OKUNO Keisuke

Research field (2)： Tumor diagnostics and therapeutics , Digestive surgery

Research keywords (7)： microRNA , DNA methylation , Prognostic biomarker , Diagnostic biomarker , Esophageal cancer , Colorectal cancer , Gastric cancer

Research theme for competitive and other funds (3)：

2024 - 2027 The development of gene signature to predict recurrence and response of adjuvant chemotherapy in gastric cancer
2024 - 2025 Development of mycobiome-based prognostic biomarker for colorectal cancer
2023 - 2025 早期胃癌のリンパ節転移を予測するDNAメチル化バイオマーカーモデルの開発

Papers (34)：

Yoh Asahi, Caiming Xu, Keisuke Okuno, Akinobu Taketomi, Ajay Goel. The anticancer effects of Aronia berry extract are mediated by Chk1 and p53 in colorectal cancer. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024. 135. 156086-156086
Jun Sakuma, Akihiro Hoshino, Hisashi Fujiwara, Taichi Ogou, Kenro Kawada, Keisuke Okuno, Toshiro Tanioka, Shigeo Haruki, Masanori Tokunaga, Yusuke Kinugasa. Blood flow assessment of gastric tube with indocyanine green fluorescence angiography and postoperative endoscopy during esophagectomy: indocyanine green enhancement time indicated congestion. BMC gastroenterology. 2024. 24. 1. 316-316
Takashi Shigeno, Keisuke Okuno, Taichi Ogo, Hisashi Fujiwara, Toshiro Tanioka, Kenro Kawada, Shigeo Haruki, Masanori Tokunaga, Kiyohide Fushimi, Yusuke Kinugasa. Intraoperative recurrent laryngeal nerve monitoring for esophagectomy: A national cohort study. The Annals of thoracic surgery. 2024
Hisashi Fujiwara, Haruki Shigeo, Taichi Ogo, Kenro Kawada, Kazuya Yamaguchi, Masayoshi Sakano, Okuno Keisuke, Yuya Sato, Toshiro Tanioka, Masanori Tokunaga, et al. Novel reconstruction using pedicled ileocolic interposition with intrathoracic esophago-ileal anastomosis after distal esophagectomy for esophagogastric junction cancer: A report of two cases. Asian journal of endoscopic surgery. 2024. 17. 3. e13323
Keisuke Okuno, Shuichi Watanabe, Hoon Hur, Jeeyun Lee, Joon Oh Park, Masanori Tokunaga, Minoru Tanabe, Yusuke Kinugasa, Ajay Goel. An exosome-based liquid biopsy signature for therapeutic response prediction in metastatic gastric cancer. Clinical and translational medicine. 2024. 14. 7. e1629

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MISC (4)：

Keisuke Okuno, Masanori Tokunaga, Daniel Von Hoff, Yusuke Kinugasa, Ajay Goel. Intratumoral Malasseziaglobosa Levels Predict Survival and Therapeutic Response to Adjuvant Chemotherapy in Patients With Pancreatic Ductal Adenocarcinoma. Gastroenterology. 2023. 165. 2. 502-504
Keisuke Okuno, Raju Kandimalla, Marta Mendiola, Francesc Balaguer, Luis Bujanda, Carlos Fernandez-Martos, Jorge Aparicio, Jaime Feliu, Masanori Tokunaga, Yusuke Kinugasa, et al. A microRNA signature for risk-stratification and response prediction to FOLFOX-based adjuvant therapy in stage II and III colorectal cancer. Molecular cancer. 2023. 22. 1. 13-13
Katsuki Miyazaki, Yuma Wada, Keisuke Okuno, Tatsuro Murano, Yuji Morine, Tetsuya Ikemoto, Yu Saito, Hiroaki Ikematsu, Yusuke Kinugasa, Mitsuo Shimada, et al. An exosome-based liquid biopsy signature for pre-operative identification of lymph node metastasis in patients with pathological high-risk T1 colorectal cancer. Molecular cancer. 2023. 22. 1. 2-2
Mikito Inokuchi, Sho Otsuki, Norihito Ogawa, Toshiro Tanioka, Keisuke Okuno, Kentaro Gokita, Tatsuyuki Kawano, Kazuyuki Kojima. Postoperative Complications of Laparoscopic Total Gastrectomy versus Open Total Gastrectomy for Gastric Cancer in a Meta-Analysis of High-Quality Case-Controlled Studies. Gastroenterology research and practice. 2016. 2016. 2617903-2617903

Lectures and oral presentations (20)：

A mRNA-based signature to predict response of adjuvant chemotherapy in patients with gastric cancer
(The 79th General Meeting of the Japanese Society of Gastroenterological Surgery 2024)
DNA methylation-based liquid biopsy signature for the early detection of patients with pancreatic ductal adenocarcinoma
(Digestive Disease Week (DDW) 2024 2024)
A gene signature for recurrence prediction and risk-stratification of adjuvant chemotherapy in stage II and III gastric cancer
(2024)
The clinical factor model to predict postoperative complications after robotic gastrectomy
(2024)
The establishment of clinical factor model to predict postoperative complications after robotic gastrectomy for gastric cancer
(2023)

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Association Membership(s) (9)：

Society of Surgical Oncology , American Gastroenterological Association , Japan Society of Clinical Oncology , Japan Esophageal Society , Japanese Gastric Cancer Association , Japan Society for Endoscopic Surgery , Japan Gastroenterological Endoscopy Society , Japan Surgical Society , Japanese Society of Gastroenterological Surgery

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