Rchr
J-GLOBAL ID：202001017581559581
Update date: Sep. 29, 2024
wakita masahiro
ワキタ マサヒロ | wakita masahiro
Affiliation and department：
Research theme for competitive and other funds (3)：
- 2022 - 2025 加齢性疾患克服に向けた漸進型の老化細胞除去療法の確立
- 2020 - 2022 Understanding the interrelationship between senescent cells and age-related diseases and the elucidation of the mechanisms for the killing of senescent cells by senolytic drugs
- 2018 - 2020 Approach toward age-related diseases with the use of a new senolytic drugs
Papers (6)：
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Shunya Tsuji, Shohei Minami, Rina Hashimoto, Yusuke Konishi, Tatsuya Suzuki, Tamae Kondo, Miwa Sasai, Shiho Torii, Chikako Ono, Shintaro Shichinohe, et al. SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response. Nature aging. 2022. 2. 2. 115-124
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Shintaro Okumura, Yusuke Konishi, Megumi Narukawa, Yuki Sugiura, Shin Yoshimoto, Yuriko Arai, Shintaro Sato, Yasuo Yoshida, Shunya Tsuji, Ken Uemura, et al. Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion. Nature communications. 2021. 12. 1. 5674-5674
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Masahiro Wakita, Akiko Takahashi, Osamu Sano, Tze Mun Loo, Yoshinori Imai, Megumi Narukawa, Hidehisa Iwata, Tatsuyuki Matsudaira, Shimpei Kawamoto, Naoko Ohtani, et al. A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells. Nature communications. 2020. 11. 1. 1935-1935
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Akiko Takahashi, Tze Mun Loo, Ryo Okada, Fumitaka Kamachi, Yoshihiro Watanabe, Masahiro Wakita, Sugiko Watanabe, Shimpei Kawamoto, Kenichi Miyata, Glen N Barber, et al. Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells. Nature communications. 2018. 9. 1. 1249-1249
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Masahiro Wakita, Hironori Edamatsu, Mingzhen Li, Aki Emi, Sohei Kitazawa, Tohru Kataoka. Phospholipase Cε Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells. The Journal of biological chemistry. 2016. 291. 24. 12586-600
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MISC (15)：
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脇田 将裕, 伊藤 甲雄, 原 英二. 【炎症老化 Inflammaging】細胞老化とSASP 生理的役割と治療標的としての可能性. 実験医学. 2023. 41. 19. 3083-3089
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脇田 将裕, 原 英二. 【セノリティクス】BETファミリー蛋白質阻害剤による老化細胞除去がもたらすがん治療の可能性. 細胞. 2023. 55. 2. 80-83
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脇田 将裕, 原 英二. 【老化はなぜ進むのか Why do we age?】細胞老化の生理機能とその旋御. BIO Clinica. 2022. 37. 14. 1266-1270
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脇田 将裕, 原 英二. 【老化細胞を標的としたSenolyticsへの挑戦 加齢性疾患を引き起こすメカニズムの理解と治療への展開】細胞老化現象に着目した新たながん治療戦略. 実験医学. 2022. 40. 3. 371-376
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脇田将裕, 原英二. The Potential of Novel Senotherapy for Cancer Treatment. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
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Patents (1)：
Books (2)：
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医薬品モダリティにおける 創薬技術開発と展望
2024 ISBN:9784865022711
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生物の寿命延長 : 老化・長寿命の基盤研究最前線
エヌ・ティー・エス 2022 ISBN:9784860437732
Work history (1)：
- 2024/09 - 現在 Osaka University Research Institute for Microbial Diseases
Awards (1)：
- 2020/02 - Best Presentation Award High-throughput screening of senolysis drug uncovers cellular vulnerability of senescent cells
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