Kikuchi Osamu

Research field (1)： Tumor diagnostics and therapeutics

Research theme for competitive and other funds (1)：

2020 - 2023 KRASの超生理的活性化を標的としたKRAS増幅胃癌フェロトーシス誘導療法の開発

Papers (34)：

Trang H. Nguyen Vu, Osamu Kikuchi, Shinya Ohashi, Tomoki Saito, Tomomi Ida, Yukie Nakai, Yang Cao, Yoshihiro Yamamoto, Yuki Kondo, Yosuke Mitani, et al. Combination therapy with WEE1 inhibition and trifluridine/tipiracil against esophageal squamous cell carcinoma. Cancer Science. 2023. 114. 12. 4664-4676
Tianxia Li, Osamu Kikuchi, Jin Zhou, Yichen Wang, Babita Pokharel, Klavdija Bastl, Prafulla Gokhale, Aine Knott, Yanxi Zhang, John G. Doench, et al. Developing SHP2-based combination therapy for KRAS-amplified cancer. JCI Insight. 2023
Norihide Jo, Yu Hidaka, Osamu Kikuchi, Masaru Fukahori, Takeshi Sawada, Masahiko Aoki, Masaki Yamamoto, Miki Nagao, Satoshi Morita, Takako E. Nakajima, et al. Impaired CD4+ T cell response in older adults is associated with reduced immunogenicity and reactogenicity of mRNA COVID-19 vaccination. Nature Aging. 2023
Tomoyuki Abe, Yoshihito Horisawa, Osamu Kikuchi, Hitomi Ozawa-Umeta, Atsuhiro Kishimoto, Yasuhiro Katsuura, Atsushi Imaizumi, Tadashi Hashimoto, Kotaro Shirakawa, Akifumi Takaori-Kondo, et al. Pharmacologic characterization of TBP1901, a prodrug form of aglycone curcumin, and CRISPR-Cas9 screen for therapeutic targets of aglycone curcumin. European journal of pharmacology. 2022. 935. 175321-175321
Yosuke Mitani, Shinya Ohashi, Osamu Kikuchi, Yukie Nakai, Tomomi Ida, Ayaka Mizumoto, Yoshihiro Yamamoto, Tomoki Saito, Shigeki Kataoka, Junichi Matsubara, et al. HER2 G776S mutation promotes oncogenic potential in colorectal cancer cells when accompanied by loss of APC function. Scientific reports. 2022. 12. 1. 9213-9213

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MISC (15)：

Masahiro Yoshioka, Shinya Ohashi, Tomomi Ida, Yukie Nakai, Osamu Kikuchi, Yusuke Amanuma, Jun'ichi Matsubara, Atsushi Yamada, Shin'ichi Miyamoto, Manabu Muto. EGFR inhibitors exert different effects on epithelial-like and mesenchymal-like esophageal squamous carcinoma cells. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. 2016. 31. 31-32
吉岡正博, 大橋真也, 菊池理, 玉置将司, 松原淳一, 森由希子, 宮本心一, 武藤学. 上皮様、間葉様の食道扁平上皮がんに対するEGFR阻害剤による分化誘導効果. 日本癌学会総会記事. 2016. 75回. P-1248
Osamu Kikuchi, Kiichiro Baba, Shinya Ohashi, Manabu Muto. Establishment of a 5-fluorouracil-resistant esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase gene amplification. CANCER RESEARCH. 2016. 76
Osamu Kikuchi, Shinya Ohashi, Yukie Nakai, Yusuke Amanuma, Masahiro Yoshioka, Shin'ichi Miyamoto, Mitsuteru Natsuizaka, Hiroshi Nakagawa, Tsutomu Chiba, Manabu Muto. Notch3-mediated squamous cell differentiation shows anti-tumor effect on esophageal squamous cell carcinoma as well as reduces its resistance to 5-Fluorouracil. CANCER RESEARCH. 2015. 75
菊池理, 大橋真也, 天沼裕介, 横山顕礼, 宮本心一, 松本繁巳, 武藤学. Notch3過剰発現による食道扁平上皮分化誘導は腫瘍造成能及び5FU抵抗性を抑制する. 日本食道学会学術集会プログラム・抄録集. 2015. 69回. 179-179

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Work history (5)：

2023/06 - 現在 Kyoto University Center for Cancer Immunotherapy and Immunobiology Associate Professor
2020/07 - 2023/06 Kyoto University Hospital Clinical Oncology Assistant Professor
2020/01 - 2020/07 Kyoto University Hospital Clinical Bio-Resource Center Assistant Professor
2019/10 - 2020/01 Kyoto University Hospital Clinical Oncology Attending physician
2016/10 - 2019/09 Dana-Farber Cancer Institute Medical Oncology Postdoctral Fellow

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