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J-GLOBAL ID：202002215386735296   Reference number：20A0622728

Inhibitory effects of rubratoxin A, a potent inhibitor of protein phosphatase 2, on the Ca²⁺-dependent contraction of skinned carotid artery from guinea pig

モルモット由来の皮膚頸動脈のCa²⁺依存性収縮に対するタンパク質ホスファターゼ2の強力な阻害剤であるルブラトキシンAの阻害効果

Author (3)： Naraki Yasuyuki (Department of Frontier Health Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, 7-2-10 Higashiogu, Arakawa-ku, Tokyo 116-8551, Japan) ,  Watanabe Masaru (Department of Frontier Health Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, 7-2-10 Higashiogu, Arakawa-ku, Tokyo 116-8551, Japan) ,  Takeya Kosuke (Department of Veterinary Biochemistry, Faculty of Veterinary Medicine, Okayama University of Science, Imabari-shi, Ehime 794-8555, Japan)
Material： Journal of Smooth Muscle Research (Web)  (J Smooth Muscle Res (Web))
Volume： 55  Page： 14-22(J-STAGE)  Publication year： 2019 
JST Material Number： U0411A  ISSN： 1884-8796  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mycotoxin ,...
Semi thesaurus term： rubratoxin ,...

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Author keywords (5)： vascular smooth muscle ,  protein phosphatase 2A ,  rubratoxin A ,  Ca²⁺ sensitivity ,  contractile proteins

JST classification (3)： Vasculature  (EJ04030O) ,  Muscles  (EJ10020G) ,  Enzyme in general  (EB09010D)

Substance index (1)： Rubratoxin A

Reference (25)：

• 1. Somlyo, AP, Somlyo, AV. Ca²⁺ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev. 2003; 83(4): 1325-58.
• 2. Hartshorne, DJ, Ito, M, Erdödi, F. Role of protein phosphatase type 1 in contractile functions: myosin phosphatase. J Biol Chem. 2004; 279(36): 37211-4.
• 3. Hori, M, Magae, J, Han, YG, Hartshorne, DJ, Karaki, H. A novel protein phosphatase inhibitor, tautomycin. Effect on smooth muscle. FEBS Lett. 1991; 285(1): 145-8.
• 4. Gong, MC, Cohen, P, Kitazawa, T, Ikebe, M, Masuo, M, Somlyo, AP, Somlyo, AV. Myosin light chain phosphatase activities and the effects of phosphatase inhibitors in tonic and phasic smooth muscle. J Biol Chem. 1992; 267(21): 14662-8.
• 5. Butler, T, Paul, J, Europe-Finner, N, Smith, R, Chan, EC. Role of serine-threonine phosphoprotein phosphatases in smooth muscle contractility. Am J Physiol Cell Physiol. 2013; 304(6): C485-504.

Terms in the title (9)： モルモット ,  皮膚 ,  頸動脈 ,  依存性 ,  収縮 ,  タンパク質ホスファターゼ2 ,  阻害剤 ,  ルブラトキシンA ,  阻害効果