Seya Daiki

セヤダイキ | Seya Daiki

Affiliation and department：
Job title： Assistant professor

Research field (4)： Fetal medicine/Pediatrics , Cardiology , Physiology , Medical biochemistry

Research keywords (6)： congenital heart disease , transcription factor , retinoic acid , neural crest cells , cardiac development , pathophysiology

Research theme for competitive and other funds (8)：

2025 - 2028 心室中隔形成における神経堤細胞の役割とその分子基盤の解析
2022 - 2025 遺伝子改変マウスモデルを用いた肺静脈性肺高血圧症の病態解明および新規治療法の探索
2019 - 2022 Molecular mechanisms of cell differentiation during development of great vessels and ventricles
2019 - 2022 Ventricular transcription factor cascade in the formation of atrioventricular valve and septum during embryonic heart development
2018 - 2021 Significance of cellular signaling pathways in cardiovascular development and disease

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Papers (9)：

Shunsuke Baba, Satoko Shinjo, Daiki Seya, Hiroki Bochimoto, Toru Akaike, Atsushi Nakano, Susumu Minamisawa. Transgenic mice overexpressing Pitx2 in the atria develop tachycardia-bradycardia syndrome. PLOS One. 2025. 20. 9. e0330397
Daiki Seya, Yuqing Xu, Toshifumi Mukunoki, Kenichi Tsujita, Osamu Nakagawa, Yuichiro Arima. Sample Preparation for Computed Tomography-based Three-dimensional Visualization of Murine Hind-limb Vessels. Journal of visualized experiments : JoVE. 2021. 176
Daiki Seya, Dai Ihara, Manabu Shirai, Teruhisa Kawamura, Yusuke Watanabe, Osamu Nakagawa. A role of Hey2 transcription factor for right ventricle development through regulation of Tbx2-Mycn pathway during cardiac morphogenesis. Development, growth & differentiation. 2021. 63. 1. 82-92
Yusuke Watanabe, Daiki Seya, Dai Ihara, Shuhei Ishii, Taiki Uemoto, Atsushi Kubo, Yuji Arai, Yoshie Isomoto, Atsushi Nakano, Takaya Abe, et al. Importance of endothelial Hey1 expression for thoracic great vessel development and its distal enhancer for Notch-dependent endothelial transcription. The Journal of biological chemistry. 2020. 295. 51. 17632-45
Dai Ihara, Yusuke Watanabe, Daiki Seya, Yuji Arai, Yoshie Isomoto, Atsushi Nakano, Atsushi Kubo, Toshihiko Ogura, Teruhisa Kawamura, Osamu Nakagawa. Expression of Hey2 transcription factor in the early embryonic ventricles is controlled through a distal enhancer by Tbx20 and Gata transcription factors. Developmental biology. 2020. 461. 2. 124-31

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MISC (2)：

Daiki Seya, Takahiro Inoue, Shunsuke Baba, Toru Akaike, Susumu Minamisawa. Abstract 16402: Pitx2c-Conditional Knockout Mice May Become a Useful Model to Elucidate the Pathogenesis of Post-Capillary Pulmonary Hypertension. Circulation. 2023. 148. Suppl_1
Rieko Asai, Yuichiro Arima, Daiki Seya, Ki-Sung Kim, Yumiko Kawamura, Yukiko Kurihara, Sachiko Miyagawa-Tomita, Hiroki Kurihara. Endothelin Receptor Type A-Expressing Cell Population in the Inflow Tract Contributes to Chamber Formation. 2016. 289-90

Lectures and oral presentations (2)：

Pitx2c-conditional knockout mice may become a useful model to elucidate the pathogenesis of post-capillary pulmonary hypertension
(American Heart Association Scientific Sessions 2023 2023)
Pitx2c-conditional knockout mice may become a useful model for understanding the pathogenesis of post-capillary pulmonary hypertension
(The 10th Federation of the Asian and Oceanian Physiological Societies Congress 2023)

Education (1)：

Professional career (1)：

Work history (4)：

2024/04 - 現在 National Defense Medical College Assistant professor
2020/04 - 2024/03 Jikei University School of Medicine Postdoctoral researcher
2017/04 - 2020/03 National Cerebral and Cardiovascular Center, Research Institute Postdoctoral researcher
2014/04 - 2017/03 Japan Society for the Promotion of Science Research fellow

Committee career (1)：

Awards (2)：

2023/08 - Federation of the Asian and Oceanian Physiological Societies(FAOPS) K-MEDI hub Young Investigator Award / Young Investigator Travel Grant, FAOPS 2023 Congress
2022/06 - Japanese Society of Developmental Biologists Development, Growth & Differentiation(DGD)Young Investigator Paper Award 2022

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