Art

J-GLOBAL ID：201902292142115541   Reference number：19A1491823

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling

ニトロ脂肪酸はウイルス感染に応答して形成され,STINGパルミトイル化とシグナル伝達の強力な阻害剤である【JST・京大機械翻訳】

Author (35)： Hansen Anne Louise (Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark) ,  Buchan Gregory J. (Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213) ,  Ruehl Michael (Department of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt am Main, Germany) ,  Mukai Kojiro (Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 113-0033 Tokyo, Japan) ,  Salvatore Sonia R. (Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213) ,  Ogawa Emari (Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 113-0033 Tokyo, Japan) ,  Andersen Sidsel D. (Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark) ,  Iversen Marie B. (Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark) ,  Thielke Anne L. (Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark) ,  Gunderstofte Camilla (Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark) ,  Motwani Mona (Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01655) ,  Moller Charlotte T. (Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark) ,  Jakobsen Andreas S. (Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark) ,  Fitzgerald Katherine A. (Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01655) ,  Roos Jessica (Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University, 60590 Frankfurt am Main, Germany) ,  Lin Rongtuan (Lady Davis Institute, Department of Medicine, McGill University, H3T 1E2 Montreal, QC, Canada) ,  Maier Thorsten J. (Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark) ,  Maier Thorsten J. (Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University, 60590 Frankfurt am Main, Germany) ,  Goldbach-Mansky Raphaela (Translational Autoinflammatory Disease Studies Unit, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20850) ,  Miner Cathrine A. (Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63110) ,  Qian Wei (Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63110) ,  Miner Jonathan J. (Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63110) ,  Miner Jonathan J. (Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110) ,  Miner Jonathan J. (Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110) ,  Rigby Rachel E. (Medical Research Council (MRC) Human Immunology Unit, University of Oxford, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, Headington, OX3 9DS Oxford, United Kingdom) ,  Rehwinkel Jan (Medical Research Council (MRC) Human Immunology Unit, University of Oxford, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, Headington, OX3 9DS Oxford, United Kingdom) ,  Jakobsen Martin R. (Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark) ,  Arai Hiroyuki (Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 113-0033 Tokyo, Japan) ,  Arai Hiroyuki (Japan Agency for Medical Research and Development (AMED)-Core Research for Evolutionary Medical Science and Technology (CREST), Japan Agency for Medical Research and Development, 100-0004 Tokyo, Japan) ,  Taguchi Tomohiko (Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 113-0033 Tokyo, Japan) ,  Taguchi Tomohiko (Laboratory of Organelle Pathophysiology, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, 980-8578 Miyagi, Japan) ,  Taguchi Tomohiko (AMED-Precursory Research for Innovative Medical Care (PRIME), Japan Agency for Medical Research and Development, 100-0004 Tokyo, Japan) ,  Schopfer Francisco J. (Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213) ,  Olagnier David (Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark) ,  Holm Christian K. (Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 115  Issue： 33  Page： E7768-E7775  Publication year： 2018 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： The adaptor molecule stimulato...

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Thesaurus term： *viral infection ,  human ,  Alkylation ,  adapter ,  Mutation ,  gene ,  interferon ,  fibroblast ,  Cytosol ,  DNA ,  *palmitoylation ,  *STING ,  *Signal Transduction
Semi thesaurus term： *cellular signal transduction ,  発症 ,  *阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： nitro-fatty acids ,  STING ,  palmitoylation ,  IFN ,  SAVI

JST classification (2)： Infectious immunity  (ED03030P) ,  Immunological reaction in general  (ED03010T)

Terms in the title (7)： 脂肪酸 ,  ウイルス感染 ,  応答 ,  STING ,  パルミトイル化 ,  シグナル伝達 ,  阻害剤