Art

J-GLOBAL ID：202002215452340685   Reference number：20A0583411

Exposure of Pancreatic β-Cells to Excess Glucose Results in Bimodal Activation of mTORC1 and mTOR-Dependent Metabolic Acceleration

過剰グルコースに対する膵臓β細胞の曝露はmTORC1およびmTOR依存性代謝促進の二峰性活性化をもたらす【JST・京大機械翻訳】

Author (7)： Rumala Courtney Zasha (Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA) ,  Liu Juan (Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Duke University, Durham, NC 27710, USA) ,  Locasale Jason Wei (Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Duke University, Durham, NC 27710, USA) ,  Corkey Barbara Ellen (Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA) ,  Deeney Jude Thaddeus (Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA) ,  Rameh Lucia Egydio (Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA) ,  Rameh Lucia Egydio (Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA)
Material： iScience
Volume： 23  Issue： 2  Page： Null  Publication year： 2020 
JST Material Number： W5512A  ISSN： 2589-0042  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Chronic exposure of pancreatic...

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Thesaurus term： mitochondria ,  energy demand ,  cellular signal transduction ,  phosphatidylinositol 3-kinase ,  reconstitution ,  glycolysis ,  *excitometabolism ,  metabolic pathway ,  aliphatic ketone ,  aliphatic carboxylic acid ,  keto acid
Semi thesaurus term： 分子機構 ,  インスリン分泌 ,  AMP活性化蛋白質キナーゼ ,  慢性曝露 ,  *mTORC1 ,  *インスリン分泌細胞 , 【Automatic Indexing@JST】

Author keywords (4)： Molecular Mechanism of Behavior ,  Endocrinology ,  Diabetology ,  Specialized Functions of Cells

JST classification (1)： Cell physiology in general  (EF02010S)

Substance index (1)： Pyruvic Acid

Terms in the title (8)： グルコース ,  膵臓β細胞 ,  曝露 ,  mTORC1 ,  mTOR ,  依存性 ,  代謝促進 ,  活性化