Otani Takahito

オオタニタカヒト | Otani Takahito

Affiliation and department：
Job title： Associate professor
Homepage URL (1)： https://d.fdcnet.ac.jp/info/teacher/teacher_info_otani

Research field (3)： Nutrition and health science , Oral medicine , Metabolism and endocrinology

Research keywords (7)： Signaling pathway , Lipid metabolism , Glucose metabolism , Adipocyte , Osteocalcin , Epigenome , Cell death

Research theme for competitive and other funds (8)：

2024 - 2027 骨タンパクによる脂肪細胞の細胞外環境応答の変化~インスリン感受性亢進機序の解明~
2022 - 2025 Study of the role of desmosome cadherin in cell motility and lymph node metastasis
2022 - 2024 The role of osteocalcin in adipose tissue homeostasis
2018 - 2021 Elucidation of the mechanism of cell death of adipocytes induced by osteocalcin
2018 - 2019 オステオカルシンによるサルコペニア肥満回避機構の解明

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Papers (15)：

Takahito Otani, Akiko Mizokami, Hiroshi Takeuchi, Tetsuichiro Inai, Masato Hirata. The role of adhesion molecules in osteocalcin-induced effects on glucose and lipid metabolism in adipocytes. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2024. 1871. 4. 119701-119701
Shuhei Ogawa, Takashi Ishii, Takahito Otani, Yuko Inai, Takashi Matsuura, Tetsuichiro Inai. JNK inhibition enhances cell-cell adhesion impaired by desmoglein 3 gene disruption in keratinocytes. Histochemistry and cell biology. 2024
Mineyuki Mizuguchi, Takeshi Yokoyama, Takahito Otani, Shiori Kuribara, Yuko Nabeshima, Takayuki Obita, Masato Hirata, Keiichi Kawano. Structural and mutational analyses of decarboxylated osteocalcin provide insight into its adiponectin-inducing activity. FEBS Letters. 2023. 597. 11. 1479-1488
Shoko Ishikawa, Misaki Nikaido, Takahito Otani, Kayoko Ogata, Hiroshi Iida, Yuko Inai, Sachio Tamaoki, Tetsuichiro Inai. Inhibition of retinoid X receptor improved the morphology, localization of desmosomal proteins and paracellular permeability in three-dimensional cultures of mouse keratinocytes. Microscopy (Oxford, England). 2022. 71. 3. 152-160
Satoru Mukai, Akiko Mizokami, Takahito Otani, Tomomi Sano, Miho Matsuda, Sakura Chishaki, Jing Gao, Tomoyo Kawakubo-Yasukochi, Ronghao Tang, Takashi Kanematsu, et al. Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis. The Journal of biological chemistry. 2021. 100274-100274

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MISC (21)：

小川修平, 大谷崇仁, 緒方佳代子, 稲井哲一朗. Analysis of the effects of desmoglein 3 deficiency on keratinocytes. Journal of Oral Biosciences Supplement (Web). 2022. 2022
大谷崇仁, 松田美穂, 溝上顕子, 北河憲雄, 自見英治郎, 自見英治郎, 稲井哲一朗, 平田雅人. (Symposiast) Amelioration of cell number and metabolic features of adipocytes by osteocalcin. Journal of Oral Biosciences Supplement (Web). 2020. 2020
Takahito Otani, Miho Matsuda, Akiko Mizokami, Norio Kitagawa, Hiroshi Takeuchi, Eijiro Jimi, Tetsuichiro Inai, Masato Hirata. (Symposiast) Necroptosis of Adipocytes Induced by Osteocalcin. Kyudai Oral Bioscience & OBT Research Center Joint International Symposium 2019. 2019
大谷崇仁, 松田美穂, 溝上顕子, 北河憲雄, 自見英治郎, 自見英治郎, 稲井哲一朗, 平田雅人. (シンポジスト) 脂肪細胞を細胞死へと導く骨基質タンパクOsteocalcin. Journal of Oral Biosciences Supplement (Web). 2019. 2019
Masato Hirata, Takahito Otani, Akiko Mizokami, Norio Kitagawa, Eijiro Jimi, Tetsuichiro Inai. Programmed Necrosis of Adipocytes Induced by High-dose Osteocalcin. 2018

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Education (2)：

Professional career (1)：

Work history (5)：

Awards (5)：

Association Membership(s) (4)：

日本歯科医学教育学会 , The Molecular Biology Society of Japan , The Japanese Association of Anatomists , Japanese Association for Oral Biology

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