J-GLOBAL ID:202001010113454921   Update date: Apr. 19, 2024

Metwally Hozaifa

Metwally Hozaifa | Metwally Hozaifa
Affiliation and department:
Job title: Assistant Professor
Research field  (2): Molecular biology ,  Immunology
Research keywords  (1): gene regulation, host defense, infection, inflammation
Research theme for competitive and other funds  (1):
  • 2019 - 2021 Unveiling Novel STAT1 Activation Expands its Anti-viral Role into Host Defense Against Bacterial Pathogens
Papers (11):
  • Hozaifa Metwally, Maha M Elbrashy, Tatsuhiko Ozawa, Kazuki Okuyama, Jason T White, Janyerkye Tulyeu, Jonas Nørskov Søndergaard, James Badger Wing, Arisa Muratsu, Hisatake Matsumoto, et al. Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 17. e2402226121
  • Kishan Kumar Nyati, Shigeru Hashimoto, Shailendra Kumar Singh, Murat Tekguc, Hozaifa Metwally, Yu-Chen Liu, Daisuke Okuzaki, Yohannes Gemechu, Sujin Kang, Tadamitsu Kishimoto. The novel long noncoding RNA AU021063, induced by IL-6/Arid5a signaling, exacerbates breast cancer invasion and metastasis by stabilizing Trib3 and activating the Mek/Erk pathway. Cancer Letters. 2021. 520. 295-306
  • Gyanu Parajuli, Murat Tekguc, James B. Wing, Ari Hashimoto, Daisuke Okuzaki, Takeshi Hirata, Atsushi Sasaki, Takahide Itokazu, Haruka Handa, Hirokazu Sugino, et al. Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression. Cancer Immunology Research. 2021. 9. 8. 862-876
  • The Yin and the Yang of STAT1 Downstream of TLR4 Endocytosis: STAT1 beyond Interferon Signaling. Journal of Cellular Immunology. 2020. 2. 5
  • Distinct Phosphorylation of STAT1 Confers Distinct DNA Binding and Gene-regulatory Properties. Journal of Cellular Signaling. 2020. 1. 3
MISC (1):
  • Hozaifa Metwally, Toshio Tanaka, Tadamitsu Kishimoto. Arid5a expression is induced through MYD88-independent pathway in response to TLR4 stimulation in IFNy-sensitized human macrophages.'. JOURNAL OF IMMUNOLOGY. 2017. 198. 1
Lectures and oral presentations  (3):
  • STAT1 displays functionally distinct phosphorylation upon LPS stimulation
    (The 45th IFReC Colloquium 2020)
    (7th Annual Meeting of the International Cytokine & Interferon Society, Vienna 2019 2019)
  • Arid5a expression is induced through MYD88-independent pathway in response to TLR4 stimulation in IFNγ-sensitized human macrophages
    (The 7th NIF Winter School on Advanced Immunology, Awajii island, Japan 2018 2018)
Education (2):
  • 2015 - 2018 Graduate School of Frontier Biosciences, Osaka University PhD
  • 2007 - 2015 Faculty Of Medicine, Suez Canal University MD
Professional career (2):
  • PhD (Osaka University)
  • MBBCh (Suez Canal University)
Work history (4):
  • 2022/04 - 現在 Osaka University WPI Immunology Frontier Research Center Assistant Professor
  • 2020/05 - 2022/03 Osaka University WPI Immunology Frontier Research Center Advanced Postdoc
  • 2019/01 - 2020/04 Osaka University WPI Immunology Frontier Research Center Kishimoto Foundation Postdoctoral Fellow
  • 2015/11 - 2018/12 Osaka University WPI Immunology Frontier Research Center Specially Appointed Researcher (Part-time)
Awards (1):
  • 2019/10 - The International Cytokine & Interferon Society Milstein Travel Award
Association Membership(s) (2):
International Cytokine & Interferon Society (ICIS) ,  American Association of Immunologists (AAI)
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