Kagoya Yuki

カゴヤユウキ | Kagoya Yuki

Affiliation and department：
Job title： Professor

Research field (1)： Immunology

Research theme for competitive and other funds (6)：

2023 - 2026 Development of CAR-NK cell therapy with durable response through genetic manipulation
2022 - 2025 The determination of T-cell fate by different tumor antigens and prevention of post-operative recurrence of lung cancer
2021 - 2023 Development of a combinatorial approach of antibody therapeutics and adoptive immunotherapy for cancer
2020 - 2023 Generation of long-surviving antitumor T cells by genetic modification for optimal adoptive immunotherapy
2019 - 2021 Development of a chimeric synthetic receptor to suppress T cell exhaustion for use in adoptive cancer immunotherapy

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Papers (48)：

Toshiaki Yoshikawa, Yusuke Ito, Zhiwen Wu, Hitomi Kasuya, Takahiro Nakashima, Sachiko Okamoto, Yasunori Amaishi, Haosong Zhang, Yang Li, Tetsuya Matsukawa, et al. Development of a chimeric cytokine receptor that captures IL-6 and enhances the antitumor response of CAR-T cells. Cell Reports Medicine. 2024. 5. 5. 101526-101526
Nakashima T, Kagoya Y. Current progress of CAR-T-cell therapy for patients with multiple myeloma. Int J Hematol. 2024
Hitomi Kasuya, Haosong Zhang, Yusuke Ito, Toshiaki Yoshikawa, Takahiro Nakashima, Yang Li, Tetsuya Matsukawa, Satoshi Inoue, Yuki Kagoya. High CD62L expression predicts the generation of chimeric antigen receptor T cells with potent effector functions. International Immunology. 2024. 36. 7. 353-364
Yuki Kagoya. Cytokine signaling in chimeric antigen receptor T-cell therapy. International Immunology. 2024. 36. 2. 49-56
Yusuke Ito, Satoshi Inoue, Takahiro Nakashima, Haosong Zhang, Yang Li, Hitomi Kasuya, Tetsuya Matsukawa, Zhiwen Wu, Toshiaki Yoshikawa, Mirei Kataoka, et al. Epigenetic profiles guide improved CRISPR/Cas9-mediated gene knockout in human T cells. Nucleic Acids Research. 2024. 52. 1. 141-153

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MISC (9)：

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Lectures and oral presentations (48)：

CAR-T細胞の前臨床評価におけるヒト化マウスの活用
(2024)
Regulation of cytokine signaling for improved adoptive immunotherapy
(The 42nd Sapporo International Cancer Symposium 2024)
Reinforcing CAR-T cell function through metabolic regulation
(2024)
Adoptive immunotherapy for autoimmune diseases
(2024)
Understanding the mechanisms of resistance to CAR-T cell therapy at the molecular level
(The 1st International Symposium on Cancer Immunology and Immunotherapy 2024)

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Education (2)：

Professional career (1)：

Work history (8)：

2023/01 - 現在 Keio University School of Medicine Division of Tumor Immunology, Institute for Advanced Medical Research Professor
2020/04 - 2022/12 Nagoya University Graduate School of Medicine Division of Cellular Oncology, Department of Cancer Diagnostics and Therapeutics Adjunct Professor
2019/10 - 2022/12 Aichi Cancer Center, Research Institute Division of Immune Response Chief
2018/06 - 2019/09 The University of Tokyo Faculty of Medicine University Hospital Assistant Professor
2014/06 - 2018/05 Princess Margaret Cancer Centre Tumor Immunotherapy Program Research Fellow

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