Rchr
J-GLOBAL ID：202001002423676980
Update date: Jul. 17, 2024
YABE SHIGEHARU
ヤベ シゲハル | YABE SHIGEHARU
Affiliation and department：
Job title：
上級研究員
Research theme for competitive and other funds (4)：
- 2024 - 2027 ヒトiPS細胞由来膵α細胞によるアセチルコリン分泌及び膵β細胞相互作用解析
- 2020 - 2023 Differentiation method of human pluripotent stem cells-derived pancratic alpha cells
- 2016 - 2018 Establishment of Immortal Dermal papilla cells and Hair follicle regeneration technology
- 2014 - 2016 Pathologic analysis of MODY using pancreatic beta cells derived from MODY-iPS cells.
Papers (24)：
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Shigeharu G Yabe, Satsuki Fukuda, Junko Nishida, Fujie Takeda, Hitoshi Okochi. The functional maturity of grafted human pluripotent stem cell derived-islets (hSC-Islets) evaluated by the glycemic set point during blood glucose normalizing process in diabetic mice. Heliyon. 2023. 9. 9. e19972
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Nobuyo Higashi-Kuwata, Shigeharu G Yabe, Satsuki Fukuda, Junko Nishida, Miwa Tamura-Nakano, Shin-Ichiro Hattori, Hitoshi Okochi, Hiroaki Mitsuya. Generation of Angiotensin-Converting Enzyme 2/Transmembrane Protease Serine 2-Double-Positive Human Induced Pluripotent Stem Cell-Derived Spheroids for Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Drug Evaluation. Microbiology spectrum. 2022. e0349022
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Mayumi Ikeda, Shigeharu Yabe, Masahiro Kiso, Naoko Ishiguro, Yuichiro Tsunemi, Hitoshi Okochi. TERT/BMI1-transgenic human dermal papilla cells enhance murine hair follicle formation in vivo. Journal of dermatological science. 2022
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Fumisato Ozawa, Shogo Nagata, Haruka Oda, Shigeharu G Yabe, Hitoshi Okochi, Shoji Takeuchi. Lotus-root-shaped cell-encapsulated construct as a retrieval graft for long-term transplantation of human iPSC-derived β-cells. iScience. 2021. 24. 4. 102309-102309
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Shigeharu G Yabe, Satsuki Fukuda, Junko Nishida, Fujie Takeda, Kiyoko Nashiro, Hitoshi Okochi. Efficient induction of pancreatic alpha cells from human induced pluripotent stem cells by controlling the timing for BMP antagonism and activation of retinoic acid signaling. PloS one. 2021. 16. 1. e0245204
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MISC (9)：
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大河内 仁志, 矢部 茂治, 宮島 篤. 【iPS細胞のDDSへの応用】ヒトiPS細胞由来の膵島細胞(spheroid)を用いたインスリン補充療法. Drug Delivery System. 2020. 35. 4. 293-300
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矢部 茂治. 糖尿病 基礎研究から臨床応用へ向けて 再生医学 iPS細胞からの膵ベータ細胞の分化誘導. 日本獣医学会学術集会講演要旨集. 2018. 161回. 257-257
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OKOCHI Hitoshi, YABE Shigeharu, SHIMODA Masayuki. Pancreas and pancreatic islet. Japanese Journal of Transplantation. 2017. 52. 4. 325-331
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霜田 雅之, 矢部 茂治, 篠原 孝也, 元 文姫, 福田 沙月, 渡邊 亜美, 渡邊 貴一, 篠原 満利恵, 井上 貴史, 伊吹 将人, et al. 再生医療と移植医療の新展開 iPS細胞を用いた次世代型膵島移植療法の開発. 糖尿病. 2016. 59. Suppl.1. S-106
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霜田雅之, 矢部茂治, 篠原孝也, 元文姫, 福田沙月, 渡邊亜美, 渡邊貴一, 篠原満利恵, 井上貴史, 伊吹将人, et al. iPS細胞を用いた次世代型膵島移植療法の開発. 糖尿病(Web). 2016. 59. Suppl
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Patents (4)：
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膵臓α細胞への分化誘導方法
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PRODUCTION METHOD FOR PANCREATIC β CELLS
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PRODUCTION METHOD FOR PRIMITIVE GUT TUBE CELLS
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ENDODERMAL CELL MASS, AND METHOD FOR PRODUCING ANY ONE OF THREE PRIMARY GERM LAYER CELL MASS FROM PLURIPOTENT CELLS
Books (2)：
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膵臓と膵島
一般社団法人 日本移植学会 2017
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膵島の再生医療ー膵β細胞の発生と再生をめぐる新展開ー
診断と治療社 2015
Lectures and oral presentations (7)：
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MODY-iPS-β細胞を用いた変異mRNAと変異タンパク質の発現解析
(第19回日本再生医療学会総会 2020)
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バイオリアクターを用いた浮遊培養系によるヒトiPS細胞由来機能的膵β細胞の分化誘導
(第18回日本再生医療学会総会 2019)
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再生医学-iPS細胞からの膵ベータ細胞の分化誘導
(日本実験動物医学会シンポジウム 2018)
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ヒトiPS細胞のDefinitive endoderm(DE)分化過程における接着培養と浮遊培養の比較検討
(第17回日本再生医療学会総会 2018)
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A novel beta cell replacement therapy with human iPS cells.
(Kyoto Diabetes Mini-Symposium Beta-Cell Replacement Strategies. 2017)
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Awards (2)：
- 2018 - National Center for Global Health and Medicine NCGM Director's Award
- 2017 - National Center for Global Health and Medicine NCGM Director's Award
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