Rchr
J-GLOBAL ID：202001007562748289   Update date: Dec. 09, 2024

KIMURA HIROAKI

KIMURA HIROAKI
Research field  (1)： Orthopedics
Research keywords  (2)： musculoskeletal tumor ,  Bone metastasis
Research theme for competitive and other funds  (4)：
  • 2021 - 2024 Biological reaction in rat model with space making radiation therapy system for pediatric tumor
  • 2014 - 2017 Fluorescence imaging for investigation and treatment of bone and soft tissue tumors
  • 2013 - 2016 Correlation between cell cycle and chemotherapy resistance and lung metastases - Analysis using Fucci transfected sarcoma cells
  • 2011 - 2012 Relationship between lung metastases of osteosarcoma and coagulation-fibrinolytic factors
Papers (111)：
  • Sei Morinaga, Qinghong Han, Kohei Mizuta, Byung M Kang, Michael Bouvet, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, et al. Recombinant Methioninase Synergistically Reverses High-docetaxel Resistance Developed in Osteosarcoma Cells. Anticancer research. 2024. 44. 11. 4773-4778
  • Sei Morinaga, Qinghong Han, Kohei Mizuta, Byung Mo Kang, Motokazu Sato, Michael Bouvet, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, et al. Recombinant Methioninase Increases Eribulin Efficacy 16-fold in Highly Eribulin-resistant HT1080 Fibrosarcoma Cells, Demonstrating Potential to Overcome the Clinical Challenge of Drug-resistant Soft-tissue Sarcoma. Anticancer research. 2024. 44. 9. 3777-3783
  • Sei Morinaga, Qinghong Han, Kohei Mizuta, Byung M Kang, Motokazu Sato, Michael Bouvet, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, et al. Overcoming High Trabectedin Resistance of Soft-tissue Sarcoma With Recombinant Methioninase: A Potential Solution of a Recalcitrant Clinical Problem. Anticancer research. 2024. 44. 9. 3785-3791
  • Sei Morinaga, Qinghong Han, Kohei Mizuta, Byung Mo Kang, Motokazu Sato, Michael Bouvet, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, et al. Recombinant Methioninase Is Selectively Synergistic With Doxorubicin Against Wild-type Fibrosarcoma Cells Compared to Normal Cells and Overcomes Highly-Doxorubicin-resistant Fibrosarcoma. Anticancer research. 2024. 44. 8. 3261-3268
  • Sei Morinaga, Qinghong Han, Yutaro Kubota, Kohei Mizuta, Byung Mo Kang, Motokazu Sato, Michael Bouvet, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, et al. DNA-Binding Agent Trabectedin Combined With Recombinant Methioninase Is Synergistic to Decrease Fibrosarcoma Cell Viability and Induce Nuclear Fragmentation But Not Synergistic on Normal Fibroblasts. Anticancer research. 2024. 44. 6. 2359-2367
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MISC (24)：
  • Takashi Higuchi, Kentaro Igarashi, Hiromichi Oshiro, Kentaro Miyake, Norihiko Sugisawa, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Zhenfeng Duan, et al. Patient-derived orthotopic xenograft models for osteosarcoma individualized precision treatment and effective drug discovery. Annals of Joint. 2021. 6
  • 樋口 貴史, 山本 憲男, 林 克洋, 木村 浩明, 武内 章彦, 三輪 真嗣, 五十嵐 健太郎, 米澤 宏隆, 森永 整, 荒木 麗博, et al. 軟部肉腫に対するolaratumabの可能性 patient-derived orthotopic xenograft(PDOX)マウスモデルによる解析. 日本整形外科学会雑誌. 2020. 94. 8. S1985-S1985
  • 青木 裕, 山本 憲男, 林 克洋, 木村 浩明, 武内 章彦, 三輪 真嗣, 五十嵐 健太郎, 稲谷 弘幸, 谷口 裕太, 米澤 宏隆, et al. 脂肪由来幹細胞を用いた凍結自家処理骨移植後の再生促進作用の検討. 日本生体電気・物理刺激研究会誌. 2019. 33. 54-54
  • 青木 裕, 山本 憲男, 林 克洋, 木村 浩明, 武内 章彦, 三輪 真嗣, 五十嵐 健太郎, 稲谷 弘幸, 谷口 裕太, 米澤 宏隆, et al. 脂肪由来幹細胞を用いた凍結自家処理骨移植後の再生促進作用の検討. 日本生体電気・物理刺激研究会誌. 2019. 33. 54-54
  • 青木 裕, 山本 憲男, 林 克洋, 木村 浩明, 武内 章彦, 三輪 真嗣, 五十嵐 健太郎, 稲谷 弘幸, 阿部 健作, 谷口 裕太, et al. 脂肪由来幹細胞による凍結自家処理骨移植後の再生促進作用の検討. 日本整形外科学会雑誌. 2018. 92. 6. S1457-S1457
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Education (2)：
  • 2002 - 2011 Kanazawa University Graduate School of Medical Science
  • 1996 - 2002 Kanazawa University
Work history (6)：
  • 2020/10 - 現在 Nagoya City University Graduate School of Medical Sciences Department of Orthopedic Surgery
  • 2016/04 - 2020/10 Kanazawa RedCross Hospital Orthopedic Surgery
  • 2014/04 - 2016/03 Nagoya City University Graduate School of Medical Sciences Department of Orthopedic Surgery
  • 2011/09 - 2014/03 Kanazawa University Orthopedic Surgery
  • 2010/06 - 2011/08 Kanazawa University Orthopedic Surgery
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