Izu Yayoi

イズヤヨイ | Izu Yayoi

Affiliation and department：
Job title：准教授

Research field (5)： Orthopedics , Sports science , Cell biology , Laboratory animal science , Morphology, anatomy

Research keywords (1)： Extracellular Matrix, Collagens, tendons and Ligaments. Bone

Research theme for competitive and other funds (15)：

2023 - 2027 Elucidation of early bone tissue architecture by in vivo volumetric image analysis-from both sides of cells and bone matrix
2022 - 2027 Elucidation of regulatory mechanisms of tendon homeostasis via tenocyte network.
2021 - 2023 FACITタイプ12型コラーゲンによる運動器制御機構の解明
2019 - 2022 The role of Collagen 6 in knee anterior cruciate ligament
2018 - 2021 Elucidation of collagen XII regulatory role in osteoarthritis

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Papers (40)：

Kiyotaka Arai, Fumiyo Saito, Masashi Miyazaki, Haruto Kushige, Yayoi Izu, Noritaka Maeta, Kazuaki Yamazoe. Small Molecules Temporarily Induce Neuronal Features in Adult Canine Dermal Fibroblasts. International Journal of Molecular Sciences. 2023. 24. 21. 15804-15804
Shuhei Kajikawa, Yoichi Ezura, Yayoi Izu, Kazuhisa Nakashima, Masaki Noda, Akira Nifuji. Profilin-1 negatively controls osteoclast migration by suppressing the protrusive structures based on branched actin filaments. Journal of Bone and Mineral Metabolism. 2022
Shin Fukusato, Masashi Nagao, Kei Fujihara, Taiju Yoneda, Kiyotaka Arai, Manuel Koch, Kazuo Kaneko, Muneaki Ishijima, Yayoi Izu. Collagen XII Deficiency Increases the Risk of Anterior Cruciate Ligament Injury in Mice. Journal of clinical medicine. 2021. 10. 18
Yayoi Izu, Sheila M. Adams, Brianne K. Connizzo, David P. Beason, Louis J. Soslowsky, Manuel Koch, David E. Birk. Collagen XII mediated cellular and extracellular mechanisms regulate establishment of tendon structure and function. Matrix Biology. 2020
Jumpei Shirakawa, Shuhei Kajikawa, Ralph T Böttcher, Mercedes Costell, Yayoi Izu, Tadayoshi Hayata, Masaki Noda, Yoichi Ezura. Profilin 1 Negatively Regulates Osteoclast Migration in Postnatal Skeletal Growth, Remodeling, and Homeostasis in Mice. JBMR plus. 2019. 3. 6. e10130

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MISC (8)：

R. Hanyu, Y. Saita, J. Nagata, Y. Izu, H. Hemmi, S. Takade, Y. Ezura, H. Kurosawa, M. Noda. Aging Dependent and Independent Effects of b2 Adrenergic Receptor Signaling on Bone Formation Induced by Intermittent PTH Treatment Female Mice. JOURNAL OF BONE AND MINERAL RESEARCH. 2008. 23. S204-S204
T. Nakamoto, F. Mizoguchi, Y. Izu, T. Hayata, Y. Ezura, D. Mathis, C. Benoist, N. Miyasaka, M. Noda. Deficiency of the Nucleocytoplasmic Shuttling Protein CIZ Suppresses K/BxN Serum-Induced Model of Rheumatoid Arthritis. JOURNAL OF BONE AND MINERAL RESEARCH. 2008. 23. S487-S487
M. Nagao, Y. Saita, J. Nagata, Y. Izu, T. Hayata, H. Hemmi, Y. Ezura, H. Kurosawa, M. Noda. Role of OPN in Beta-adrenergic Signaling Induced Bone Loss in vivo. JOURNAL OF BONE AND MINERAL RESEARCH. 2008. 23. S416-S416
K. Miyai, Y. Izu, H. Hemmi, T. Hayata, T. Nakamoto, Y. Ezura, T. Pawson, S. Mizutani, M. Noda. Deficiency of NCK1, an Actin Cytoskeletal Modulator with SH2/SH3 Motifs, Induces Bone Loss via Suppression of Bone Formation and Induction of Biochemical High Bone Turnover State. JOURNAL OF BONE AND MINERAL RESEARCH. 2008. 23. S380-S380
R. Hanyu, Y. Saita, J. Nagata, Y. Izu, T. Hayata, H. Hemmi, S. Takeda, Y. Ezura, K. Nakashima, H. Kurosawa, et al. beta 2 adrenergic receptor deficiency enhances bone mass in by antagonizing against aging-induced bone loss and blunts anabolic effects of PTH on osteoblasts. JOURNAL OF BONE AND MINERAL RESEARCH. 2007. 22. S88-S88

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Education (2)：

Work history (7)：

2018 - 現在 Okayama University of Science Department of Veterinary Medicine Associate Professor
2016 - 2018 Chiba Institute of Science Faculty of Risk and Crisis Management, Department of Risk and Crisis Management for Animals Lecturer
2014 - 2016 Tokyo Medical and Dental University Medical Research Institute Assistant professor
2013 - 2014 University of South Florida College of Medicine Research Associate
2010 - 2013 Pennstate University college of Medicine postdoctoral fellow

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Awards (9)：

2021 - 日本骨代謝学会日本骨代謝学会フロンティア研究者助成 FACITタイプ12型コラーゲンによる運動器制御機構の解明
2021 - 森永奉仕会森永賞小児希少疾患であるミオパチー型エーラス・ダンロス症候群のエネルギー代謝機構をターゲットとした治療法の開発
2018 - 鈴木謙三記念医科学応用研究財団生活習慣病における医学、薬学の萌芽的研究サルコペニアの病態マーカーの同定
2017 - 内藤記念科学振興財団内藤記念科学奨励賞受賞ロコモティブシンドロームにおける筋肉・腱・骨ネットワークの制御
2016 - 34th the Japanese Society for Bone and Mineral Research poster award Collagen XII is associated with cell-cell communication in tendon.

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