Art

J-GLOBAL ID：201902291703673716   Reference number：19A0217238

Enhancement Effect of Poly-L-ornithine on the Nasal Absorption of Water-Soluble Macromolecules in Rats

ラットにおける水溶性高分子の鼻吸収に対するポリ-L-オルニチンの増強効果

Author (8)： Omori Shigehiro (Faculty of Pharmacy and Pharmaceutical Sciences, Josai University) ,  Kamiya Yusuke (Faculty of Pharmacy and Pharmaceutical Sciences, Josai University) ,  Kamiya Yusuke (Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University) ,  Yamaki Tsutomu (Faculty of Pharmacy and Pharmaceutical Sciences, Josai University) ,  Uchida Masaki (Faculty of Pharmacy and Pharmaceutical Sciences, Josai University) ,  Ohtake Kazuo (Faculty of Pharmacy and Pharmaceutical Sciences, Josai University) ,  Kimura Mitsutoshi (Faculty of Pharmacy and Pharmaceutical Sciences, Josai University) ,  Natsume Hideshi (Faculty of Pharmacy and Pharmaceutical Sciences, Josai University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 1  Page： 144-148(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Rattus ,...
Semi thesaurus term： *polycation ,...

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Author keywords (8)： poly-L-ornithine (PLO) ,  nasal absorption ,  enhancement effect ,  molecular weight ,  poly-L-ornithine (PLO) ,  nasal absorption ,  enhancement effect ,  molecular weight

JST classification (1)： Basic biopharmacy  (GY01021U)

Substance index (1)： Ornithine

Reference (23)：

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• 5) McMartin C, Hutchinson LEF, Hyde R, Peters GE. Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity. J. Pharm. Sci., 76, 535-540 (1987).

Terms in the title (5)： ラット ,  水溶性高分子 ,  鼻吸収 ,  L-オルニチン ,  増強