY 10027, USA) ,  Lomvardas Stavros (Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA) ,  Lomvardas Stavros (Department of Neuroscience, Columbia University, New York, NY 10032, USA) ,  Takata Atsushi (Department of Human Genetics, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Xu Bin (Department of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA) ,  Gogos Joseph A. (Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA) ,  Gogos Joseph A. (Mortimer B. Zuckerman Mind Brain and Behavior Institute Columbia University, New York, NY 10027, USA) ,  Gogos Joseph A. (Department of Neuroscience, Columbia University, New York, NY 10032, USA)
Material： Neuron
Volume： 104  Issue： 3  Page： 471-487.e12  Publication year： 2019 
JST Material Number： T0649A  ISSN： 0896-6273  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： SETD1A, a lysine-methyltransfe...

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Thesaurus term： *Phenotype ,  human ,  *Mus musculus ,  methyltransferase ,  Up-Regulation ,  *schizophrenia ,  promoter (genetics) ,  axon ,  cortex ,  Mutation ,  synapse ,  therapy ,  Down-Regulation ,  lysine demethylase 1 ,  Cognition Disorders ,  Nerve ,  *Myomorpha

Author keywords (10)： SETD1A ,  MEF2 ,  LSD1 ,  histone methyltransferase ,  enhancer ,  loss-of-function mutation ,  schizophrenia ,  axonal branching ,  working memory ,  pharmacological reversal

JST classification (1)： Central nervous system  (EJ12030F)

Terms in the title (6)： 欠損 ,  マウス ,  統合失調症 ,  表現型 ,  捕獲 ,  逆転