KANOH HIROTAKA

Affiliation and department：
Job title：助教
Research theme for competitive and other funds (7)：

2021 - 2024 Development of a system to analyze the intracellular dynamics of TLR4 for the discovery of novel vaccine adjuvants
2021 - 2024 ガングリオシドのアシル鎖構造を介した自然免疫制御メカニズムの解明
2021 - 2024 生体膜糖脂質による共受容体制御を介した新たなレプチン受容体シグナル制御機構の解明
2020 - 2024 New paradigm for the regulation of chronic inflammation by glycosphingolipids
2019 - 2022 Elucidation of TLR activation mechanisms mediated by gangliosides and its acyl-chain structures

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Papers (33)：

Inamori Kei-ichiro, Kanoh Hirotaka, Nitta Takahiro, Inokuchi Jin-ichi. Regulation of glycosphingolipid functions by structural diversity of ceramide moiety. 2024. 96. 4. 448-456
Ayane Miura, Yoshiyuki Manabe, Kenichi G. N. Suzuki, Hiroki Shomura, Soichiro Okamura, Asuka Shirakawa, Kumpei Yano, Shuto Miyake, Koki Mayusumi, Chun-Cheng Lin, et al. De Novo Glycan Display on Cell Surfaces Using HaloTag: Visualizing the Effect of the Galectin Lattice on the Lateral Diffusion and Extracellular Vesicle Loading of Glycosylated Membrane Proteins. Journal of the American Chemical Society. 2024
Go Anan, Takahiro Nitta, Hirotaka Kanoh, Makoto Sato, Jin-Ichi Inokuchi. Perioperative changes in ganglioside monosialodihexosylganglioside (GM3) molecular species for benign prostatic hyperplasia: a preliminary report. Translational andrology and urology. 2024. 13. 1. 104-108
Jin-Ichi Inokuchi, Shinji Go, Akemi Suzuki, Osamu Nakagawasai, Takayo Odaira-Satoh, Lucas Veillon, Takahiro Nitta, Paul McJarrow, Hirotaka Kanoh, Kei-Ichiro Inamori, et al. Dietary gangliosides rescue GM3 synthase deficiency outcomes in mice accompanied by neurogenesis in the hippocampus. Frontiers in neuroscience. 2024. 18. 1387221-1387221
Kazuya Takeda, Tomonori Kaifu, Ryunosuke Michihata, Naotaka Kinugawa, Atushi Fujioka, Ayaka Tateno, Kaoru Toshima, Hirotaka Kanoh, Kei-Ichiro Inamori, Keiju Kamijo, et al. Chronic encephalomyelitis virus exhibits cellular tropism and evades pDCs by binding to sialylated integrins as the cell surface receptors. European journal of immunology. 2023. e2350452

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MISC (16)：

井ノ口仁一, 狩野裕考, 新田昂大, 稲森啓一郎, 石川潮, 樺山一哉, 黄栩昊, 下山敦史, 深瀬浩一. GM3分子種によるTLR4及びCaspase4/11の活性化制御. 日本生化学会大会(Web). 2023. 96th
狩野裕考, 新田昂大, 井ノ口仁一. GM3 ganglioside-mediated control of TLR4 signaling. 月刊メディカル・サイエンス・ダイジェスト. 2022. 48. 1
新田昂大, 狩野裕考, 稲森啓一郎, 鈴木明身, 井ノ口仁一. 1型と2型糖尿病性腎症における腎スフィンゴ糖脂質発現変化の比較. 日本生化学会大会(Web). 2021. 94th
狩野裕考, 新田昂大, 井ノ口仁一. ガングリオシドGM3分子種による生活習慣病・慢性炎症性疾患等の新規診断・治療法の開発. 臨床病理. 2020. 68. 1
Kanoh Hirotaka, Nitta Takahiro, Fujii Mayu, Kabayama Kazuya, Shimoyama Atsushi, Fukase Koichi, Sonnino Sandro, Suzuki Akemi, Inokuchi Jin-ichi. Acyl-chain structures of gangliosides GM3 species regulate TLR4 signaling. Endotoxin and Innate Immunity. 2019. 22. 0. 1-7

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