Research theme for competitive and other funds (8):
2024 - 2027 エレクトロスピニング法で調製した後眼部疾患用眼瞼貼付製剤の開発
2024 - 2027 関節軟骨基質の電荷特性を応用した新規変形性関節症治療薬開発の基盤研究
2023 - 2025 Naked mRNA吸入粉末剤開発のための実証実験
2023 - 2024 エレクトロスピニングファイバーの吸入粉末剤への応用
2022 - 2024 Development of porous dry inhalation powder using electrospun nanofiber mat.
2022 - 2023 Development of porous dry inhalation powder using electrospun nanofiber mat.
2020 - 2022 Development of ophthalmic gene therapy by direct application of naked pDNA powder to the palatal conjunctiva.
2020 - 2021 エレクトロスピニング多孔性ファイバーを用いた新規吸入粉末剤調製法の確立
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Papers (16):
Koki Ogawa, Otowa Aikawa, Tatsuaki Tagami, Takaaki Ito, Kohei Tahara, Shigeru Kawakami, Tetsuya Ozeki. Stable and inhalable powder formulation of mRNA-LNPs using pH-modified spray-freeze drying. International Journal of Pharmaceutics. 2024. 124632-124632
Ayaka Miki, Kouji Hara, Takato Shibata, Toshifumi Morioka, Ayaka Kobayashi, Nobuyoshi Yoshimura, Eriko Yamazoe, Takaaki Ito, Kohei Tahara. Development of a solid dispersion system for polyvinyl alcohol nanofibers embedded with silicon dioxide particles via emulsion electrospinning for improved solubility of poorly water-soluble drugs. Journal of Drug Delivery Science and Technology. 2024. 99. 105915-105915
Takaaki Ito, Shintaro Tamashiro, Hiroki Okuda, Eriko Yamazoe, Kohei Tahara. Cryomilled electrospun nanofiber mats containing d-mannitol exhibit suitable for aerosol delivery of proteins. International Journal of Pharmaceutics. 2024. 661. 124425-124425
Miyu Kanamori, Kouji Hara, Eriko Yamazoe, Takaaki Ito, Kohei Tahara. Development of Polyvinyl Alcohol (PVA) Nanofibers Containing Cationic Lipid/siRNA Complexes via Electrospinning: The Impact of PVA Characterization. Nanomaterials. 2024. 14. 13. 1083-1083
Riho Ogawa, Kouji Hara, Ayaka Kobayashi, Nobuyoshi Yoshimura, Yutaka Taniguchi, Eriko Yamazoe, Takaaki Ito, Kohei Tahara. Controlled Release of Lysozyme Using Polyvinyl Alcohol-Based Polymeric Nanofibers Generated by Electrospinning. Chemical and Pharmaceutical Bulletin. 2024. 72. 3. 324-329