SEKIBA KAZUMA

セキバカズマ | SEKIBA KAZUMA

Affiliation and department：
Job title：特任臨床医

Research field (3)： Pathobiochemistry , Virology , Gastroenterology

Research theme for competitive and other funds (1)：

2019 - 2021 遺伝子編集技術を駆使したHBV感染維持機構に関わる因子の網羅的同定と介入法の開発

Papers (29)：

Takuma Iwata, Takahiro Kishikawa, Takahiro Seimiya, Genso Notoya, Tatsunori Suzuki, Chikako Shibata, Yu Miyakawa, Nariaki Odawara, Kazuyoshi Funato, Eri Tanaka, et al. Satellite double-stranded RNA induces mesenchymal transition in pancreatic cancer by regulating alternative splicing. The Journal of biological chemistry. 2024. 300. 3. 105742-105742
Kazuyoshi Funato, Nozomi Miyake, Kazuma Sekiba, Yu Miyakawa, Takahiro Seimiya, Chikako Shibata, Takahiro Kishikawa, Motoyuki Otsuka. Cabozantinib inhibits HBV-RNA transcription by decreasing STAT3 binding to the enhancer region of cccDNA. Hepatology communications. 2023. 7. 11
Takahiro Seimiya, Tatsunori Suzuki, Takuma Iwata, Takahiro Kishikawa, Kazuma Sekiba, Chikako Shibata, Kazunaga Ishigaki, Hiroaki Fujiwara, Hiroki Oyama, Sachiko Kanai, et al. Combination of serum human satellite RNA and miR-21-5p levels as a biomarker for pancreatic cancer. iScience. 2023. 26. 2. 106021-106021
Kazuyoshi Funato, Motoyuki Otsuka, Kazuma Sekiba, Yu Miyakawa, Takahiro Seimiya, Chikako Shibata, Takahiro Kishikawa, Mitsuhiro Fujishiro. Hepatitis B virus-associated hepatocellular carcinoma with Smc5/6 complex deficiency is susceptible to PARP inhibitors. Biochemical and biophysical research communications. 2022. 607. 89-95
Kazuma Sekiba, Motoyuki Otsuka, Kazuyoshi Funato, Yu Miyakawa, Eri Tanaka, Takahiro Seimiya, Mari Yamagami, Takeya Tsutsumi, Kazuya Okushin, Kei Miyakawa, et al. HBx-induced degradation of Smc5/6 complex impairs homologous recombination-mediated repair of damaged DNA. Journal of hepatology. 2021. 76. 1. 53-62

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MISC (43)：

神崎洋彰, 千葉哲博, 興梠慧輔, 日下部裕子, 小林和史, 叶川直哉, 清野宗一郎, 中村昌人, 近藤孝行, 齊藤朋子, et al. RNA結合蛋白ELAVL1のB型肝炎ウイルス複製と肝細胞癌増殖への関わり. 肝臓. 2022. 63. Suppl.1. A335-A335
豊島治, 西澤俊宏, 小池和彦, 崎谷康佑, 吉田俊太郎, 高橋由至, 金沢孝満, 新野徹, 片岡陽佑, 深川一史, et al. 高リスク腺腫の検出と結腸内視鏡サーベイランスの施行間隔傾向スコアマッチング研究(Detection of high-risk adenomas and the colonoscopy surveillance interval: a propensity score-matching study). Gastroenterological Endoscopy. 2020. 62. Suppl.1. 1263-1263
關場一磨, 大塚基之, 小池和彦. B型肝炎根治を目指した創薬研究宿主蛋白Smc5/6の発現回復によるHBV関連肝発癌制御の可能性. 日本消化器病学会雑誌. 2020. 117. 臨増総会. A93-A93
大塚基之, 關場一磨, 船戸和義, 小池和彦. 【B型肝炎Trends & Topics】新規抗B型肝炎ウイルス薬の開発の現状と展望. 臨床消化器内科. 2020. 35. 2. 205-210
大塚基之, 關場一磨, 船戸和義, 小池和彦. 【B型肝炎Trends & Topics】新規抗B型肝炎ウイルス薬の開発の現状と展望. 臨床消化器内科. 2020. 35. 2. 205-210

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Education (1)：

2016 - 2020 The University of Tokyo Graduate School of Medicine Department of Gastroenterology

Work history (8)：

2021/07 - 現在スタンフォード大学医学部微生物学・免疫学教室 / 病理学教室博士研究員
2021/07 - 現在 Japan Society for the Promotion of Science
2016/04 - 現在東京大学医学部附属病院消化器内科
2020/04 - 2021/03 日本学術振興会特別研究員(PD)
2019/04 - 2020/03 日本学術振興会特別研究員(DC2)

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Awards (4)：

2019/11 - 日本肝臓学会冠Award(第4回 Gilead Sciences Award)
2019/11 - American Association for the Study of Liver Diseases (AASLD) Early Career Investigator Award in Basic Science
2019/05 - Digestive Disease Week (DDW) Basic Science Travel Award
2018/11 - American Association for the Study of Liver Diseases (AASLD) Early Career Investigator Award in Basic Science

Association Membership(s) (6)：

日本がん治療認定医機構 , 日本生化学会 , 日本消化器内視鏡学会 , 日本消化器病学会 , 日本肝臓学会 , 日本内科学会

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