OHTA YASUTAKA

オオタヤスタカ | OHTA YASUTAKA

Affiliation and department：
Job title：教授

Research field (1)： Cell biology

Research keywords (7)： Cell-cell Interaction , small GTPase , Cancer Cell Invasion , Cell Migration , Signal Transduction , Cytoskeleton , Cell Biology

Research theme for competitive and other funds (10)：

2018 - 2022 Actin cytoskeletal regulation of process formation in kidney podocytes.
2017 - 2020 Functional analysis of FilGAP in epithelial tubulogenesisi
2010 - 2012 Studies on the role of FiliGAP (RacGAP) in mesenchymal and amoeboid cell migration.
2007 - 2009 Studies on the role of FiliGAP (RacGAP) in cell migration, adhesion, and polarization.
1992 - 1993 Molecular pharmacological studies on the expression of synaptic plasticity

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Papers (41)：

Koji Saito, Seiji Yokawa, Hidetake Kurihara, Eishin Yaoita, Sari Mizuta, Kanae Tada, Moemi Oda, Hiroyasu Hatakeyama, Yasutaka Ohta. FilGAP controls cell-extracellular matrix adhesion and process formation of kidney podocytes. The FASEB Journal. 2024. 38. 5
Koji Tsutsumi, Yasutaka Ohta. RSK/GSK3-mediated phosphorylation of FilGAP regulates chemotactic cancer invasion. PNAS Nexus. 2024
Koji Tsutsumi, Ayumi Nohara, Taiki Tanaka, Moe Murano, Yurina Miyagaki, Yasutaka Ohta. FilGAP regulates tumor growth in Glioma through the regulation of mTORC1 and mTORC2. Scientific reports. 2023. 13. 1. 20956-20956
Koji Saito, Sakino Ozawa, Yosuke Chiba, Ruri Takahashi, Ryoya Ogomori, Kojiro Mukai, Tomohiko Taguchi, Hiroyasu Hatakeyama, Yasutaka Ohta. FilGAP, a GAP for Rac1, down-regulates invadopodia formation in breast cancer cells. Cell structure and function. 2023. 48. 2. 161-174
Mamiko Mori, Koji Saito, Ayano Sekine, Rio Hasebe, Yasutaka Ohta. Endosomal Localization of RacGAP Protein ARHGAP22 Regulates its GAP Activity in Human Melanoma Cells. Anticancer research. 2022. 42. 12. 5763-5771

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MISC (4)：

堤弘次, 長谷川稜, 戸田あかり, 堀羽衣音, 渡邊利雄, 太田安隆. Arf1 regulates membrane blebbing. 日本細胞生物学会大会(Web). 2021. 73rd
Control of switching between migration modes in cancer invasion. 2017. 89. 1. 90-93
堤弘次, 中村遥, 北川裕介, 鈴木柚里奈, 柴垣芳夫, 服部成介, 太田安隆. ArfGAP因子AGAP1はArfの不活性化およびRacGAP因子FilGAPとの結合を介して細胞形態を制御する. 日本生化学会大会(Web). 2017. 90th
宮崎碧, 堤弘次, 柴垣芳夫, 服部成介, 太田安隆. 微小管モータータンパク質Kinesin-5は創傷治癒において細胞運動に抑制的に働く. 日本生化学会大会(Web). 2017. 90th

Books (1)：

ビギナーズ生物学 = Biology for beginners
化学同人 2017 ISBN:9784759819373

Education (2)：

1982 - 1987 Graduate School of Science University of Tokyo
1978 - 1982 University of Tokyo Faculty of Science

Work history (4)：

2007/04 - 現在北里大学理学部教授
1999/04 - 2007/03 Harvard University assistant professor
1993/04 - 1999/03 Harvard University Instructor
1987/04 - 1993/03 熊本大学医学部助手

Awards (1)：

1900 - 加藤記念研究奨励賞

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