Art

J-GLOBAL ID：201902295194008950   Reference number：19A0717960

Are minor alleles more likely to be risk alleles?

マイナー対立遺伝子はリスク対立遺伝子となりうるか【JST・京大機械翻訳】

Author (15)： Kido Takashi (Rikengenesis Co., Ltd., Tokyo, Japan) ,  Kido Takashi (Preferred Networks, Inc., Tokyo, Japan) ,  Sikora-Wohlfeld Weronika (Division of Systems Medicine, Department of Pediatrics, Stanford University, Stanford, USA) ,  Kawashima Minae (Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Kikuchi Shinichi (AI System Department, DeNA, Inc., Tokyo, Japan) ,  Kamatani Naoyuki (StaGen Inc., Tokyo, Japan) ,  Patwardhan Anil (Personalis, Inc., Menlo Park, USA) ,  Chen Richard (Personalis, Inc., Menlo Park, USA) ,  Sirota Marina (Institute for Computational Health Sciences, University of California, San Francisco, USA) ,  Sirota Marina (Department of Pediatrics, University of California, San Francisco, USA) ,  Kodama Keiichi (Institute for Computational Health Sciences, University of California, San Francisco, USA) ,  Hadley Dexter (Institute for Computational Health Sciences, University of California, San Francisco, USA) ,  Hadley Dexter (Department of Pediatrics, University of California, San Francisco, USA) ,  Butte Atul J. (Institute for Computational Health Sciences, University of California, San Francisco, USA) ,  Butte Atul J. (Department of Pediatrics, University of California, San Francisco, USA)
Material： BMC Medical Genomics (Web)
Volume： 11  Issue： 1  Page： 3  Publication year： 2018 
JST Material Number： U7308A  ISSN： 1755-8794  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Genome-wide association studie...

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Thesaurus term： *Heredity ,  Heart Arrest ,  Computer Simulation ,  *allele ,  systemic lupus erythematosus ,  natural selection ,  Myopia ,  database ,  electric power ,  interaction ,  gene frequency ,  Genome-Wide Association Study ,  *miner (machine) ,  disparity ,  neutral ,  computer application ,  utilization ,  population genetics

Author keywords (5)： GWASs ,  Complex diseases ,  Minor alleles ,  Risk alleles ,  Negative natural selection

JST classification (3)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Data protection  (JD01020V) ,  Structure and chemistry of genes  (EC02020U)

Reference (21)：

• Nucleic Acids Res; The NHGRI GWAS catalog, a curated resource of SNP-trait associations; D Welter, J MacArthur, J Morales, T Burdett, P Hall, H Junkins; 42D; 2014; 1001-1006; 10.1093/nar/gkt1229; citation_id=CR1
• PLoS One; Non-synonymous and synonymous coding SNPs show similar likelihood and effect size of human disease association; R Chen, EV Davydov, M Sirota, AJ Butte; 5; 2010; e13574; 10.1371/journal.pone.0013574; citation_id=CR2
• Nat Rev Genet.; Rare and common variants: twenty arguments; G Gibson; 13; 2012; 135-145; 10.1038/nrg3118; citation_id=CR3
• Nature; Finding the missing heritability of complex diseases; TA Manolio, FS Collins, NJ Cox, DB Goldstein, LA Hindorff, DJ Hunter; 461; 2009; 747-753; 10.1038/nature08494; citation_id=CR4
• PLoS Genet; Allelic spectra of risk SNPs are different for environment/lifestyle dependent versus independent diseases; IP Gorlov, OY Gorlova, C Amos; 11; 2015; e1005371; 10.1371/journal.pgen.1005371; citation_id=CR5

Terms in the title (3)： マイナー ,  対立遺伝子 ,  リスク