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J-GLOBAL ID：202002210931995334   Reference number：20A1159972

Early Transplantation of Human Cranial Bone-derived Mesenchymal Stem Cells Enhances Functional Recovery in Ischemic Stroke Model Rats

ヒト頭蓋骨由来間葉系幹細胞の早期移植が虚血性脳卒中モデルラットの機能回復を強化する

Author (14)： OSHITA Jumpei (Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  OKAZAKI Takahito (Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  MITSUHARA Takafumi (Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  IMURA Takeshi (Division of Bio-Environmental Adaptation Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  NAKAGAWA Kei (Division of Bio-Environmental Adaptation Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  OTSUKA Takashi (Division of Bio-Environmental Adaptation Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  KUROSE Tomoyuki (Division of Bio-Environmental Adaptation Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  TAMURA Takayuki (Department of Radiology, Hiroshima University Hospital) ,  ABIKO Masaru (Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  TAKEDA Masaaki (Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  KAWAHARA Yumi (Space Bio-Laboratories Co., Ltd.) ,  YUGE Louis (Division of Bio-Environmental Adaptation Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  YUGE Louis (Space Bio-Laboratories Co., Ltd.) ,  KURISU Kaoru (Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University)
Material： Neurologia Medico-Chirurgica  (神経外科)
Volume： 60  Issue： 2  Page： 83-93(J-STAGE)  Publication year： 2020 
JST Material Number： Z0762A  ISSN： 0470-8105  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： BDNF ,...

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Author keywords (5)： mesenchymal stem cell ,  cranial bone ,  transplantation ,  stroke ,  vascular disorders

JST classification (1)： Basic neurology  (GN01020W)

Reference (49)：

• 1) Li Y, Chen J, Chen XG, et al.: Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery. Neurology 59: 514-523, 2002
• 2) Kang SK, Lee DH, Bae YC, Kim HK, Baik SY, Jung JS: Improvement of neurological deficits by intracerebral transplantation of human adipose tissue-derived stromal cells after cerebral ischemia in rats. Exp Neurol 183: 355-366, 2003
• 3) Nomura T, Honmou O, Harada K, Houkin K, Hamada H, Kocsis JD: I.V. infusion of brain-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat. Neuroscience 136: 161-169, 2005
• 4) Horita Y, Honmou O, Harada K, Houkin K, Hamada H, Kocsis JD: Intravenous administration of glial cell line-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in the adult rat. J Neurosci Res 84: 1495-1504, 2006
• 5) Liu H, Honmou O, Harada K, et al.: Neuroprotection by PIGF gene-modified human mesenchymal stem cells after cerebral ischaemia. Brain 129: 2734-2745, 2006

Terms in the title (9)： ヒト ,  頭蓋骨 ,  間葉系幹細胞 ,  早期 ,  移植 ,  虚血性脳卒中 ,  モデルラット ,  機能回復 ,  強化