Okuyama Kazuki

Research theme for competitive and other funds (3)：

2020 - 2023 BCL11B変異によるヒト原発性免疫不全症発症機序の解明
2014 - 2016 Investigation of miRNA targeting Notch1
2010 - 2011 B細胞、T細胞分化をモデルとした、細胞分化・運命決定機構の解析

Papers (24)：

Kazuki Okuyama, Motoi Yamashita, Artemis Koumoundourou, Christoph Wiegreffe, Michiko Ohno-Oishi, Samuel J H Murphy, Xin Zhao, Hideyuki Yoshida, Takashi Ebihara, Naoko Satoh-Takayama, et al. A mutant BCL11B-N440K protein interferes with BCL11A function during T lymphocyte and neuronal development. Nature immunology. 2024
Kazuki Okuyama, Aneela Nomura, Kohei Nishino, Hirokazu Tanaka, Christelle Harly, Risa Chihara, Yasuyo Harada, Sawako Muroi, Masato Kubo, Hidetaka Kosako, et al. The Majority of the Serine/Threonine Phosphorylation Sites in Bcl11b Protein Are Dispensable for the Differentiation of T Cells. The Journal of Immunology. 2023. 210. 11. 1728-1739
幸谷愛, 黒崎なつみ, 長島悦子, 奥山一生, 山川奈津子, 緒方洵, 樋口廣士, 川島雅晴, 宮竹佑治, 亀田和明, et al. 悪性リンパ増殖疾患における腫瘍微小環境形成過程の究明とその制御による治療法開発(Investigation of tumor microenvironment formation in lymphoproliferative diseases and development of treatment). 日本癌学会総会記事. 2022. 81回. JWAS-1
Motoi Yamashita, Hye Sun Kuehn, Kazuki Okuyama, Satoshi Okada, Yuzaburo Inoue, Noriko Mitsuiki, Kohsuke Imai, Masatoshi Takagi, Hirokazu Kanegane, Masahiro Takeuchi, et al. A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS. Nature immunology. 2021. 22. 7. 893-903
Masaharu Kawashima, Joaquim Carreras, Hiroshi Higuchi, Ryutaro Kotaki, Takahiro Hoshina, Kazuki Okuyama, Naoto Suzuki, Masatoshi Kakizaki, Yuji Miyatake, Kiyoshi Ando, et al. PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma. Leukemia. 2020. 34. 9. 2405-2417

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MISC (8)：

那須亮, 奥山一生, 扇屋大輔, 穂積勝人, 村田暁彦, 安藤潔, 幸谷愛. 新たに同定されたNotchを標的とするmiRNAによるB細胞分化の制御とT-ALL治療の可能性. 日本癌学会総会記事. 2015. 74回. P-1137
Ai Sato, Natsuko Yamakawa, Kazuki Okuyama, Ai Kotani, Naoya Nakamura, Kiyoshi Ando. The Critical Interaction Between Epstein-Barr Virus (EBV) Positive B-Cells and Tumor Associated Macrophages (TAMs). BLOOD. 2014. 124. 21
Bidisha Chanda, Tomokatsu Ikawa, Kazuki Okuyama, Katsuto Hozumi, Kiyoshi Ando, Arinobu Tojo, Hiroshi Kawamoto, Ai Kotani. EBF Deficient Hematopoietic Progenitor Cells Potentialy Differentiated into Immature B Cell: EBF1 Dispensable for B Cell Linage Commitment from Pro-B to Pre-B Stage. BLOOD. 2014. 124. 21
Bidisha Chanda, Tomokatsu Ikawa, Kazuki Okuyama, Katsuto Hozumi, Kiyoshi Ando, Arinobu Tojo, Hiroshi Kawamoto, Ai Kotani. EBF Deficient Hematopoietic Progenitor Cells Potentialy Differentiated into Immature B Cell: EBF1 Dispensable for B Cell Linage Commitment from Pro-B to Pre-B Stage. BLOOD. 2014. 124. 21
Bidisha Chanda, Jun Ogata, Tomokatsu Ikawa, Kazuki Okuyama, Kiyoshi Ando, Arinobu Tojo, Ai Kotani. A Single Micro-RNA Can Completely Rescue B-Cell Differentiation Arrest Due To EBF1 Deficiency: Can Micro-RNA Control Cell Fate As a Potential Alternative Of Transcriptional Factor?. BLOOD. 2013. 122. 21

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