Rchr
J-GLOBAL ID：202001021061597836   Update date: Jan. 30, 2024

KATAFUCHI Takeshi

カタフチ タケシ | KATAFUCHI Takeshi
Affiliation and department：
Nihon University School of Medicine Department of Medicine

About Nihon University School of Medicine Department of Medicine


Job title： Associate Professor
Research field  (1)： Medical biochemistry
Research keywords  (1)： biochemistry, molecular biology, endocrinology, pharmacology
Research theme for competitive and other funds  (7)：
  • 2022 - 2025 Identification of the transcription factor that reduce ileal Fgf15 expression level by the food intake after a long-term starvation
  • 2020 - 2022 Postprandial reduction of FGF15 expression after starvation in mouse ileum.
  • 1998 - 2002 Adrenomedullin, a new peptidergic factor regulating inflammation and proliferation
  • 2000 - 2001 ブタ腎臓上皮細胞の細胞内cAMP濃度を上昇させる新規生理活性ペプチドの解析
  • 1999 - 2000 Purification and structural determination of new vasoactive peptides and elucidation of their effects on the vascular wall cells
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Papers (29)：
  • Takeshi Katafuchi, Makoto Makishima. Molecular Basis of Bile Acid-FXR-FGF15/19 Signaling Axis. International Journal of Molecular Science. 2022. 23. 11. 6046
  • Katafuchi T, Holland WL, Kollipara RK, Kittler R, Mangelsdorf DJ, Kliewer SA. PPARγ-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice. Proc Natl Acad Sci U S A. 2018. 115. 48. 12102-12111
  • Slijepcevic D, Roscam Abbing RLP, Katafuchi T, Blank A, Donkers JM, van Hoppe, S, de Waart DR, Tolenaars D, van der Meer JHM, et al. Hepatic uptake of conjugated bile,acids is mediated by both sodium taurocholate cotransporting polypeptide and,organic anion transporting polypeptides and modulated by intestinal sensing of,plasma bile acid levels in mice. Hepatology. 2017. 66. 5. 1631-1643
  • Katafuchi T, Esterházy D, Lemoff A, Ding X, Sondhi V, Kliewer SA, Mirzaei H, Mangelsdorf DJ. Detection of FGF15 in plasma by stable isotope standards and,capture by anti-peptide antibodies and targeted mass spectrometry. Cell Metabolism. 2015. 21. 6. 898-904
  • Katafuchi T. Mutations in Tyr808 reveal a potential auto-inhibitory mechanism of guanylate cyclase-B regulation. Biosci Rep. 2013. 33. 3. e00039
ｍore...
MISC (10)：
  • Takeshi Katafuchi and Makoto Makishima. Fatty Acid Metabolism during Exercise. 日大医学雑誌. 2021. 80. 1. 15-19
  • Katafuchi T, Yasue H, Osaki T, Minamino N. Calcitonin receptor-stimulating peptide: Its evolutionary and functional relationship with calcitonin/calcitonin gene-related peptide based on gene structure. Peptides. 2009. 30. 9. 1753-1762
  • Rezaeian AH, Katafuchi T, Yoshizawa M, Hiraiwa N, Saito T, Nishibori M, Hamano K, Minamino N, Yasue H. Genomic organization, expression and evolution of porcine CRSP1, 2, and 3. Cytogenet Genome Res. 2008. 121. 1. 41-49
  • Osaki T, Katafuchi T, Minamino N. Genomic and expression analysis of canine calcitonin receptor-stimulating peptides and calcitonin/calcitonin gene-related peptide. J Biochem. 2008. 144. 48. 419-430
  • Notoya M, Arai R, Katafuchi T, Minamino N, Hagiwara H. A novel member of the calcitonin gene-related peptide family, calcitonin receptor-stimulating peptide, inhibits the formation and activity of osteoclasts. Eur J Pharmacol. 2007. 560. 2-3. 234-239
ｍore...
Patents (1)：
  • カルシトニン受容体を活性化する新規生理活性ペプチド
Books (1)：
  • 「解明」から「制御」へ,肥満症のメディカルサイエンス
    羊土社 2016
Lectures and oral presentations  (5)：
  • Effect of PPARγ-K107 SUMOylation on insulin sensitivity and adiposity in mice.
    (The 97th Annual Meeting of the Japanese Pharmacological Society 2023)
  • 摂食同調後の給餌によるFGF15発現量低下機構の解明
    (第44回胆汁酸研究会 2023)
  • Effect of PPARγ-K107 SUMOylation on insulin sensitivity and adiposity in mice
    (日本レチノイド研究会 第33回学術集会 2022)
  • INHIBITION OF GUANYLYL CYCLASE-B ACTIVITY BY S1P IS MEDIATED THROUGH S1P2/RHO- and S1P3/RHO-DEPENDENT PATHWAYS
    (The 95th Annual Meeting of the Japanese Pharmacological Society 2022)
  • Hepatic uptake of conjugated bile acids mediated by both NTCP and OATPs is repressed by intestinal sensing of plasma bile acid levels.
    (67th Annual Meeting of the American Association-for-the-Study-of-Liver-Diseases 2016)
Education (4)：
  • 1993 - 1996 Tokyo Institute of Technology 生命理工学研究科 バイオサイエンス専攻
  • 1993 - 1996 Tokyo Institute of Technology 生命理工学研究科 バイオサイエンス専攻
  • 1991 - 1993 Tokyo Institute of Technology 理工学研究科 科学専攻
  • 1987 - 1991 Tokyo Institute of Technology 理学部 生命理学科
Professional career (1)：
  • 博士(理学) (東京工業大学)
Work history (3)：
  • 2018/10 - 2019/12 University of Texas Southwestern Medical Center Department of Neuroscience Instructor
  • 2008/06 - 2018/09 University of Texas Southwestern Medical Center Department of Pharmacology Instructor
  • 1996/04 - 2008/05 National Cardiovascular Center Research Institute
Awards (1)：
  • 2002/11 - The Society of Cardiovascular Endocrinology and Metabolism Young Investigator Award
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