Rchr
J-GLOBAL ID：202001012207827457   Update date: Oct. 25, 2024

Takanezawa Yasukazu

タカネザワ ヤスカズ | Takanezawa Yasukazu
Affiliation and department：
Kitasato University School of Pharmacy, Faculty of Pharmacy・Department of Pharmaceutical Life Sciences, Laboratory of Public Health

About Kitasato University School of Pharmacy, Faculty of Pharmacy・Department of Pharmaceutical Life Sciences, Laboratory of Public Health


Job title： Associate Professor
Research field  (2)： Cell biology ,  Pharmaceuticals - health and biochemistry
Research keywords  (5)： オートファジー ,  有害金属 ,  メチル水銀 ,  環境汚染物質 ,  Toxicology
Research theme for competitive and other funds  (6)：
  • 2022 - 2025 The autophagy cargo receptor p62 and its mechanistic roles in methylmercury detoxication.
  • 2017 - 2020 Analysis of toxic heavy metals in neurodegenerative disorders and evaluation of derivatives of oleanoic acid as a therapeutic candidate
  • 2015 - 2018 Molecular breeding of Arabidopsis plants with cell-type specific promoters and a bacterial mercury transporter MerC
  • 2014 - 2016 Identification and characterization of methylmercy resposive proteins related to lipid composition
  • 2005 - 2007 New approaches to functional elucidation of unknown genes related to lipid metabolism : combination of mutational approaches using C. elegans and metabolite analyses using mass spectrometry
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Papers (51)：
  • Shimpei Uraguchi, Yuka Ohshiro, Kaede Abe, Yuta Tsuchiya, Ryosuke Nakamura, Yasukazu Takanezawa, Masako Kiyono. Root cell-type specific expressions of bacterial mercury transporter MerC and plant SNARE SYP121 fusion protein differentially affect cadmium accumulation patterns of Arabidopsis. SOIL SCIENCE AND PLANT NUTRITION. 2023
  • Yasukazu Takanezawa, Ryosuke Nakamura, Yuka Ohshiro, Shimpei Uraguchi, Masako Kiyono. Gadolinium-based contrast agents suppress adipocyte differentiation in 3T3-L1 cells. Toxicology letters. 2023. 383. 196-203
  • Yasukazu Takanezawa, Yui Kashiwano, Ryosuke Nakamura, Yuka Ohshiro, Shimpei Uraguchi, Masako Kiyono. Methylmercury drives lipid droplet formation and adipokine expression during the late stages of adipocyte differentiation in 3T3-L1 cells. Toxicology. 2023. 486. 153446-153446
  • Masako Kiyono, Yuka Ohshiro, Ryosuke Nakamura, Shimpei Uraguchi, Yasukazu Takanezawa. Molecular Toxicology of Methylmercury and Phytoremediation of Toxic Metals for Human Health. BPB Reports. 2023. 6. 4. 126-132
  • Yasukazu Takanezawa, Kazuma Sakai, Ryosuke Nakamura, Yuka Ohshiro, Shimpei Uraguchi, Masako Kiyono. Inhibition of p38 Mitogen-Activated Protein Kinases Attenuates Methylmercury Toxicity in SH-SY5Y Neuroblastoma Cells. Biological & pharmaceutical bulletin. 2023. 46. 9. 1203-1210
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MISC (35)：
  • 大橋悠暉, 高根沢康一, 酒井和真, 中村亮介, 大城有香, 浦口晋平, 清野正子. Autophgy response to toxic metal exposure in SH-SY5Y neuroblastoma cells. 衛生薬学・環境トキシコロジー講演要旨集. 2023. 2023
  • 高根沢康一, 柏野結, 中村亮介, 大城有香, 浦口晋平, 清野正子. Effect of autophagy on methylmercury-induced lipid droplet formation and adipokine expression in 3T3-L1 cells. Journal of Toxicological Sciences. 2023. 48. Supplement (CD-ROM)
  • 佐藤正和, 浦口晋平, 萬代麻衣, 大城有香, 中村亮介, 高根沢康一, 清野正子. 亜ヒ酸とカドミウム毒性に対するシロイヌナズナ根端分裂組織の応答の特異性. 日本土壌肥料学会講演要旨集(Web). 2023. 69
  • 浦口晋平, 山村有加, 菅谷翔, 佐藤正和, 大城有香, 中村亮介, 高根沢康一, 清野正子. 根端分裂組織のカドミウム・亜ヒ酸応答におけるNAC型転写因子ANAC044とANAC085の機能分化の可能性. 日本土壌肥料学会講演要旨集(Web). 2023. 69
  • 土屋佑太, 浦口晋平, 月岡輝璃, 西田翔, 大城有香, 中村亮介, 高根沢康一, 清野正子. 微生物由来の金属輸送体MerC多重発現シロイヌナズナの確立の試み. 日本土壌肥料学会講演要旨集(Web). 2023. 69
ｍore...
Lectures and oral presentations  (84)：
  • オートファジーレセプターp62欠損マウスのメチル水銀感受性の解析
    (メタルバイオサイエンス研究会 2024 2024)
  • 水銀化合物輸送における水銀トランスポーターMerCのシステイン残基の役割
    (フォーラム2024衛生薬学・環境トキシコロジー 2024)
  • Conversion of methylmercury into inorganic mercury via organomercurial lyase (MerB) activates autophagy and aggresome formation
    (2024)
  • Therapeutic effect of onji extract on methylmercury toxicity in mice
    (2024)
  • Functional role of autophagic receptors, p62 and NBR1, on MeHg cytotoxicity
    (2024)
ｍore...
Education (6)：
  • 2002 - 現在 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 1999 - 現在 北里大学大学院 修士(薬学)
  • 1997 - 現在 Kitasato University
  • 1999 - 2002 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 1997 - 1999 Kitasato University Graduate School of Pharmaceutical Sciences
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Professional career (1)：
  • Ph.D (The University of Tokyo)
Work history (6)：
  • 2019/04 - 現在 Kitasato University School of Pharmaceutical Sciences
  • 2015/04 - 2019/03 Kitasato University School of Pharmaceutical Sciences
  • 2014/09 - 2015/03 Kitasato University School of Pharmaceutical Sciences
  • 2014/04 - 2014/08 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 2003/02 - 2007/03 The University of Tokyo Graduate School of Pharmaceutical Sciences
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Association Membership(s) (3)：
日本生化学会 ,  日本毒性学会 ,  日本薬学会
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