Art

J-GLOBAL ID：202002212556487922   Reference number：20A1075924

The cysteine residue at 424th of pyruvate kinase M2 is crucial for tetramerization and responsiveness to oxidative stress

ピルビン酸キナーゼM2の424時間のシステイン残基は四量化と酸化ストレスに対する応答性に重要である【JST・京大機械翻訳】

Author (8)： Masaki So (Laboratory of Molecular Medicinal Science, Department of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan) ,  Masaki So (Laboratory for Malignancy Control Research, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Hashimoto Kozue (Laboratory of Molecular Medicinal Science, Department of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan) ,  Kihara Daiki (Laboratory of Molecular Medicinal Science, Department of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan) ,  Tsuzuki Chizuru (Laboratory for Malignancy Control Research, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Kataoka Naoyuki (Laboratory for Malignancy Control Research, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Kataoka Naoyuki (Laboratory of Cellular Biochemistry, Department of Animal Resource Sciences, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan) ,  Suzuki Kenji (Laboratory of Molecular Medicinal Science, Department of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 526  Issue： 4  Page： 973-977  Publication year： 2020 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Alternative splicing of the py...

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Thesaurus term： Oxygen ,  amino acid ,  mRNA ,  glycolytic pathway ,  tumor cell ,  *Pyruvate Kinase ,  monomer ,  availability ,  dimer ,  tetramer ,  *oxidative stress ,  *cysteine residue ,  aliphatic ketone ,  aliphatic carboxylic acid ,  keto acid ,  hexose ,  aldose ,  enol ,  unsaturated carboxylic acid ,  inorganic acid ester

Author keywords (3)： Pyruvate kinase M ,  Oxidative stress ,  Splicing isoforms

JST classification (2)： Function of cell components  (EF03060C) ,  Enzyme in general  (EB09010D)

Substance index (3)： Pyruvic Acid ,  Glucose ,  Phosphoenolpyruvic acid

Terms in the title (5)： ピルビン酸キナーゼM2 ,  システイン残基 ,  四量化 ,  酸化ストレス ,  応答性