Rchr
J-GLOBAL ID：202001002287608070
Update date: Sep. 19, 2024
Tsukimura Takahiro
ツキムラ タカヒロ | Tsukimura Takahiro
Affiliation and department：
Job title：
講師
Research field (2)：
Pathobiochemistry
, Genetics
Research keywords (4)：
ファブリー病
, 生化学
, 遺伝学
, リソソーム病
Research theme for competitive and other funds (5)：
- 2022 - 2023 ファブリー病診断のための尿中グロボトリアオシルセラミドの簡便な検出法の開発
- 2018 - 2021 ファブリー病のミスセンス変異と機能的多型の分子病態の解析と診断への応用
- 2015 - 2018 Development of new enzyme replacement therapy for Fabry disease with a high-functioning enzyme expected to escape from harmful immune reaction
- 2013 - 2016 Effect of co-administration with analogs on enzyme preparation
- 2009 - 2012 Thermodynamic and structural study on the interaction of an enzyme and a substrate analogue for development of new therapy for lysosomal diseases
Papers (48)：
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Takahiro Tsukimura, Tomoko Shiga, Tadayasu Togawa, Hitoshi Sakuraba. Comparative study on incorporation of three recombinant human α-galactosidase A drugs (agalsidases) into cultured fibroblasts and organs/tissues of Fabry mice. Molecular Genetics and Metabolism Reports. 2024. 40. 101118-101118
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Takahiro Tsukimura, Koki Saito, Tomoko Shiga, Yasuhiro Ogawa, Hitoshi Sakuraba, Tadayasu Togawa. Does administration of hydroxychloroquine/amiodarone affect the efficacy of enzyme replacement therapy for Fabry mice?. Molecular Genetics and Metabolism Reports. 2024. 39. 101079-101079
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Tomoko Shiga, Takahiro Tsukimura, Takao Kubota, Tadayasu Togawa, Hitoshi Sakuraba. Profiles of Globotriaosylsphingosine Analogs and Globotriaosylceramide Isoforms Accumulated in Body Fluids from Various Phenotypic Fabry Patients. Internal Medicine. 2024. 63. 11. 1531-1537
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Hisato Shima, Takahiro Tsukimura, Tomoko Shiga, Tadayasu Togawa, Hitoshi Sakuraba, Toshio Doi, Yuka Ikeda, Takuya Okamoto, Yukari Yoshikawa, Takehiko Kimura, et al. Effects of switching from agalsidase-α to agalsidase-β on biomarkers, renal and cardiac parameters, and disease severity in fabry disease forming neutralizing antidrug antibodies: a case report. CEN Case Reports. 2023
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Yaroslav Winter, Max Hilz, Felix Beuschlein, Takahiro Tsukimura, Erich Seifritz, Malte Lenders, Eva Brand, Julia B. Hennermann, Albina Nowak. Screening for health-related quality of life and its determinants in Fabry disease: A cross-sectional multicenter study. Molecular Genetics and Metabolism. 2023. 140. 3. 107692-107692
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MISC (12)：
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Takahiro Tsukimura. Biomarker for lysosomal storage disease. Japanese Journal of Clinical Medicine. 2024. 82. 5. 675-680
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Takahiro Tsukimura. Genetic testing and biochemical analysis of lysosomal storage disease. Japanese Jornal of Clinical Medicine. 2024. 82. 5. 650-655
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Takahiro Tsukimura, Tadayasu Togawa, Tomotaro Wakamura, Hiroshi Kato, Hitoshi Sakuraba. From diagnosis to follow-up of Fabry patients receiving enzyme replacement therapy in Japan. MOLECULAR GENETICS AND METABOLISM. 2017. 120. 1-2. S132-S132
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Takahiro Tsukimura, Futoshi Shibasaki, Masashi Shigenaga, Tadayasu Togawa, Hitoshi Sakuraba. Anti-alpha-galactosidase A antibodies and serum-mediated inhibition in Fabry disease. MOLECULAR GENETICS AND METABOLISM. 2016. 117. 2. S115-S115
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Tadayasu Togawa, Takashi Kodama, Takahiro Tsukimura, Ikuo Kawashima, Toshie Tanaka, Tomoko Shiga, Atsuko Sato, Hitoshi Sakuraba. Measurement of glycosphingolipids by means of tandem mass spectrometry and evaluation of them as a biomarker of Fabry disease. MOLECULAR GENETICS AND METABOLISM. 2016. 117. 2. S112-S113
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Patents (4)：
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リン酸化糖鎖を含有する組換えヒトサポシンBタンパク質及びその用途
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ファブリー病の発症危険度を判定する方法及びマーカー
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ファブリー病治療用医薬の組合せ物及びその利用
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ファブリー病治療用の細胞医薬
Books (2)：
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ライソゾーム病 : 最新の病態,診断,治療の進歩
診断と治療社 2023 ISBN:9784787825971
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ファブリー病UpDate
診断と治療社 2021 ISBN:9784787825308
Lectures and oral presentations (2)：
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血清中抗α-ガラクトシダーゼA抗体の測定
(第10回ファブリー病シンポジウム 2016)
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High risk screening for Fabry disease in Japan
(The 3rd Asian Congress for Lysosomal Storage Disease Screening 2015)
Work history (3)：
- 2020/04 - 現在 Meiji Pharmaceutical University
- 2012/04 - 2020/03 Meiji Pharmaceutical University
- 2018/09 - 2019/08 Icahn School of Medicine at Mount Sinai
Awards (2)：
- 2011/11 - 第53回日本先天代謝異常学会 若手優秀演題賞
- 2010/10 - 第52回日本先天代謝異常学会 若手優秀演題賞
Association Membership(s) (3)：
日本薬学会
, 日本生化学会
, 日本先天代謝異常学会
