YAMAMOTO MASAHIRO

ヤマモトマサヒロ | YAMAMOTO MASAHIRO

Affiliation and department：
Job title：教授
Homepage URL (1)： http://immpara.biken.osaka-u.ac.jp/

Research field (3)： Laboratory animal science , Parasitology , Veterinary medicine

Research keywords (4)：トキソプラズマ , 病原体PLAMP , 寄生虫免疫学 , セルオートノマス免疫系

Research theme for competitive and other funds (24)：

2024 - 2027 新規先天性トキソプラズマ症モデルマウスによるその予防法の開発
2020 - 2024 トキソプラズマ、ネオスポラの潜伏からの活性化を司る分子メカニズムの解明
2020 - 2023 Elucidation of protozoan PLAMP generation mechanism recognized by host cell-autonomous immunity
2020 - 2023 Management of PLAMP research
2020 - 2023 Establishment of PLAMP as a new concept to determine self and nonself for obligatory intracellular pathogens

2019 - 2023 Elucidation of interferon-dependent host defense system against legal infectious disease-causing microbes for domestic animals

2018 - 2022 Pathogenic and genetic analysis of Toxoplasma by Japan, China and South Korea

2019 - 2021 Physiological mechanisms to maintain self and nonself on intracellular membranes, and its pathological failure

2017 - 2019 Elucidation of novel mechanism to discriminate intracellular membranes using Toxoplasma gondii

2017 - 2019 細菌含有膜破壊によるパイロトーシス誘導・制御メカニズムの解明

2017 - 2019 Development of novel serodiagnostic method for the detection of active toxoplasmosis

2015 - 2018 Analysis of Chinese Toxoplasma phylogeny and virulence

2015 - 2018 Analysis of IFN-inducible GTPase-dependent cell-autonomous immunity

2016 - 2017 マトリョーシカ型進化原理の展開

2015 - 2017 CRISPRゲノム編集法によるCaspase-11依存的パイロトーシスの解析

2015 - 2017 Development of the highly efficient Toxoplasma anti-tumor vaccine

2014 - 2016 「寄生胞」を介したトキソプラズマ-宿主間相互支配の“力学”の解明

2013 - 2015 Development of the in vitro maintenance system for undifferentiated stem cells using Toxoplasma ROP16

2012 - 2014 トキソプラズマ原虫「寄生胞」をめぐる寄生体・宿主間の攻防の解明

2011 - 2014 Elucidation of novel innate immune system by analysis of host-parasite interaction

2009 - 2010 原虫による宿主免疫抑制機構の解析

2009 - 2010 Role of a nuclear protein IκBζ in innate immunity

2007 - 2008 Analysis of the mechanisms for innate immune responses to microbes

2007 - 2008 細胞内寄生性原虫の感染防御機構

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Papers (210)：

Masaaki Okamoto, Ayumi Kuratani, Daisuke Okuzaki, Naganori Kamiyama, Takashi Kobayashi, Miwa Sasai, Masahiro Yamamoto. IFN-γ-induced Th1-Treg polarization in inflamed brains limits exacerbation of experimental autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 48. e2401692121
Ayumi Kuratani, Masaaki Okamoto, Kazuki Kishida, Daisuke Okuzaki, Miwa Sasai, Shimon Sakaguchi, Hisashi Arase, Masahiro Yamamoto. Platelet factor 4-induced TH1-Treg polarization suppresses antitumor immunity. Science (New York, N.Y.). 2024. 386. 6724. eadn8608
Yuki Nakayama, Fumiaki Ihara, Daisuke Okuzaki, Yoshifumi Nishikawa, Miwa Sasai, Masahiro Yamamoto. Toxoplasma GRA15 expression on dendritic cells inhibits B cell differentiation and antibody production. Parasitology international. 2024. 102995-102995
Yuta Tachibana, Miwa Sasai, Masahiro Yamamoto. CRISPR screens identify genes essential for in vivo virulence among proteins of hyperLOPIT-unassigned subcellular localization in Toxoplasma. mBio. 2024. 15. 9. e0172824
Masaaki Okamoto, Ayumi Kuratani, Daisuke Okuzaki, Naganori Kamiyama, Takashi Kobayashi, Miwa Sasai, Masahiro Yamamoto. Tff1-expressing Tregs in lung prevent exacerbation of Bleomycin-induced pulmonary fibrosis. Frontiers in immunology. 2024. 15. 1440918-1440918

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MISC (23)：

Miwa Sasai, Masahiro Yamamoto. Gate-16 is required for LC3-independent antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases. CYTOKINE. 2017. 100. 29-29
Mechanisms of Toxoplasma gondii virulence by regulating host immunity. 2015. 64. 6. 533-539
Regulation of Toxoplasmosis by cell-autonomous innate immunity. 2015. 64. 4. 410-415
大嶋淳, 野杁由一郎, 山本雅裕, 林美加子. RabGDIαはインターフェロン-ガンマ誘導性GTPaseによる細胞内寄生性病原体の排除を制御する. 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集. 2015. 142回. 70-70
山本雅裕, 山本雅裕, 大嶋淳, 大嶋淳, 馬知秀, 馬知秀, 神山長慶, 竹田潔, 竹田潔. インターフェロン誘導性遺伝子群GBPの抗トキソプラズマ自然免疫における役割の解明. 日本寄生虫学会大会プログラム・抄録集. 2013. 82nd

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Patents (2)：

TLR LIGAND AND IL-1 RESPONSE-INJURED ANIMAL MODEL
エンドトキシン不応答性モデル動物

Lectures and oral presentations (73)：

The novel VeDTR mouse system reveals roles of immune cells in anti-tumor immunity
(The 2nd Doherty Institute & partners - IFReC Immunology Symposium 2024)
Recognition of PLAMP by cell-autonomous immunity is important for anti-Toxoplasma host defense
(第20回あわじ感染と免疫国際フォーラム 2022)
Role of PLCbeta4 in CD8+ T cell signaling
(2021)
肝臓期マラリア原虫の分化を制御する宿主因子の同定
(第72回日本細菌学会九州支部総会第56回日本ウイルス学会九州支部総会 2019)
Role of CXCR4 in liver stage Plasmodium development
(The 18th Awaji International Forum on Infection and Immunity 2019)

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Education (4)：

2003 - 2006 Osaka University
2001 - 2003 Osaka University Graduate School of Medicine
1999 - 2001 The University of Tokyo Faculty of Science Department of Biological Sciences
1997 - 1999 The University of Tokyo College of Arts and Sciences

Work history (6)：

2018/12 - 現在 Osaka University
2013/07 - 現在 Osaka University Research Institute for Microbial Diseases
2012/01 - 2013/06 Osaka University Research Institute for Microbial Diseases
2010/05 - 2011/12 Osaka University
2007/04 - 2010/04 Osaka University Graduate School of Medicine

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Awards (14)：

2022/10 - 黒住医学研究振興財団第58回小島三郎記念文化賞
2020/09 - 日本微生物学連盟野本賞
2020/05 - 日本寄生虫学会第67回小泉賞
2019/02 - 日本学術振興会第15回日本学術振興会賞
2019/02 - 第15回(平成30年度)日本学術振興会賞

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Association Membership(s) (2)：

日本寄生虫学会 , 日本免疫学会

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