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J-GLOBAL ID：202002216083416033   Reference number：20A1870206

Social defeat stress exacerbates atopic dermatitis through downregulation of DNA methyltransferase 1 and upregulation of C-C motif chemokine receptor 7 in skin dendritic cells

皮膚樹状細胞におけるDNAメチルトランスフェラーゼ1の下方制御とC-Cモチーフケモカイン受容体7のアップレギュレーションを通してアトピー性皮膚炎を悪化させる社会的敗北ストレス【JST・京大機械翻訳】

Author (22)： Yoshida Yuko (Department of Pharmaceutical Sciences, Musashino University, Tokyo, 202-8585, Japan) ,  Yoshida Yuko (Institute for Environment and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, 279-0021, Japan) ,  Hayakawa Kunihiro (Institute for Environment and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, 279-0021, Japan) ,  Fujishiro Maki (Institute for Environment and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, 279-0021, Japan) ,  Ikeda Keigo (Institute for Environment and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, 279-0021, Japan) ,  Ikeda Keigo (Department of Internal Medicine and Rheumatology, Juntendo University, Urayasu Hospital, Chiba, 279-0021, Japan) ,  Tsushima Hiroshi (Institute for Environment and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, 279-0021, Japan) ,  Tsushima Hiroshi (Department of Internal Medicine and Rheumatology, Juntendo University, Urayasu Hospital, Chiba, 279-0021, Japan) ,  Hirai Takuya (Institute for Environment and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, 279-0021, Japan) ,  Hirai Takuya (Department of Internal Medicine and Rheumatology, Juntendo University, Urayasu Hospital, Chiba, 279-0021, Japan) ,  Kawasaki Mikiko (Institute for Environment and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, 279-0021, Japan) ,  Tominaga Mitsutoshi (Institute for Environment and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, 279-0021, Japan) ,  Tominaga Mitsutoshi (Juntendo Itch Research Center, Institute for Environment and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, 279-0021, Japan) ,  Suga Yasushi (Department of Dermatology, Juntendo University, Urayasu Hospital, Chiba, 279-0021, Japan) ,  Takamori Kenji (Institute for Environment and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, 279-0021, Japan) ,  Takamori Kenji (Juntendo Itch Research Center, Institute for Environment and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, 279-0021, Japan) ,  Takamori Kenji (Department of Dermatology, Juntendo University, Urayasu Hospital, Chiba, 279-0021, Japan) ,  Watanabe Yoshifumi (Department of Pharmaceutical Sciences, Musashino University, Tokyo, 202-8585, Japan) ,  Sekigawa Iwao (Institute for Environment and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, 279-0021, Japan) ,  Sekigawa Iwao (Department of Internal Medicine and Rheumatology, Juntendo University, Urayasu Hospital, Chiba, 279-0021, Japan) ,  Morimoto Shinji (Institute for Environment and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, 279-0021, Japan) ,  Morimoto Shinji (Department of Internal Medicine and Rheumatology, Juntendo University, Urayasu Hospital, Chiba, 279-0021, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 529  Issue： 4  Page： 1073-1079  Publication year： 2020 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： DNA methylation is an epigenet...

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Thesaurus term： Methylation ,  gene ,  Bone Marrow ,  ointment ,  human ,  *Dermatitis ,  Pruritus ,  *dendritic cell ,  pathological state ,  *Up-Regulation ,  pathogenesis ,  *Chemokine Receptors ,  DNA Methylation ,  CpG ,  PBMCs

Author keywords (6)： Atopic dermatitis ,  C-C motif Chemokine receptor 7 ,  Dendritic cell ,  DNA methyltransferase 1 ,  Itch ,  Social defeat stress

JST classification (4)： Cell physiology in general  (EF02010S) ,  Function of cell components  (EF03060C) ,  Skin diseases  (GF03000Q) ,  Gene expression  (EC02040Q)

Terms in the title (9)： 皮膚樹状細胞 ,  DNAメチルトランスフェラーゼ1 ,  下方制御 ,  モチーフ ,  ケモカイン受容体 ,  アップレギュレーション ,  アトピー性皮膚炎 ,  悪化 ,  社会的敗北ストレス