Ichiyama Kenji

イチヤマケンジ | Ichiyama Kenji

Affiliation and department：

Research field (2)： Molecular biology , Immunology

Research theme for competitive and other funds (16)：

2024 - 2028 Elucidation of the mechanism of Treg dysfunction by Ikzf1 mutation and development of a new therapy for autoimmune diseases
2024 - 2027 Study on the development and function of regulatory T cells and their application to the treatment of immunological diseases
2025 - 2026 制御性T細胞の活性化における新規Foxp3結合因子Bcl11bの機能およびその制御機構の解明
2021 - 2024 Foxp3結合因子Ikzf1を標的とした新たな免疫応答制御法開発のための基盤研究
2020 - 2022 制御性 T 細胞における新規 Foxp3 共役因子の同定およびその機能解明

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Papers (27)：

Kenji Ichiyama, Jia Long, Yusuke Kobayashi, Yuji Horita, Takeshi Kinoshita, Yamami Nakamura, Chizuko Kominami, Katia Georgopoulos, Shimon Sakaguchi. Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity. Immunity. 2024. 57. 9. 2043-2060
Yutaka Kurebayashi, Shigenori Nagai, Ai Ikejiri, Masashi Ohtani, Kenji Ichiyama, Yukiko Baba, Taketo Yamada, Shohei Egami, Takayuki Hoshii, Atsushi Hirao, et al. Correction: PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ. Cell reports. 2021. 34. 12
Shimon Sakaguchi, Norihisa Mikami, James B Wing, Atsushi Tanaka, Kenji Ichiyama, Naganari Ohkura. Regulatory T Cells and Human Disease. Annual review of immunology. 2020. 38. 541-566
Kenji Ichiyama, Chen Dong. The role of miR-183 cluster in immunity. Cancer letters. 2019. 443. 108-114
Kentaro Tanaka, Gustavo J Martinez, Xiaowei Yan, Weiwen Long, Kenji Ichiyama, Xinxin Chi, Byung-Seok Kim, Joseph M Reynolds, Yeonseok Chung, Shinya Tanaka, et al. Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3. Cell reports. 2018. 23. 8. 2318-2329

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MISC (11)：

The microRNA-183 cluster promotes Th17 cell pathogenicity by negatively regulating transcription factor Foxo1 expression. 2017. 67. 5. 513-518
市山健司, 坂口志文. 最新免疫学×周産期医学基礎医学-免疫学の最初の一歩制御性T細胞. 周産期医学. 2017. 47. 12
市山健司, Chen Dong. miR-183クラスターは転写因子Foxo1の発現を負に制御することによりTh17細胞の病原性を促進する. ライフサイエンス新着論文レビュー. 2016
Akihiko Yoshimura, Kenji Ichiyama, Ikko Kashiwagi. Role of TGF-beta-Smad2/3 signaling in helper T cell function and differentiation. CYTOKINE. 2011. 56. 1. 20-20
市山健司, 吉村昭彦. TGF-betaによるSmadに非依存性のTh17細胞の分化誘導は転写因子Eomesの抑制を介する. ライフサイエンス新着論文レビュー. 2011

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Patents (1)：

Lectures and oral presentations (19)：

Foxp3 依存的遺伝子発現制御における Foxp3-Ikzf1 相互作用の役割:相互作用阻害による自己免疫と腫瘍免疫の誘導
(第33回Kyoto T Cell Conference)
Foxp3 は転写因子 Ikzf1 との相互作用を介して制御性 T 細胞の機能安定性を制御する
(日本薬学会第144年会)
Ikzf1 association with Foxp3 for Foxp3-dependent gene repression in Treg cells: disruption of the association causes autoimmunity
(Keystone Symposia on Molecular and Cellular Biology [Systemic Autoimmune and Autoinflammatory Diseases (B2)] 2024)
MBD3 Facilitates Thymic Treg Precursor Development and Treg Lineage Commitment by Altering CD25 Expression
(2023)
Exon 5 of Ikzf1 is required for Foxp3-dependent gene suppression to maintain the homeostasis of regulatory T cells
(2022)

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Education (4)：

2008 - 2009 九州大学大学院医学系学府病態医学専攻特別研究員DC2
2006 - 2008 Kyushu University
2004 - 2006 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences
2000 - 2004 Okayama University Faculty of Pharmaceutical Sciences Department of Pharmacy

Professional career (1)：

Work history (7)：

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Awards (5)：

Association Membership(s) (4)：

日本薬学会 , 日本生化学会 , 日本分子生物学会 , 日本免疫学会

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