Art

J-GLOBAL ID：201902292113312892   Reference number：19A1899362

Transcriptional Repression of CYP3A4 by Increased miR-200a-3p and miR-150-5p Promotes Steatosis in vitro

miR-200a-3pとmiR-150-5pの増加によるCYP3A4の転写抑制はin vitroで脂肪症を促進する【JST・京大機械翻訳】

Author (14)： Huang Zhijun (Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China) ,  Huang Zhijun (Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China) ,  Wang Mengyao (Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China) ,  Wang Mengyao (Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China) ,  Liu Li (Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China) ,  Peng Jinfu (Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China) ,  Peng Jinfu (Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China) ,  Guo Chengxian (Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China) ,  Chen Xiaoping (Institute of Clinical Pharmacology, Central South University, Changsha, China) ,  Huang Lu (Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China) ,  Huang Lu (Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China) ,  Tan Jieqiong (Center for Medical Genetics, Life Science School, Central South University, Changsha, China) ,  Yang Guoping (Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China) ,  Yang Guoping (Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China)
Material： Frontiers in Genetics (Web)
Volume： 10  Page： 484  Publication year： 2019 
JST Material Number： U7071A  ISSN： 1664-8021  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Hepatic cytochrome P450 enzyme...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=19A1899362&from=J-GLOBAL&jstjournalNo=U7071A") }}

Thesaurus term： variation(biology) ,  targeting ,  interaction ,  fatty liver ,  free fatty acid ,  binding site ,  algorithm ,  enzyme activity ,  *in vitro experiment
Semi thesaurus term： 内因性 ,  阻害剤 ,  マイクロRNA ,  非翻訳領域 ,  ルシフェラーゼアッセイ ,  *脂肪過剰 , 【Automatic Indexing@JST】

Author keywords (5)： non-alcoholic fatty liver disease ,  CYP3A4 ,  miR-200a-3p ,  miR-150-5p ,  LO2 cell line

JST classification (2)： Basic neurology  (GN01020W) ,  Gene expression  (EC02040Q)

Reference (40)：

• Alisi A., Da Sacco L., Bruscalupi G., Piemonte F., Panera N., De Vito R., et al (2011). Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease. Lab Invest. 91 283-293. doi: 10.1038/labinvest.2010.166
• Anderson N., Borlak J. (2008). Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis. Pharmacol. Rev. 60 311-357. doi: 10.1124/pr.108.00001
• Anglicheau D., Legendre C., Beaune P., Thervet E. (2007). Cytochrome P450 3A polymorphisms and immunosuppressive drugs: an update. Pharmacogenomics 8 835-849. doi: 10.2217/14622416.8.7.835
• Cheung O., Puri P., Eicken C., Contos M. J., Mirshahi F., Maher J. W., et al (2008). Nonalcoholic steatohepatitis is associated with altered hepatic microRNA expression. Hepatology 48 1810-1820. doi: 10.1002/hep.22569
• Diehl A. M., Day C. (2017). Cause, pathogenesis, and treatment of nonalcoholic steatohepatitis. N. Engl. J. Med. 377 2063-2072. doi: 10.1056/nejmra1503519

Terms in the title (4)： CYP3A4 ,  転写抑制 ,  脂肪症 ,  促進