Rchr
J-GLOBAL ID：202001008027717672
Update date: Apr. 02, 2024
Yamashita Takuma
Yamashita Takuma
Affiliation and department：
Research theme for competitive and other funds (5)：
- 2022 - 2024 ゲノム編集細胞におけるオフターゲット変異の高感度検出法ClAmp-seqの確立
- 2022 - 2023 RNA製品の品質・安全性評価法の確立
- 2022 - 2023 遺伝子治療用製品の設計/製造方法変更に伴う品質・安全性評価に関する研究
- 2020 - 2022 ゲノム編集に伴い意図せず編集されうる塩基配列条件の解明
- 2017 - 2019 RNA医薬のデリバリーを目的とした標的指向性RNA封入エキソソームの開発
Papers (5)：
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Takuma Yamashita, Haruka Shinotsuka, Yuki Takahashi, Kana Kato, Makiya Nishikawa, Yoshinobu Takakura. SELEX-Based Screening of Exosome-Tropic RNA. Biological and Pharmaceutical Bulletin. 2017. 40. 12. 2140-2145
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Takuma Yamashita, Yuki Takahashi, Makiya Nishikawa, Yoshinobu Takakura. Effect of exosome isolation methods on physicochemical properties of exosomes and clearance of exosomes from the blood circulation. European Journal of Pharmaceutics and Biopharmaceutics. 2016. 98. 1-8
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Masaki Morishita, Yuki Takahashi, Makiya Nishikawa, Kohei Sano, Kana Kato, Takuma Yamashita, Takafumi Imai, Hideo Saji, Yoshinobu Takakura. Quantitative analysis of tissue distribution of the B16BL6-derived exosomes using a streptavidin-lactadherin fusion protein and iodine-125-labeled biotin derivative after intravenous injection in mice. Journal of pharmaceutical sciences. 2015. 104. 2. 705-13
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Takafumi Imai, Yuki Takahashi, Makiya Nishikawa, Kana Kato, Masaki Morishita, Takuma Yamashita, Akihiro Matsumoto, Chonlada Charoenviriyakul, Yoshinobu Takakura. Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice. Journal of extracellular vesicles. 2015. 4. 1. 26238-26238
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Mitsuru Ando, Yuki Takahashi, Takuma Yamashita, Mai Fujimoto, Makiya Nishikawa, Yoshihiko Watanabe, Yoshinobu Takakura. Prevention of adverse events of interferon γ gene therapy by gene delivery of interferon γ-heparin-binding domain fusion protein in mice. Molecular Therapy - Methods and Clinical Development. 2014. 1. 14023-14023
MISC (5)：
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吉田 徳幸, 山下 拓真, 山本 武範, 大岡 伸通, 位高 啓史, 秋田 英万, 武下 文彦, 峰野 純一, 辻畑 茂朝, 山口 照英, et al. mRNA医薬の評価の考え方 -パネルディスカッションの論点-. 医薬品医療機器レギュラトリーサイエンス. 2023. 54. 4. 322-329
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Takenori YAMAMOTO, Eriko UCHIDA, Takuma YAMASHITA, Takao INOUE. International Regulatory Trends of the Quality and Safety of Gene Therapy Products and Genetically Modified Cell-based Products. 2022. 53. 2. 72-84
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Immune responses involved in the efficacy and safety of gene therapy using adeno-associated virus vectors. PHARM TECH JAPAN. 2021. 37. 15. 2645-2651
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Eriko Uchida, Takuma Yamashita, Ryuichi Ono, Yuki Naito, Task Force for Safety Assessment of Genome Editing Therapy, Takao Inoue. Regulations and Safety Evaluation for Genome Editing Therapy. Pharmaceutical and Medical Device Regulatory Science. 2019. 50. 9. 513-522
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Takuma Yamashita, Yuki Takahashi, Yoshinobu Takakura. Possibility of Exosome-Based Therapeutics and Challenges in Production of Exosomes Eligible for Therapeutic Application. Biological and Pharmaceutical Bulletin. 2018. 41. 6. 835-842
Books (4)：
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遺伝子治療用製品の開発・申請戦略<承認取得に向けた規制対応と品質及び安全性の確保>
サイエンス&テクノロジー 2023
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遺伝子治療用製品の開発・申請戦略<承認取得に向けた規制対応と品質及び安全性の確保>
サイエンス&テクノロジー 2023
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遺伝子治療用製品の開発・申請戦略<承認取得に向けた規制対応と品質及び安全性の確保>
サイエンス&テクノロジー 2023 ISBN:9784864283137
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ゲノム編集の最新技術と医薬品・遺伝子治療・農業・水畜産物 ・有用物質生産への活用
技術情報協会 2023 ISBN:9784861049781
Lectures and oral presentations (27)：
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薬学研究者としてのはじまりとこれから
(日本薬学会第144年会 2024)
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Regulatory science research on evaluation methods for full-length mRNA content of mRNA medicines
(2024)
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Investigation of the effect of clamp nucleic acid modification sites on amplification suppression in clamp PCR
(2024)
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キャピラリーゲル電気泳動によるmRNAの分離分析に影響を及ぼす分析パラメータの抽出
(国立医薬品食品衛生研究所 島津製作所 第3回技術交流会 2023)
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mRNA医薬の全長mRNA含有率評価法に関する研究
(第60回全国衛生化学技術協議会年会 2023)
ｍore...
Education (2)：
- 2015 - 2019 Kyoto University Graduate School of Pharmaceutical Sciences
- 2009 - 2015 Kyoto University Faculty of Pharmaceutical Sciences
Professional career (1)：
Work history (5)：
- 2021/04 - 現在 National Institute of Health Sciences Division of Molecular Target and Gene Therapy Products
- 2019/08 - 2021/03 Japan Agency for Medical Research and Development
- 2019/08 - 2021/03 National Institute of Health Sciences Division of Molecular Target and Gene Therapy Products Postdoctoral fellow
- 2019/04 - 2019/07 Kyoto University Graduate School of Pharmaceutical Sciences Postdoctoral fellow
- 2017/04 - 2019/03 Japan Society for the Promotion of Science Research Fellowship for Young Scientists
Awards (2)：
- 2024/03 - 公益社団法人 日本薬学会 長井記念若手薬学研究者賞
- 2023/03 - 2022 Highly Cited Review Award for Biological and Pharmaceutical Bulletin Possibility of Exosome-Based Therapeutics and Challenges in Production of Exosomes Eligible for Therapeutic Application
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