Rchr
J-GLOBAL ID:202001002423676980   Update date: Jun. 04, 2021

YABE SHIGEHARU

ヤベ シゲハル | YABE SHIGEHARU
Affiliation and department:
Job title: 上級研究員
Research theme for competitive and other funds  (3):
  • 2020 - 2023 グルカゴン分泌機構解明のためのヒトiPS細胞由来膵α細胞の分化誘導系の構築
  • 2016 - 2018 Establishment of Immortal Dermal papilla cells and Hair follicle regeneration technology
  • 2014 - 2016 Pathologic analysis of MODY using pancreatic beta cells derived from MODY-iPS cells.
Papers (20):
  • Fumisato Ozawa, Shogo Nagata, Haruka Oda, Shigeharu G Yabe, Hitoshi Okochi, Shoji Takeuchi. Lotus-root-shaped cell-encapsulated construct as a retrieval graft for long-term transplantation of human iPSC-derived β-cells. iScience. 2021. 24. 4. 102309-102309
  • Shigeharu G Yabe, Satsuki Fukuda, Junko Nishida, Fujie Takeda, Kiyoko Nashiro, Hitoshi Okochi. Efficient induction of pancreatic alpha cells from human induced pluripotent stem cells by controlling the timing for BMP antagonism and activation of retinoic acid signaling. PloS one. 2021. 16. 1. e0245204
  • Marie Shinohara, Hyunjin Choi, Masato Ibuki, Shigeharu G Yabe, Hitoshi Okochi, Atsushi Miyajima, Yasuyuki Sakai. Endodermal differentiation of human induced pluripotent stem cells using simple dialysis culture system in suspension culture. Regenerative therapy. 2019. 12. 14-19
  • Satsuki Fukuda, Shigeharu G Yabe, Junko Nishida, Fujie Takeda, Kiyoko Nashiro, Hitoshi Okochi. The intraperitoneal space is more favorable than the subcutaneous one for transplanting alginate fiber containing iPS-derived islet-like cells. Regenerative therapy. 2019. 11. 65-72
  • Shigeharu G Yabe, Satsuki Fukuda, Junko Nishida, Fujie Takeda, Kiyoko Nashiro, Hitoshi Okochi. Induction of functional islet-like cells from human iPS cells by suspension culture. Regenerative therapy. 2019. 10. 69-76
more...
MISC (6):
  • 矢部 茂治. 糖尿病 基礎研究から臨床応用へ向けて 再生医学 iPS細胞からの膵ベータ細胞の分化誘導. 日本獣医学会学術集会講演要旨集. 2018. 161回. 257-257
  • OKOCHI Hitoshi, YABE Shigeharu, SHIMODA Masayuki. Pancreas and pancreatic islet. Japanese Journal of Transplantation. 2017. 52. 4. 325-331
  • 霜田 雅之, 矢部 茂治, 篠原 孝也, 元 文姫, 福田 沙月, 渡邊 亜美, 渡邊 貴一, 篠原 満利恵, 井上 貴史, 伊吹 将人, et al. 再生医療と移植医療の新展開 iPS細胞を用いた次世代型膵島移植療法の開発. 糖尿病. 2016. 59. Suppl.1. S-106
  • 田積 俊介, 横山 純, 矢部 茂治, 内山 英穂. アフリカツメガエルにおいてpMesogenin1/2はXtbx6の標的遺伝子(pMesogenin1/2 are target genes of Xtbx6 in Xenopus laevis). 日本発生生物学会・日本細胞生物学会合同大会要旨集. 2007. 40回・59回. 110-110
  • H Uchiyama, T Kobayashi, A Yamashita, S Ohno, S Yabe. Cloning and characterization of the T-box gene Tbx6 in Xenopus laevis. (vol 43, pg 657, 2001). DEVELOPMENT GROWTH & DIFFERENTIATION. 2002. 44. 1. 95-96
more...
Patents (4):
  • 膵臓α細胞への分化誘導方法
  • PRODUCTION METHOD FOR PANCREATIC β CELLS
  • PRODUCTION METHOD FOR PRIMITIVE GUT TUBE CELLS
  • ENDODERMAL CELL MASS, AND METHOD FOR PRODUCING ANY ONE OF THREE PRIMARY GERM LAYER CELL MASS FROM PLURIPOTENT CELLS
Books (2):
  • 膵臓と膵島
    一般社団法人 日本移植学会 2017
  • 膵島の再生医療ー膵β細胞の発生と再生をめぐる新展開ー
    診断と治療社 2015
Lectures and oral presentations  (7):
  • MODY-iPS-β細胞を用いた変異mRNAと変異タンパク質の発現解析
    (第19回日本再生医療学会総会 2020)
  • バイオリアクターを用いた浮遊培養系によるヒトiPS細胞由来機能的膵β細胞の分化誘導
    (第18回日本再生医療学会総会 2019)
  • 再生医学-iPS細胞からの膵ベータ細胞の分化誘導
    (日本実験動物医学会シンポジウム 2018)
  • ヒトiPS細胞のDefinitive endoderm(DE)分化過程における接着培養と浮遊培養の比較検討
    (第17回日本再生医療学会総会 2018)
  • A novel beta cell replacement therapy with human iPS cells.
    (Kyoto Diabetes Mini-Symposium Beta-Cell Replacement Strategies. 2017)
more...
Awards (2):
  • 2018 - National Center for Global Health and Medicine NCGM Director's Award
  • 2017 - National Center for Global Health and Medicine NCGM Director's Award
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