Art

J-GLOBAL ID：202002213349516433   Reference number：20A1354417

Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas

薬物動態学的可変性と肉芽腫不均一性の両方は結核肉芽腫を殺菌する第一選択抗生物質の能力に影響を与える【JST・京大機械翻訳】

Author (5)： Cicchese Joseph M. (Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, United States) ,  Dartois Veronique (Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, United States) ,  Dartois Veronique (Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, United States) ,  Kirschner Denise E. (Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States) ,  Linderman Jennifer J. (Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, United States)
Material： Frontiers in Pharmacology (Web)
Volume： 11  Page： 333  Publication year： 2020 
JST Material Number： U7091A  ISSN： 1663-9812  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Tuberculosis (TB) remains as o...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=20A1354417&from=J-GLOBAL&jstjournalNo=U7091A") }}

Thesaurus term： standardization ,  *sterilization(disinfection) ,  bacterium ,  *tuberculosis ,  *antibiotics ,  death ,  human(primates) ,  *granuloma ,  combination therapy ,  drug sensitivity ,  nitrogen heterocyclic compound ,  ether ,  fatty acid ,  macrocyclic compound ,  hydrazone ,  lactam ,  oxygen heterocyclic compound ,  polyphenol ,  bridged compound ,  polynuclear aromatic compound ,  carboxylate(ester) ,  hydroxy ketone ,  polyol ,  carboxamide ,  aliphatic amine ,  aliphatic alcohol ,  aminoalcohol ,  diamine ,  secondary amine

Author keywords (6)： agent-based model ,  pharmacokinetic/pharmacodynamic (PK/PD) model ,  multi-scale model ,  isoniazid ,  rifampin ,  tissue distribution

JST classification (2)： Infectious diseases,parasitics diseases in general.  (GD01010H) ,  Biophylaxis and immune systems in general  (ED01010F)

Substance index (4)： Isoniazide ,  Rifampin ,  Pyrazinamide ,  Ethambutol

Reference (59)：

• Bhusal Y., Shiohira C. M., Yamane N. (2005). Determination of in vitro synergy when three antimicrobial agents are combined against Mycobacterium tuberculosis. Int. J. Antimicrob. Agents 26, 292-297. doi: doi: 10.1016/j.ijantimicag.2005.05.005
• Blanc L., Sarathy J. P., Alvarez Cabrera N., O'Brien P., Dias-Freedman I., Mina M., et al. (2018). Impact of immunopathology on the antituberculous activity of pyrazinamide. J. Exp. Med. 215, 1975-1986. doi: doi: 10.1084/jem.20180518
• Blum M., Demierre A., Grant D. M., Heim M., Meyer U. A. (1991). Molecular mechanism of slow acetylation of drugs and carcinogens in humans. Proc. Natl. Acad. Sci. 88, 5237-5241. doi: doi: 10.1073/pnas.88.12.5237
• Boeree M. J., Heinrich N., Aarnoutse R., Diacon A. H., Dawson R., Rehal S., et al. (2017). High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial. Lancet Infect. Dis. 17, 39-49. doi: doi: 10.1016/S1473-3099(16)30274-2
• Bonnett L. J., Ken-dror G., Koh G. C. K. W., Davies G. R. (2017). Comparing the Efficacy of Drug Regimens for Pulmonary Tuberculosis: Meta-analysis of Endpoints in Early-Phase Clinical Trials. Clin. Infect. Dis. 65, 46-54. doi: doi: 10.1093/cid/cix247

Terms in the title (8)： 薬物動態学 ,  可変性 ,  肉芽腫 ,  不均一性 ,  結核 ,  殺菌 ,  抗生物質 ,  能力