Tomohiro Nishimura

ニシムラトモヒロ | Tomohiro Nishimura

Affiliation and department：
Job title： Former Associate Professor

Research field (1)： Clinical pharmacy

Research theme for competitive and other funds (15)：

2022 - 2025 子宮内膜螺旋動脈の成熟過程依存的な妊娠高血圧症候群に対する薬物療法の開発
2020 - 2022 Regulation of pharmacokinetics during pregnancy by placental exosomes
2018 - 2021 降圧薬同効薬間の有害事象報告頻度比較分析に基づく妊娠高血圧症治療薬開拓
2015 - 2018 Functional expression of sensing foctors against maternal osmotic stress in the placenta
2016 - 2017 Adverse fetal effect of thalidomide via semen

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Papers (55)：

Tomohiro Nishimura, Ryo Mizokami, Mayuko Yamanaka, Masaya Takahashi, Yuko Yoshida, Yuya Ogawa, Saki Noguchi, Masatoshi Tomi. Fetal ezrin expression affects macrophages and regulatory T cells in mouse placental decidua. Biochemical and Biophysical Research Communications. 2024. in press
Naomi Fukazawa, Tomohiro Nishimura, Keisuke Orii, Saki Noguchi, Masatoshi Tomi. Conversion of Olmesartan to Olmesartan Medoxomil, A Prodrug that Improves Intestinal Absorption, Confers Substrate Recognition by OATP2B1. Pharm Res. 2024. 41. 5. 849-861
Tomohiro Nishimura, Hikari Araki, Kei Higuchi, Saki Noguchi, Kei Saito, Kanako Hara, Haruya Yagishita, Risa Akashi, Sakiko Obata, Masatoshi Tomi. Involvement of GAT2/Slc6a13 in hypotaurine uptake at fetal-facing plasma membrane of syncytiotrophoblasts at mid-to-late gestation in rats and mice. Placenta. 2024. 147. 59-67
Tomohiro Nishimura, Mari Ishii, Hiroaki Tanaka, Saki Noguchi, Tomoaki Ikeda, Masatoshi Tomi. Breast Cancer Resistance Protein Limits Fetal Transfer of Tadalafil in Mice. J Pharm Sci. 2024. 113. 2. 486-492
Tomoya Akashi, Saki Noguchi, Yu Takahashi, Tomohiro Nishimura, Masatoshi Tomi. L-type Amino Acid Transporter 1 (SLC7A5)-Mediated Transport of Pregabalin at the Rat Blood-Spinal Cord Barrier and its Sensitivity to Plasma Branched-Chain Amino Acids. J Pharm Sci. 2023. 112. 4. 1137-1144

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MISC (34)：

西村友宏, 石井まり, 野口幸希, 田中博明, 池田智明, 登美斉俊. タダラフィルのマウス胎仔移行におけるBCRPの関与. 日本薬学会年会要旨集. 2022. 142年会. 26C-pm04
石井まり, 西村友宏, 野口幸希, 田中博明, 池田智明, 登美斉俊. タダラフィルおよびシルデナフィルのマウス胎仔移行性比較と胎盤透過制御機構. 日本妊娠高血圧学会雑誌. 2021. 27. 58-58
西村友宏. PDE5阻害剤は妊娠高血圧症の治療薬となるか. ファルマシア. 2020. 56. 8. 785-785
西村友宏, 野口幸希. 【「今さら聞けない」をスッキリ解消する妊娠・授乳と薬】[妊娠と薬]妊娠による生理学的変化と薬物動態. 薬事. 2020. 62. 4. 717-727
西村友宏, 野口幸希. 妊娠による生理学的変化と薬物動態. 薬事. 2020. 62. 4. 33-44

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Books (14)：

エピソード薬物動態学第2版 -薬物動態学の解明-
京都廣川書店 2023
別冊Newton くすりの科学知識改訂第3版
ニュートンプレス 2021 ISBN:9784315521894
今日のOTC薬改訂第5版
南江堂 2021 ISBN:9784524227129
わかりやすい薬物動態計算問題の解き方
ネオメディカル 2019 ISBN:9784904634271
今日のOTC薬改訂第4版
南江堂 2018 ISBN:9784524255726

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Lectures and oral presentations (356)：

OAT4介在輸送がアンジオテンシンII受容体拮抗薬(ARB)の経細胞透過に果たす役割
(日本薬学会第144年会)
Ezrin遺伝子欠損に伴う胎仔発育不全と胎盤免疫寛容の機能低下の関連解析
(日本薬学会第144年会)
Enhanced invasion of extravascular trophoblast cells by human vascular endothelial cells and its effect on gene expression
(Asian Federation for Pharmaceutical Sciences 2023)
Fetal transfer of tadalafil, a PDE5 inhibitor, is limited by BCRP at murine placental barrier
(Asian Federation for Pharmaceutical Sciences 2023)
Transport mechanism of propionic acid in human choriocarcinoma JEG-3 cells
(Asian Federation for Pharmaceutical Sciences 2023)

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Education (3)：

2005 - 2007 金沢大学大学院自然科学研究科博士後期課程
2003 - 2005 Kanazawa University Graduate School of Natural Science and Technology
1999 - 2003 Kanazawa University Faculty of Pharmaceutical Sciences Department of Pharmacy

Professional career (1)：

博士(薬学) (金沢大学)

Work history (7)：

2024/04 - 現在 Juntendo University Faculty of Pharmacy
2017/04 - 2024/03 Keio University Faculty of Pharmacy Associate Professor
2014/04 - 2017/03 Keio University Faculty of Pharmacy Senior Assitant Professor
2008/04 - 2014/03 Keio University Faculty of Pharmacy Assistant Professor
2011/09 - 2012/08 Mount Sinai School of Medicine Visiting Scientist

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Awards (4)：

2020 - Journal of Pharmaceutical Sciences 2020 Top Reviewers
2019/05 - 日本薬剤学会奨励賞胎児胎盤系の薬剤曝露制御と成長維持因子の研究
2019 - Journal of Pharmaceutical Sciences 2019 Top Reviewers
2019 - 日本妊娠高血圧学会学術奨励賞(基礎部門)

Association Membership(s) (10)：

創剤フォーラム , Asian Federation for Pharmaceutical Sciences (AFPS) , International Society for the Study of Xenobiotics (ISSX) , アジア薬科学連合 , 国際薬物動態学会 , 日本妊娠高血圧学会 , トランスポーター研究会 , 日本薬剤学会 , 日本薬物動態学会 , 日本薬学会

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