Rchr
J-GLOBAL ID:202001000803613717
Update date: Apr. 18, 2026
Isobe Shin-Ya
イソベ シンヤ | Isobe Shin-Ya
Affiliation and department:
Osaka University Graduate School of Science, Department of Biological Sciences
About Osaka University Graduate School of Science, Department of Biological Sciences
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Detailed information
Research keywords (1):
DNA damage repair
Research theme for competitive and other funds (7):
2025 - 2028 クロマチンの基盤構造の違いによるDNA損傷応答制御の解明
2024 - 2026 核内ストレス体 (nSB) はレトロトランスポゾン転移抑制に関与するか?
2023 - 2025 ヘテロクロマチン、DNA修復、転写を担う核内非膜性構造体の相互作用の解明
2022 - 2024 DNA損傷応答とクロマチン構造変化の連携の分子レベルでの理解
2023 - 2024 DNA損傷応答とクロマチン構造変化の連携の理解
2022 - 2024 ヘテロクロマチンボディーを制御する非ドメイン型タンパク質AHDC1の解析
2013 - 2015 ヘテロクロマチンにおけるDNA修復メカニズムの解明
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Papers (6):
Takamasa Ito, Masahito Yoshino, Shin-Ya Isobe, Chikashi Obuse. RLF/ZFP292 stabilize CoREST-linked LSD1 engagement at bivalent promoters to safeguard pluripotency. Cell reports. 2026. 45. 4. 117293-117293
Xiaoxuan Zhu, Atabek Bektash, Yuki Hatoyama, Sachiko Muramatsu, Shin-Ya Isobe, Chikashi Obuse, Atsushi Toyoda, Yasukazu Daigaku, Chun-Long Chen, Masato T Kanemaki. Regulated TRESLIN-MTBP loading governs initiation zones and replication timing in human DNA replication. Nature communications. 2025. 16. 1. 10069-10069
Yukiko Kuroda, Aiko Iwata-Otsubo, Kerith-Rae Dias, Suzanna E L Temple, Koji Nagao, Lachlan De Hayr, Ying Zhu, Shin-Ya Isobe, Gohei Nishibuchi, Sarah K Fiordaliso, et al. Dominant-negative variants in CBX1 cause a neurodevelopmental disorder. Genetics in medicine : official journal of the American College of Medical Genetics. 2023. 25. 7. 100861-100861
Shin-Ya Isobe, Shin-Ichiro Hiraga, Koji Nagao, Hiroyuki Sasanuma, Anne D Donaldson, Chikashi Obuse. Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action. Cell reports. 2021. 36. 2. 109383-109383
Shin-Ya Isobe, Koji Nagao, Naohito Nozaki, Hiroshi Kimura, Chikashi Obuse. Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair. CELL REPORTS. 2017. 20. 2. 297-307
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MISC (1):
Koji Nagao, Shin-Ya Isobe, Yoshi-Nobu Ohkubo, Yoko Hayashi-Takanaka, Hiroshi Kimura, Takashi Sado, Chikashi Obuse. Constitution of Higher Order Heterochromatin Structure Based on Epigenetic Code. GENES & GENETIC SYSTEMS. 2016. 91. 6. 318-318
Lectures and oral presentations (28):
Elucidation of the Role of AHDC1 on the Chromocenter, a Non-membranous Chromatin Condensate
(The 3rd Paraspeckle and Condensates Conference 2025)
ヘテロクロマチン領域のDNA損傷応答を制御する新規タンパク質AHDC1の解析
(第28回DNA複製・組換え・修復ワークショップ 2025)
ヘテロクロマチン領域のDNA損傷応答を制御する新規タンパク質AHDC1の解析
(第42回染色体ワークショップ・第23回核ダイナミクス研究会 2025)
ヘテロクロマチンボディーを制御する新規タンパク質AHDC1の解析
(大阪大学先導的学際研究機構 RNAフロンティアサイエンス部門 第1回RNA-FS部門シンポジウム「RNA研究が拓く生命科学」 2023)
Elucidation of novel proteins, SCAI and PP1, involve in regulation of DNA double-strand break repair pathways
(The 65th Annual Meeting of the Japanese Radiation Research Society 2022)
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