Research theme for competitive and other funds (3):
2020 - 2024 ZTTK症候群の知的障害発症機構解明を目指した核内蛋白質SONの機能解析
2017 - 2023 自閉症原因遺伝子NLGN4Xの発現変化に起因する分子病態の解析
2017 - 2020 The elucidation of the cellular pathological mechanism of ZTTK syndrome, an intellectual disability, which is caused by SON haploinsufficiency
Papers (22):
Tohru Matsuki, Hidenori Tabata, Masashi Ueda, Hideaki Ito, Koh-ichi Nagata, Yumi Tsuneura, Shima Eda, Kenji Kasai, Atsuo Nakayama. The MCPH7 Gene Product STIL Is Essential for Dendritic Spine Formation. Cells. 2025
Akie Toya, Masahide Fukada, Eiko Aoki, Tohru Matsuki, Masashi Ueda, Shima Eda, Yoshio Hashizume, Akio Iio, Shigeo Masaki, Atsuo Nakayama. The distribution of neuroligin4, an autism-related postsynaptic molecule, in the human brain. Molecular brain. 2023. 16. 1. 20-20
Kiyomi Nakagawa, Saiful Islam, Masashi Ueda, Toshiyuki Nakagawa. Endoplasmic reticulum stress contributes to the decline in doublecortin expression in the immature neurons of mice with long-term obesity. Scientific reports. 2022. 12. 1. 1022-1022
Tohru Matsuki, Akio Iio, Masashi Ueda, Yumi Tsuneura, Brian W Howell, Atsuo Nakayama. STK25 and MST3 have overlapping roles to regulate Rho GTPases during cortical development. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2021. 41. 43. 8887-8903
Masashi Ueda, Tohru Matsuki, Masahide Fukada, Shima Eda, Akie Toya, Akio Iio, Hidenori Tabata, Atsuo Nakayama. Knockdown of Son, a mouse homologue of the ZTTK syndrome gene, causes neuronal migration defects and dendritic spine abnormalities. Molecular brain. 2020. 13. 1. 80-80
SON haploinsufficiency, a cause of human intellectual disabilities, affects the neuronal migrations and dendritic spine formations in the developing mouse brain
(Society for Neuroscience (49th Annual Meeting))
SON haploinsufficiency, which is causing an intellectual disability, dysregulates neuronal migration in developing mouse brain
(The 11th NAGOYA Global Retreat 2019)
Insertion of polyglutamine to the endoplasmic reticulum membrane with the morphological disruption initiates the cell death through Bax
(The 9th NAGOYA Global Retreat 2017)
Polyglutamine expansion affects morphology of the endoplasmic reticulum-mitochondria contact sites, initiating cell death
(Society for Neuroscience (43nd Annual Meeting))
Disruption of the endoplasmic reticulum by polyglutamine expansion induces Apaf-1-dependent, activation of caspase-7
(Society for Neuroscience (39th Annual Meeting))
Education (3):
2007 - 2013 Gifu University Graduate School of Medicine
2005 - 2007 Gifu University Graduate School of Medicine
2001 - 2005 Gifu Pharmaceutical University Faculty of Pharmaceutical Science Department of Manufacturing Pharmacy
Professional career (1):
Regeneration and Advanced Medical Sciences (Gifu University)
Work history (4):
2022/06 - 現在 Aichi Medical University School of Medicine
2020/05 - 2022/05 National Center of Neurology and Psychiatry