Rchr
J-GLOBAL ID:202001020764885314   Update date: Sep. 01, 2020

Michiue Hiroyuki

ミチウエ ヒロユキ | Michiue Hiroyuki
Affiliation and department:
Job title: 准教授
Research field  (1): Neurosurgery
Research keywords  (12): drug delivery system ,  blood brain barrier ,  actin polymerization ,  cancer stem cell ,  brain tumor stem cell ,  cell invasion ,  cell penetrating peptide ,  peptide discovery ,  drug repositioning ,  glioblastoma ,  malignant brain tumor ,  BNCT Boron Neutron Capture Therapy
Research theme for competitive and other funds  (17):
  • 2020 - 2023 BNCT併用メラノーマ複合免疫療法へ向けた前臨床探索研究と新規ホウ素薬剤開発
  • 2019 - 2022 難治性消化器がんを標的としたホウ素中性子捕捉療法の開発と効果予測マーカーの探索
  • 2018 - 2021 細胞内局在を標的とした新規ホウ素薬剤の開発とBNCT
  • 2018 - 2021 ドラッグリポジショニングを用いた非VEGF経路に対する新規抗血管新生薬開発
  • 2017 - 2020 Neurogenesis and depression in the central nervous system disorders
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Papers (54):
  • Yoshiyuki Hakata, Hiroyuki Michiue, Takashi Ohtsuki, Masaaki Miyazawa, Mizuki Kitamatsu. A leucine zipper-based peptide hybrid delivers functional Nanog protein inside the cell nucleus. Bioorganic & medicinal chemistry letters. 2019. 29. 7. 878-881
  • Masahiro Yamagami, Tomoyuki Tajima, Kango Ishimoto, Hideaki Miyake, Hiroyuki Michiue, Yutaka Takaguchi. Physical modification of carbon nanotubes with a dendrimer bearing terminal mercaptoundecahydrododecaborates (Na2B12H11S). HETEROATOM CHEMISTRY. 2018. 29. 5-6
  • Hiroyuki Shiba, Koji Takeuchi, Ryo Hiramatsu, Motomasa Furuse, Naosuke Nonoguchi, Shinji Kawabata, Toshihiko Kuroiwa, Natsuko Kondo, Yoshinori Sakurai, Minoru Suzuki, et al. Boron Neutron Capture Therapy Combined with Early Successive Bevacizumab Treatments for Recurrent Malignant Gliomas - A Pilot Study. NEUROLOGIA MEDICO-CHIRURGICA. 2018. 58. 12. 487-494
  • Hein Min Latt, Hiroaki Matsushita, Miku Morino, Yuuri Koga, Hiroyuki Michiue, Teiichi Nishiki, Kazuhito Tomizawa, Hideki Matsui. Oxytocin Inhibits Corticosterone-induced Apoptosis in Primary Hippocampal Neurons. Neuroscience. 2018. 379. 383-389
  • Y Otani, T Ichikawa, K Kurozumi, S Inoue, J Ishida, T Oka, T Shimizu, Y Tomita, Y Hattori, A Uneda, et al. Fibroblast growth factor 13 regulates glioma cell invasion and is important for bevacizumab-induced glioma invasion. Oncogene. 2018. 37. 6. 777-786
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Lectures and oral presentations  (25):
  • "Current status of boron drug development-From basic research to clinical research-
    (2020)
  • Translational research in hair generation from lab to life
    (National Symposium and Workshop in Anti-Aging Medicine committee 2020)
  • The role of calcineurin in controlling cell function in hair generation
    (National Symposium and Workshop in Anti-Aging Medicine 2020)
  • Efforts to formulate new boron drug formulations using peptide DDS
    (The 3rd Neutron Therapy Research Center Symposium 2019)
  • New boron(10B) drugs against GBM
    (SickKids Hospital Reserch meeting organized by the Labatt Brain Tumor Research Centre 2019)
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Education (2):
  • 1999 - 2005 Okayama University doctor course
  • 1993 - 1999 Okayama University Faculty of Medicine
Work history (7):
  • 2017/04 - 現在 Okayama University Neutron Therapy Research Center Associate Professor
  • 2010/04 - 2017/03 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences Assistant Professor
  • 2007/11 - 2010/03 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences Assistant Professor
  • 2005/06 - 2007/10 University of California, San Diego School of medicine Research Associate
  • 2001/11 - 2002/10 Okayama University University Hospital Medical Doctor
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Committee career (1):
  • 2020/06 - 現在 Japanese Society of Neutron Capture Therapy member of committee
Awards (5):
  • 2015/05 - 15th International Congress of Radiation Research 15th International Congress of Radiation Research Excellent Poster Award The Development of BSH Fused Cell-penetrating Peptide towards Clinical Application
  • 2014/06 - Okayama Medical Association Yuuki Award in Okayama Medical Association The acceleration of boron neutron capture therapy using multi-linked mercaptoundecahydrododecaborate (BSH) fused cell-penetrating peptide.
  • 2010/11 - The Physiological Society of Japan Research Award in The Physiological Society of Japan in CHUGOKU Novel siRNA delivery system with protein transduction method
  • 2006/06 - Okayama Medical Association Yamada Prize in Okayama Medical Association
  • 2005/01 - The 3rd Campus Venture Grand Prix in CHUGOKU President's Award of the Economic Federation of CHUGOKU
Association Membership(s) (5):
The Japan Cancer Association ,  Japanese Society of Neutron Capture Therapy ,  The Japan Society for Neuro-Oncology ,  The Japan Stroke Society ,  The Japan Neurosurgical Society
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