Rchr
J-GLOBAL ID:202001015186630410   Update date: May. 31, 2022

Koike (Ouchi) Rie

コイケ リエ | Koike (Ouchi) Rie
Affiliation and department:
Other affiliations (1):
  • National Museum of Emerging Science and Innovation(MIRAIKAN)  Human Organoid Project 
Research field  (2): Cell biology ,  Molecular biology
Research keywords  (3): 非アルコール性脂肪性肝炎(NASH) ,  Autonomic nerves ,  Organoid
Research theme for competitive and other funds  (2):
  • 2021 - 2023 ヒト肝臓オルガノイドを用いた肝内自律神経によるNASHの病態進展制御機構の解明
  • 2014 - 2016 グリオブラストーマ幹細胞におけるテロメア長維持機構の解明
Papers (10):
  • Hiroyuki Koike, Kentaro Iwasawa, Rie Ouchi, Mari Maezawa, Masaki Kimura, Asuka Kodaka, Shozo Nishii, Wendy L Thompson, Takanori Takebe. Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells. Nature protocols. 2021
  • Tadahiro Shinozawa, Masaki Kimura, Yuqi Cai, Norikazu Saiki, Yosuke Yoneyama, Rie Ouchi, Hiroyuki Koike, Mari Maezawa, Ran-Ran Zhang, Andrew Dunn, et al. High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell-Derived Organoids. Gastroenterology. 2020
  • Naritaka Kobayashi, Shodai Togo, Takahisa Matsuzaki, Kaede Hashiseko, Ryuzo Kawamura, Masami Suganuma, Seiichiro Nakabayashi, Yosuke Yoneyama, Rie Ouchi, Takanori Takebe, et al. Stiffness distribution analysis in indentation depth direction reveals clear mechanical features of cells and organoids by using AFM. Applied Physics Express. 2020. 13. 9
  • Hiroyuki Koike, Kentaro Iwasawa, Rie Ouchi, Mari Maezawa, Kirsten Giesbrecht, Norikazu Saiki, Autumn Ferguson, Masaki Kimura, Wendy L Thompson, James M Wells, et al. Modelling human hepato-biliary-pancreatic organogenesis from the foregut-midgut boundary. Nature. 2019. 574. 7776. 112-116
  • Rie Ouchi, Shodai Togo, Masaki Kimura, Tadahiro Shinozawa, Masaru Koido, Hiroyuki Koike, Wendy Thompson, Rebekah A Karns, Christopher N Mayhew, Patrick S McGrath, et al. Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids. Cell metabolism. 2019. 30. 2. 374-384
more...
MISC (7):
  • 小池梨江. 多細胞系からなるヒト肝臓オルガノイドを用いたNAFLDの病態モデルの再現. 日本再生医療学会総会(Web). 2021. 20th
  • 大内 梨江, 武部 貴則. 【iPS再生医療の最前線】iPS細胞を用いたヒューマン・オルガノイド研究. BIO Clinica. 2019. 34. 13. 1306-1310
  • 藤友崇, 大井潤, 大内梨江, 米山鷹介, 吉澤絵美, 武部貴則, 武部貴則, 武部貴則. 「MYCODE Research」を活用したゲノム層別化iPS細胞研究. 日本再生医療学会総会(Web). 2019. 18th
  • 東郷祥大, 東郷祥大, 大内梨江, 篠澤忠紘, 小池博之, 吉川洋史, 武部貴則. ヒトiPS細胞由来肝臓オルガノイドを用いた炎症・線維化モデルの構築. 応用物理学会春季学術講演会講演予稿集(CD-ROM). 2018. 65th
  • 東郷祥大, 東郷祥大, 大内梨江, 篠澤忠紘, 小池博之, 吉川洋史, 武部貴則. ヒトiPS細胞由来肝臓オルガノイドを用いた炎症・線維化モデルの構築. 応用物理学会秋季学術講演会講演予稿集(CD-ROM). 2017. 78th
more...
Patents (1):
Books (1):
  • オルガノイド実験スタンダード : 決定版 : 開発者直伝!珠玉のプロトコール集
    羊土社 2019 ISBN:9784758122399
Lectures and oral presentations  (23):
  • Modeling Steatohepatitis with Multicellular Organoids from Human Induced Pluripotent Stem Cells
    (The International Society for Stem Cell Research (ISSCR) 2021 2021)
  • Modeling NAFLD with Multicellular Liver Organoid from Human Pluripotent Stem Cell
    (The 20th Congress of the Japanese Society for Regenerative Medicine 2021)
  • 炎症・線維化病態を再現するヒューマンオルガノイド技術の開発の成功
    (United Japanese Researchers Around the World Paper Award 2020 2020)
  • 「MYCODE Research」を活用したゲノム層別化iPS細胞研究
    (The 18th Congress of the Japanese Society for Regenerative Medicine 2019)
  • ヒトiPS細胞由来肝臓オルガノイドを用いた炎症・線維化モデルの構築
    (第65回応用物理学会春季学術講演会 2018)
more...
Education (4):
  • 2013 - 2016 The University of Tokyo Department of Computational Biology and Medical Sciences
  • 2011 - 2013 Yokohama City University
  • 2009 - 2011 Tamagawa University Department of Life Science
  • 2006 - 2008 College of the Desert
Work history (4):
  • 2018/06 - 現在 Tokyo Medical and Dental University Institute of Research, Division of Advanced Multidisciplinary Research, Organ and Tissue Neogenesis Consortium
  • 2016/06 - 2018/06 Cincinnati Children’s Hospital Medical Center Division of Developmental Biology, Division of Gastroenterology, Hepatology and Nutrition Research Fellow
  • 2016/04 - 2016/06 Japanese Foundation for Cancer Research The Cancer Chemotherapy Center, Molecular Biotherapy
  • 2014/04 - 2016/03 Japan Society for the Promotion of Science Research Fellow
Awards (16):
  • 2021/10 - Astellas Foundation for Research on Metabolic Disorders Takenaka Incentive Award
  • 2020/10 - United Japanese researchers Around the world (UJA) United Japanese researchers Around the world (UJA) Outstanding Paper Award Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids
  • 2020 - Corning 2020 Corning Life Science Ambassador
  • 2019/09 - Tokyo Medical and Dental University The Third Generation Researcher Training Unit
  • 2017/02 - Cincinnati Children's Hospital Medical Center Third Place at the Poster Presentation in Digestive Health Center Annual Scientific Retreat,
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