OZAKI Fumiko

Research field (1)： Immunology

Research theme for competitive and other funds (5)：

2024 - 2027 PSTPIP1関連炎症性疾患に着目した難治性皮膚疾患の病態形成機構解明と治療法開発
2021 - 2024 好中球異常を伴う自己炎症性疾患の病態解明と治療法開発
2021 - 2024 Research on the functional assignment of the IKZF transcription factor by structural difference and on the modulation of transcriptional regulation by mutations in the IKZF1 molecule
2017 - 2019 疾患iPS/ES細胞を用いた自己炎症性疾患(中條-西村症候群)の病態解析
2013 - 2017 iPS細胞を用いた小児免疫疾患の病態解析と治療法の探索

Papers (16)：

Manabu Sugie, Nobutoshi Nawa, Yusuke Noguchi, Atsuko Taki, Ayako Kashimada, Izumi Honda, Akira Koyama, Kaoru Okazaki, Masatoshi Kondo, Hiroyuki Miyahara, et al. Stage III Chorioamnionitis is Associated with Reduced Risk of Severe Retinopathy of Prematurity. The Journal of pediatrics. 2024. 272. 114085-114085
Takayuki Miyamoto, Kazushi Izawa, Sho Masui, Atsue Yamazaki, Yuichi Yamasaki, Tadashi Matsubayashi, Mayuka Shiraki, Hidenori Ohnishi, Junko Yasumura, Tomohiro Kawabe, et al. Clinical Characteristics of Cryopyrin-Associated Periodic Syndrome and Long-Term Real-World Efficacy and Tolerability of Canakinumab in Japan: Results of a Nationwide Survey. Arthritis & Rheumatology. 2024. 76. 6. 949-962
Iki Sonn, Fumiko Honda-Ozaki, Sho Yoshimatsu, Satoru Morimoto, Hirotaka Watanabe, Hideyuki Okano. Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia. Inflammation and regeneration. 2022. 42. 1. 20-20
Naoya Kase, Madoka Terashima, Akira Ohta, Akira Niwa, Fumiko Honda-Ozaki, Yuri Kawasaki, Tatsutoshi Nakahata, Nobuo Kanazawa, Megumu K Saito. Pluripotent stem cell-based screening identifies CUDC-907 as an effective compound for restoring the in vitro phenotype of Nakajo-Nishimura syndrome. Stem cells translational medicine. 2021. 10. 3. 455-464
Kayo Kunimoto, Fumiko Honda-Ozaki, Megumu K Saito, Fukumi Furukawa, Nobuo Kanazawa. Beneficial effect of methotrexate on a child case of Nakajo-Nishimura syndrome. The Journal of dermatology. 2019. 46. 10. e365-e367

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MISC (1)：

本田富美子. ヒトC3欠損症における免疫学的異常. 月刊リウマチ科. 2009. 42. 4

Lectures and oral presentations (15)：

フローサイトメトリーによるライソゾーム酸性リパーゼ欠損症の簡易診断法の開発.
(第127回日本小児科学会学術集会 2024)
疾患特異的 iPS細胞を用いたPAMI症候群の病態モデルを用いたカルプロテクチン抑制療法の検討
(第 6 回日本免疫不全・自己炎症学会総会・学術集会 2023)
Pathophysiological analysis and therapeutic exploration using PSTPIP1-associated myeloproteinemia inflammation (PAMI) syndrome disease-specific induced pluripotent stem cell model
(20th Meeting of the European Society for Immunodeficiencie (ESID) 2022)
本邦で発見したB細胞欠損女児における新奇SLC39A7遺伝子変異とZIP7機能異常.
(第5回日本免疫不全・自己炎症学会総会 2022)
Aberrant Neutrophil Function in PSTPIP1 mutations
(2017)

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Awards (3)：

2023/06 - 公益財団法人森永奉仕会森永奉仕会研究奨励金特別賞太田敬三記念賞炎症性皮膚疾患の分子病態解明と治療法の検討
2023/02 - 第6回日本免疫不全・自己炎症学会総会最優秀演題疾患特異的iPS細胞を用いたPAMI症候群の病態モデルを用いたカルプロテクチン抑制療法の検討
2012/02 - 公益財団法人井上科学振興財団井上研究奨励賞 Btkによる好中球の活性酸素産生及びアポトーシスの制御

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