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J-GLOBAL ID：202002211826022092   Reference number：20A0572198

Analysis of Proline Substitutions Reveals the Plasticity and Sequence Sensitivity of Human IAPP Amyloidogenicity and Toxicity

プロリン置換の分析はヒトIAPPアミロイド原性と毒性の可塑性と配列感受性を明らかにする【JST・京大機械翻訳】

Author (8)： Ridgway Zachary (Department of Chemistry, Stony Brook University, New York, United States) ,  Eldrid Charles (Institute of Structural and Molecular Biology, University College London, U.K.) ,  Zhyvoloup Alexander (Institute of Structural and Molecular Biology, University College London, U.K.) ,  Ben-Younis Aisha (Institute of Structural and Molecular Biology, University College London, U.K.) ,  Noh Daeun (Graduate Program in Biochemistry and Structural Biology, Stony Brook University, New York, United States) ,  Thalassinos Konstantinos (Institute of Structural and Molecular Biology, University College London, U.K.) ,  Raleigh Daniel P. (Department of Chemistry, Stony Brook University, New York, United States) ,  Raleigh Daniel P. (Institute of Structural and Molecular Biology, University College London, U.K.)
Material： Biochemistry
Volume： 59  Issue： 6  Page： 742-754  Publication year： 2020 
JST Material Number： B0270B  ISSN： 0006-2960  CODEN： BICHAW  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Pancreatic amyloid formation b...

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Thesaurus term： steric conformation ,  Type 2 diabetes mellitus ,  in vitro experiment ,  polypeptide ,  solubility (property) ,  monomer ,  Rattus ,  *plasticity ,  dimer ,  sensitivity ,  *human ,  *Amyloid ,  analogical material ,  Diabetes Mellitus ,  Myomorpha ,  *mechanical property ,  *property ,  *Proteins ,  *glycoprotein ,  *animal protein ,  amino acid ,  nitrogen heterocyclic compound

JST classification (1)： Metabolic diseases,nutritional diseases in general.  (GD05010J)

Substance index (1)： Proline

Terms in the title (9)： プロリン ,  置換 ,  分析 ,  ヒト ,  IAPP ,  アミロイド ,  毒性 ,  可塑性 ,  感受性