Art

J-GLOBAL ID：202002212333455806   Reference number：20A0138789

Formation of Indomethacin-Saccharin Cocrystals during Wet Granulation: Role of Polymeric Excipients

湿式造粒中のインドメタシン-サッカリン共結晶の形成:高分子賦形剤の役割【JST・京大機械翻訳】

Author (8)： Tanaka Ryoma (Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minnesota, United States) ,  Tanaka Ryoma (Graduate School of Pharmaceutical Sciences, Musashino University) ,  Duggirala Naga Kiran (Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minnesota, United States) ,  Hattori Yusuke (Graduate School of Pharmaceutical Sciences, Musashino University) ,  Hattori Yusuke (Research Institute of Pharmaceutical Sciences, Musashino University) ,  Otsuka Makoto (Graduate School of Pharmaceutical Sciences, Musashino University) ,  Otsuka Makoto (Research Institute of Pharmaceutical Sciences, Musashino University) ,  Suryanarayanan Raj (Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minnesota, United States)
Material： Molecular Pharmaceutics
Volume： 17  Issue： 1  Page： 274-283  Publication year： 2020 
JST Material Number： W3686A  ISSN： 1543-8384  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Formulation of a cocrystal int...

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Thesaurus term： interaction ,  shear(mechanics) ,  chemometrics ,  granule(particle) ,  rate theory ,  *macromolecule ,  solubility(property) ,  *filler(pharmaceuticals) ,  granulation ,  unit operation ,  polymer ,  solid preparation ,  aliphatic alcohol
Semi thesaurus term： *共結晶 ,  *湿式造粒 , 【Automatic Indexing@JST】

Author keywords (8)： cocrystal ,  poorly water-soluble drug ,  excipient ,  polymer ,  high-shear wet granulation ,  chemometrics ,  continuous processing ,  kinetics

JST classification (2)： Basic biopharmacy  (GY01021U) ,  Basic research of immunotherapeutic agents and blood preparations  (GW22010D)

Substance index (1)： Ethanol

Terms in the title (7)： 湿式造粒 ,  インドメタシン ,  サッカリン ,  共結晶 ,  高分子 ,  賦形剤 ,  役割