Art

J-GLOBAL ID：201902291883546756   Reference number：19A1349617

Trans-Ethnic Polygenic Analysis Supports Genetic Overlaps of Lumbar Disc Degeneration With Height, Body Mass Index, and Bone Mineral Density

高身長,ボディマスインデックスおよび骨ミネラル密度による腰椎椎間板変性の遺伝的重複をサポートするトランス-民族多遺伝子解析【JST・京大機械翻訳】

Author (22)： Zhou Xueya (Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong) ,  Zhou Xueya (Department of Systems Biology, Department of Pediatrics, Columbia University Medical Center, New York, NY, United States) ,  Cheung Ching-Lung (Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong) ,  Cheung Ching-Lung (Li Ka Shing Faculty of Medicine, Center for Genomic Sciences, The University of Hong Kong, Hong Kong, Hong Kong) ,  Karasugi Tatsuki (Department of Orthopaedic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto City, Japan) ,  Karppinen Jaro (Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland) ,  Samartzis Dino (Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong) ,  Hsu Yi-Hsiang (Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, United States) ,  Hsu Yi-Hsiang (Harvard Medical School, Boston, MA, United States) ,  Hsu Yi-Hsiang (Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, MA, United States) ,  Mak Timothy Shin-Heng (Li Ka Shing Faculty of Medicine, Center for Genomic Sciences, The University of Hong Kong, Hong Kong, Hong Kong) ,  Song You-Qiang (Li Ka Shing Faculty of Medicine, Center for Genomic Sciences, The University of Hong Kong, Hong Kong, Hong Kong) ,  Song You-Qiang (Li Ka Shing Faculty of Medicine, School of Biomedical Science, The University of Hong Kong, Hong Kong, Hong Kong) ,  Chiba Kazuhiro (Department of Orthopedic Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan) ,  Kawaguchi Yoshiharu (Department of Orthopaedic Surgery, Toyama University, Toyama Prefecture, Japan) ,  Li Yan (Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong) ,  Chan Danny (Li Ka Shing Faculty of Medicine, School of Biomedical Science, The University of Hong Kong, Hong Kong, Hong Kong) ,  Cheung Kenneth Man-Chee (Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong) ,  Ikegawa Shiro (Laboratory of Bone and Joint Diseases, Center for Integrative Medical Sciences, RIKEN, Tokyo, Japan) ,  Cheah Kathryn Song-Eng (Li Ka Shing Faculty of Medicine, School of Biomedical Science, The University of Hong Kong, Hong Kong, Hong Kong) ,  Sham Pak Chung (Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong) ,  Sham Pak Chung (Li Ka Shing Faculty of Medicine, Center for Genomic Sciences, The University of Hong Kong, Hong Kong, Hong Kong)
Material： Frontiers in Genetics (Web)
Volume： 9  Page： 267  Publication year： 2018 
JST Material Number： U7071A  ISSN： 1664-8021  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Lumbar disc degeneration (LDD)...

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Thesaurus term： Causality ,  allele ,  *height (body) ,  *Heredity ,  *Lumbar Vertebrae ,  pathogenesis ,  Phenotype ,  Genome-Wide Association Study ,  Europe ,  *gene ,  population (statistics) ,  NMR imaging ,  Chinese ,  *Body Mass Index ,  *degree of obesity
Semi thesaurus term： *body mass index ,  スコア , 【Automatic Indexing@JST】

Author keywords (6)： polygenic score ,  genetic correlation ,  causality ,  pleiotropy ,  lumbar disc degeneration ,  osteoarthritis

JST classification (1)： Genetic variation  (EC01030Y)

Reference (102)：

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• Arden N. K., Griffiths G. O., Hart D. J., Doyle D. V., Spector T. D. (1996). The association between osteoarthritis and osteoporotic fracture: the Chingford Study. Br. J. Rheumatol. 35, 1299-1304. doi: 10.1093/rheumatology/35.12.1299
• Battié M. C., Videman T., Levälahti E., Gill K., Kaprio J. (2008). Genetic and environmental effects on disc degeneration by phenotype and spinal level: a multivariate twin study. Spine 33, 2801-2808. doi: 10.1097/BRS.0b013e31818043b7
• Battié M. C., Videman T., Parent E. (2004). Lumbar disc degeneration: epidemiology and genetic influences. Spine 29, 2679-2690. doi: 10.1097/01.brs.0000146457.83240.eb
• Bierma-Zeinstra S. M., Koes B. W. (2007). Risk factors and prognostic factors of hip and knee osteoarthritis. Nat. Clin. Pract. Rheumatol. 3, 78-85. doi: 10.1038/ncprheum0423

Terms in the title (8)： 高身長 ,  ボディマスインデックス ,  骨ミネラル密度 ,  腰椎 ,  椎間板変性 ,  トランス ,  民族 ,  遺伝子解析