Rchr
J-GLOBAL ID：202001000492801026
Update date: Apr. 09, 2024
Nishiguchi Shigetaka
ニシグチ シゲタカ | Nishiguchi Shigetaka
Affiliation and department：
Job title：
Specially Appointed Assistant Professor (Full-time)
Homepage URL (1)：
https://macromolecularbiotechnology.com/lab-member/
Research field (7)：
Biophysics
, Cell biology
, Molecular biology
, Virology
, Nanobioscience
, Morphology, anatomy
, Evolutionary biology
Research keywords (7)：
遺伝子治療
, ウイルスベクター
, 再構成
, 分子進化
, 細胞間接着
, カドヘリン
, 原子間力顕微鏡
Research theme for competitive and other funds (5)：
- 2024 - 2027 局在化AFM法と温度制御型高速AFMを用いたウイルスゲノムリリース機構の解明
- 2022 - 2025 昆虫系統を特徴づける細胞間接着構造の解明と機能分子デザインへの応用
- 2021 - 2025 Elucidation of the molecular mechanism of spider silk biosynthesis for the realization of various mechanical properties
- 2022 - 2024 カドヘリンのクラスター形成機構および機械刺激による結合構造の制御機構の解明
- 2021 - 2022 動的分子足場を用いたメカノセンサータンパク質の機械特性イメージング
Papers (6)：
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Saeko Yanaka, Atsuji Kodama, Shigetaka Nishiguchi, Rina Hiramine, Jiana Shen, Pornthip Boonsri, Duckyong Sung, Yukiko Isono, Hirokazu Yagi, Yohei Miyanoiri, et al. Identification of potential C1-binding sites in the immunoglobulin CL domains. International Immunology. 2024
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Shigetaka Nishiguchi, Rinshi S. Kasai, Takayuki Uchihashi. Antiparallel dimer structure of CELSR cadherin in solution revealed by high-speed atomic force microscopy. Proceedings of the National Academy of Sciences of the United States of America. 2023
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Shigetaka Nishiguchi, Tadaomi Furuta, Takayuki Uchihashi. Multiple dimeric structures and strand-swap dimerization of E-cadherin in solution visualized by high-speed atomic force microscopy. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 30. e2208067119
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Saeko Yanaka, Shigetaka Nishiguchi, Rina Yogo, Hiroki Watanabe, Jiana Shen, Hirokazu Yagi, Takayuki Uchihashi, Koichi Kato. Quantitative Visualization of the Interaction between Complement Component C1 and Immunoglobulin G: The Effect of CH1 Domain Deletion. International Journal of Molecular Sciences. 2022. 23. 4. 2090-2090
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Shigetaka Nishiguchi, Hiroki Oda. Structural variability and dynamics in the ectodomain of an ancestral-type classical cadherin revealed by AFM imaging. Journal of Cell Science. 2021. 134. 14
ｍore...
MISC (6)：
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西口茂孝, 古田忠臣, 内橋貴之. 高速原子間力顕微鏡で明らかになった細胞間接着分子カドヘリンのダイマー形成過程. 生物物理. 2023
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Shigetaka Nishiguchi, Rinshi S. Kasai, Takayuki Uchihashi. Data for: Antiparallel dimer structure of CELSR cadherin in solution revealed by high-speed atomic force microscopy. Mendeley Data. 2023
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Sanjeevi Sivasankar. Sivasankar S: Faculty Opinions Recommendation of [Nishiguchi S et al., Proc Natl Acad Sci USA 2022 119(30:e2208067119)]. Faculty Opinions. 2022
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Shigetaka Nishiguchi, Tadaomi Furuta, Takayuki Uchihashi. Data for: Multiple dimeric structures and strand-swap dimerization of E-cadherin in solution visualized by high-speed atomic force microscopy. Mendeley Data. 2022
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Shigetaka Nishiguchi. First person - Shigetaka Nishiguchi. Journal of Cell Science. 2021. 134. 14
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Patents (1)：
Lectures and oral presentations (28)：
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Reconstitution and nanoscale visualization of cadherin clusters on supported lipid bilayer in solution (scheduled)
(IUPAB2024 2024)
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高速AFM観察のための分子複合体の再構成手法および高分解能解析手法の開発
(第33回 ExCELLSセミナー ーExCELLS 連携研究 完了報告会ー 2023)
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企業とアカデミアのキャリア紹介
(第6回 ExCELLS若手リトリート 2023)
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マルチモーダル高速AFMを用いた分裂する細菌表層の構造・力学特性・蛍光分子の同時計測
(日本遺伝学会 第95回大会 2023)
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高速AFMと局在化AFM法を用いた接着GPCRの細胞外領域の構造解析
(日本生物物理学会中部支部 令和4年度中部支部講演会 2023)
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Works (1)：
-
超小型遺伝子増幅装置
Shigetaka Nishiguchi, Sho Nakamura, Katsuya Nanba 2013 - 2013
Education (3)：
- 2017 - 2019 Osaka University Graduate School of Science Department of Biological Sciences
- 2010 - 2012 Osaka University Graduate School of Science Department of Biological Sciences
- 2006 - 2010 Konan University Faculty of Science and Engineering Department of Biology
Professional career (1)：
- PhD (Doctor of Science) (Osaka University)
Work history (6)：
Committee career (2)：
- 2019/04 - 現在 Ministry of Education, Culture, Sports, Science and Technology, National Institute of Science and Technology Policy (NISTEP) Expert Investigator
- 2022/08 - 2022/09 AFM BioMed Conference 2022 Conference Secretary
Awards (3)：
- 2022/08 - AFM Biomed Conference 2022 Best Conference Poster Award Visualization of binding processes and cluster formation of cadherin using high-speed atomic force microscopy
- 2022/03 - 令和3年度 生物物理学会中部支部 講演会 最優秀発表賞 動的ダイマーを介した細胞間接着分子の多段階結合過程
- 2021/06 - 第1回 発動分子科学研究会 新学術領域研究 発動分子科学 優秀ポスター賞 高速AFMによる細胞間接着分子の構造ダイナミクスの解析
Association Membership(s) (3)：
Japanese Society for Cell Synthesis Research
, Molecular Robotics Research Group
, The Biophysical Society of Japan
