Rchr
J-GLOBAL ID：202001010594385383   Update date: Jul. 16, 2024

NAKAGAWA Osamu

ナカガワ オサム | NAKAGAWA Osamu
Affiliation and department：
National Cerebral and Cardiovascular Center Research Institute Department of Genomic Medicine

About National Cerebral and Cardiovascular Center Research Institute Department of Genomic Medicine


Other affiliations (2)：
Research field  (3)： Developmental biology ,  Cardiology ,  Fetal medicine/Pediatrics
Research keywords  (5)： Cardiovascular development ,  Signal transduction ,  Transcription factor ,  Congenital heart disease ,  Intractable vascular disease
Research theme for competitive and other funds  (23)：
  • 2023 - 2026 心臓発生期のゲノム網羅的エンハンサーアトラスと心臓内領域特異的遺伝子発現制御機構
  • 2022 - 2025 ALK1シグナルの臓器特異的血管形成における意義と難治性血管疾患の発症メカニズム
  • 2022 - 2025 心室筋細胞特異的な分化運命決定および転写制御機構の解明
  • 2021 - 2024 Downstream genes of signaling pathways implicated in human cardiovascular diseases: in vivo significance and regulatory mechanisms
  • 2020 - 2023 Integrated analysis of pathgenesis of hereditary hemorrhagic telangiectasia
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Papers (98)：
  • Yusuke Watanabe, Yunce Wang, Yuki Tanaka, Akiyasu Iwase, Teruhisa Kawamura, Yumiko Saga, Kenta Yashiro, Hiroki Kurihara, Osamu Nakagawa. Hey2 enhancer activity defines unipotent progenitors for left ventricular cardiomyocytes in juxta-cardiac field of early mouse embryo. Proceedings of the National Academy of Sciences. 2023. 120. 37
  • Toru Iwasa, Akihiro Urasaki, Yuki Kakihana, Nami Nagata-Akaho, Yukihiro Harada, Soichi Takeda, Teruhisa Kawamura, Isao Shiraishi, Kenichi Kurosaki, Hiroko Morisaki, et al. Computational and Experimental Analyses for Pathogenicity Prediction of ACVRL1 Missense Variants in Hereditary Hemorrhagic Telangiectasia. Journal of Clinical Medicine. 2023. 12. 15. 5002-5002
  • Takahiro Sogo, Shu Nakao, Tasuku Tsukamoto, Tomoe Ueyama, Yukihiro Harada, Dai Ihara, Tomoaki Ishida, Masato Nakahara, Koji Hasegawa, Yuka Akagi, et al. Canonical Wnt signaling activation by chimeric antigen receptors for efficient cardiac differentiation from mouse embryonic stem cells. Inflammation and regeneration. 2023. 43. 1. 11-11
  • Daiki Seya, Yuqing Xu, Toshifumi Mukunoki, Kenichi Tsujita, Osamu Nakagawa, Yuichiro Arima. Sample Preparation for Computed Tomography-based Three-dimensional Visualization of Murine Hind-limb Vessels. Journal of visualized experiments : JoVE. 2021. 176
  • Yukihiro Harada, Toru Tanaka, Yuji Arai, Yoshie Isomoto, Atsushi Nakano, Shu Nakao, Akihiro Urasaki, Yusuke Watanabe, Teruhisa Kawamura, Osamu Nakagawa. ETS-dependent enhancers for endothelial-specific expression of serum/glucocorticoid-regulated kinase 1 during mouse embryo development. Genes to cells : devoted to molecular & cellular mechanisms. 2021. 26. 8. 611-626
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MISC (40)：
  • 三好剛一, 久光隆, 渡邉裕介, 中川修, 細田洋司. 胎児心疾患モデルマウスに対する経胎盤的PDE5阻害剤投与の有効性. 超音波医学. 2018. 45. Supplement (CD-ROM). S708(J-STAGE)-S708
  • 渡邉 裕介, 石井 修平, 深山 俊治, 上本 泰生, 井原 大, 西谷 友重, 荒井 勇二, 中川 修. 咽頭弓および未分節中胚葉におけるHey1遺伝子の発現は遠位エンハンサーにより制御される. 生命科学系学会合同年次大会. 2017. 2017年度. [4LT12-02(3P
  • 片山 由美, 冨松 彩佳, 渡邉 裕介, 瀬谷 大貴, 荒井 勇二, 磯本 祥恵, 斎藤 能彦, 中川 修. 胎生期血管内皮遺伝子Tmem100の心血管形態形成における発現制御機構の解析. 生命科学系学会合同年次大会. 2017. 2017年度. [2P-0738]
  • 深山 俊治, 渡邉 裕介, 瀬谷 大貴, 井原 大, 荒井 勇二, 磯本 祥恵, 中川 修. 胎生期血管内皮細胞におけるHey1遺伝子の発現制御機構. 生命科学系学会合同年次大会. 2017. 2017年度. [4LT15-07(3P
  • 深山 俊治, 渡邉 裕介, 瀬谷 大貴, 井原 大, 荒井 勇二, 磯本 祥恵, 川村 晃久, 中川 修. Hey1転写調節因子の欠損マウスにおける胸部大血管形成異常と胎生期血管における遺伝子発現制御機構. 日本内分泌学会雑誌. 2017. 93. 4. 1380-1380
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Education (2)：
  • 1990 - 1994 Kyoto University Graduate School of Medicine
  • 1982 - 1988 Kyoto University Faculty of Medicine
Professional career (1)：
  • M.D., Ph.D. (Kyoto University)
Work history (9)：
  • 2023 - 現在 National Cerebral and Cardiovascular Center Research Institute Department of Genomic Medicine
  • 2014 - 2023 National Cerebral and Cardiovascular Center Research Institute, Department of Molecular Physiology Director
  • 2008 - 2014 Nara Medical University Advanced Medical Research Center Professor
  • 2005 - 2008 The University of Texas Southwestern Medical Center at Dallas Division of Cardiology, Department of Internal Medicine and Department of Molecular Biology Assistant Professor
  • 2001 - 2005 The University of Texas Southwestern Medical Center at Dallas Department of Molecular Biology Instructor/ Assistant Professor
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Awards (3)：
  • 2006 - March of Dimes Birth Defects Foundation Basil O’Connor Starter Scholar Research Award
  • 2003 - American Heart Association Louis N. and Arnold M. Katz Basic Research Prize for Young Investigators
  • 1995 - The Japanese Circulation Society Young Investigator Award
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