Rchr
J-GLOBAL ID：202001010504227849
Update date: Sep. 11, 2024
Onizuka Shin
オニヅカ シン | Onizuka Shin
Affiliation and department：
Job title：
professor
Research field (5)：
Immunology
, Anesthesiology
, Animals: biochemistry, physiology, behavioral science
, Cell biology
, Molecular biology
Research keywords (2)：
Tumor Immunity
, 局所麻酔薬
Research theme for competitive and other funds (12)：
- 2022 - 2025 Examination of anesthetics that are advantageous for tumor immunity targeting cancer specific antigens, cancer specific antigens
- 2018 - 2021 Elucidation of DNA demethylation mechanism of local anesthetic and its usefulness for anesthesia, cancer treatment, regenerative medicine.
- 2015 - 2018 Search of optimal anesthetic in cancer patients was evaluated from apoptosis induced cancer cells
- 2012 - 2012 局所麻酔薬のDNA脱メチル化による腫瘍細胞増殖抑制および致死機序の解明
- 2009 - 2011 The mechanisms of lidocaine induce apoptosis in cancer cells
- 2008 - 2010 腫瘍分泌生理活性物質によるシナプス伝達機構の修飾
- 2007 - 2008 The mechanism of local anesthetics induced convulsion
- 2005 - 2006 Effect of sevoflurane on the voltage-dependent sodium currents in a Lymnaea neuron
- 2005 - 2006 Effects of local anesthetics on the soma and axon in cultured neuron of Lymnaea stagnalis
- 2000 - 2001 神経成長因子の神経細胞シナプス再構築過程への影響
- 1999 - 2000 Effect of volatile anesthetics on Cultured Neuron of Lymnaea stagnalis
- 1995 - 1995 NMDA投与による痛みの慢性化に関する研究
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Papers (18)：
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Onizuka S, Ikewaki N, Shiraishi S. Journal of Drug Metabolism & Toxicology. 2017
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Ryuji Tamura, Takayuki Nemoto, Toyoaki Maruta, Shin Onizuka, Toshihiko Yanagita, Akihiko Wada, Manabu Murakami, Isao Tsuneyoshi. Up-regulation of NaV1.7 sodium channels expression by tumor necrosis factor-α in cultured bovine adrenal chromaffin cells and rat dorsal root ganglion neurons. Anesthesia and analgesia. 2014. 118. 2. 318-24
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Shin Onizuka, Seiji Shiraishi, Ryuuji Tamura, Tetsu Yonaha, Nobuko Oda, Yuko Kawasaki, Naweed I Syed, Tetsuro Shirasaka, Isao Tsuneyoshi. Lidocaine treatment during synapse reformation periods permanently inhibits NGF-induced excitation in an identified reconstructed synapse of Lymnaea stagnalis. Journal of anesthesia. 2012. 26. 1. 45-53
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Shin Onizuka, Ryuji Tamura, Tetsu Yonaha, Nobuko Oda, Yuko Kawasaki, Tetsuro Shirasaka, Seiji Shiraishi, Isao Tsuneyoshi. Clinical dose of lidocaine destroys the cell membrane and induces both necrosis and apoptosis in an identified Lymnaea neuron. Journal of anesthesia. 2012. 26. 1. 54-61
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Shin Onizuka, Tetsu Yonaha, Ryuji Tamura, Masatoshi Kasiwada, Toshiro Shirasaka, Isao Tsuneyoshi. Lidocaine depolarizes the mitochondrial membrane potential by intracellular alkalization in rat dorsal root ganglion neurons. Journal of anesthesia. 2011. 25. 2. 229-39
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Education (1)：
Professional career (1)：
Association Membership(s) (4)：
日本臨床麻酔学会
, 日本ペインクリニック学会
, 日本集中治療学会
, 日本麻酔科学会
