Rchr
J-GLOBAL ID：202001002423676980
Update date: Aug. 07, 2024
YABE SHIGEHARU
ヤベ シゲハル | YABE SHIGEHARU
Affiliation and department：
Job title：
上級研究員
Research theme for competitive and other funds (4)：
- 2024 - 2027 ヒトiPS細胞由来膵α細胞によるアセチルコリン分泌及び膵β細胞相互作用解析
- 2020 - 2023 Differentiation method of human pluripotent stem cells-derived pancratic alpha cells
- 2016 - 2018 Establishment of Immortal Dermal papilla cells and Hair follicle regeneration technology
- 2014 - 2016 Pathologic analysis of MODY using pancreatic beta cells derived from MODY-iPS cells.
Papers (27)：
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Luyao Wang, Yuta Koui, Kazuko Kanegae, Taketomo Kido, Miwa Tamura-Nakano, Shigeharu Yabe, Kenpei Tai, Yoshiko Nakajima, Hiroyuki Kusuhara, Yasuyuki Sakai, et al. Establishment of human induced pluripotent stem cell-derived hepatobiliary organoid with bile duct for pharmaceutical research use. Biomaterials. 2024. 310. 122621-122621
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Kenta Nakano, Motohito Goto, Satsuki Fukuda, Rieko Yanobu-Takanashi, Shigeharu G Yabe, Yukiko Shimizu, Tetsushi Sakuma, Takashi Yamamoto, Masayuki Shimoda, Hitoshi Okochi, et al. A Novel Immunodeficient Hyperglycemic Mouse Carrying the Ins1 Akita Mutation for Xenogeneic Islet Cell Transplantation. Transplantation. 2024
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Junko Nishida, Takahiro Tsuno, Shigeharu G. Yabe, Tatsuya Kin, Satsuki Fukuda, Fujie Takeda, Jun Shirakawa, Hitoshi Okochi. Encapsulated human islets in alginate fiber maintain long-term functionality. Endocrine Journal. 2024. 71. 3. 253-264
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Shigeharu G Yabe, Satsuki Fukuda, Junko Nishida, Fujie Takeda, Hitoshi Okochi. The functional maturity of grafted human pluripotent stem cell derived-islets (hSC-Islets) evaluated by the glycemic set point during blood glucose normalizing process in diabetic mice. Heliyon. 2023. 9. 9. e19972
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Nobuyo Higashi-Kuwata, Shigeharu G Yabe, Satsuki Fukuda, Junko Nishida, Miwa Tamura-Nakano, Shin-Ichiro Hattori, Hitoshi Okochi, Hiroaki Mitsuya. Generation of Angiotensin-Converting Enzyme 2/Transmembrane Protease Serine 2-Double-Positive Human Induced Pluripotent Stem Cell-Derived Spheroids for Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Drug Evaluation. Microbiology spectrum. 2022. e0349022
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MISC (9)：
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大河内 仁志, 矢部 茂治, 宮島 篤. 【iPS細胞のDDSへの応用】ヒトiPS細胞由来の膵島細胞(spheroid)を用いたインスリン補充療法. Drug Delivery System. 2020. 35. 4. 293-300
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矢部 茂治. 糖尿病 基礎研究から臨床応用へ向けて 再生医学 iPS細胞からの膵ベータ細胞の分化誘導. 日本獣医学会学術集会講演要旨集. 2018. 161回. 257-257
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OKOCHI Hitoshi, YABE Shigeharu, SHIMODA Masayuki. Pancreas and pancreatic islet. Japanese Journal of Transplantation. 2017. 52. 4. 325-331
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霜田 雅之, 矢部 茂治, 篠原 孝也, 元 文姫, 福田 沙月, 渡邊 亜美, 渡邊 貴一, 篠原 満利恵, 井上 貴史, 伊吹 将人, et al. 再生医療と移植医療の新展開 iPS細胞を用いた次世代型膵島移植療法の開発. 糖尿病. 2016. 59. Suppl.1. S-106
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霜田雅之, 矢部茂治, 篠原孝也, 元文姫, 福田沙月, 渡邊亜美, 渡邊貴一, 篠原満利恵, 井上貴史, 伊吹将人, et al. iPS細胞を用いた次世代型膵島移植療法の開発. 糖尿病(Web). 2016. 59. Suppl
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Patents (4)：
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膵臓α細胞への分化誘導方法
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PRODUCTION METHOD FOR PANCREATIC β CELLS
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PRODUCTION METHOD FOR PRIMITIVE GUT TUBE CELLS
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ENDODERMAL CELL MASS, AND METHOD FOR PRODUCING ANY ONE OF THREE PRIMARY GERM LAYER CELL MASS FROM PLURIPOTENT CELLS
Books (2)：
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膵臓と膵島
一般社団法人 日本移植学会 2017
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膵島の再生医療ー膵β細胞の発生と再生をめぐる新展開ー
診断と治療社 2015
Lectures and oral presentations (7)：
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MODY-iPS-β細胞を用いた変異mRNAと変異タンパク質の発現解析
(第19回日本再生医療学会総会 2020)
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バイオリアクターを用いた浮遊培養系によるヒトiPS細胞由来機能的膵β細胞の分化誘導
(第18回日本再生医療学会総会 2019)
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再生医学-iPS細胞からの膵ベータ細胞の分化誘導
(日本実験動物医学会シンポジウム 2018)
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ヒトiPS細胞のDefinitive endoderm(DE)分化過程における接着培養と浮遊培養の比較検討
(第17回日本再生医療学会総会 2018)
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A novel beta cell replacement therapy with human iPS cells.
(Kyoto Diabetes Mini-Symposium Beta-Cell Replacement Strategies. 2017)
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Awards (2)：
- 2018 - National Center for Global Health and Medicine NCGM Director's Award
- 2017 - National Center for Global Health and Medicine NCGM Director's Award
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