Art

J-GLOBAL ID：202002216235994906   Reference number：20A1357141

Prolyl Isomerase Pin1 in Human Cancer: Function, Mechanism, and Significance

ヒト癌におけるプロリルイソメラーゼPin1:機能,機構および重要性【JST・京大機械翻訳】

Author (3)： Pu Wenchen (Laboratory of Molecular Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Collaborative Innovation Center of Biotherapy, Chengdu, China) ,  Zheng Yuanyuan (Laboratory of Molecular Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Collaborative Innovation Center of Biotherapy, Chengdu, China) ,  Peng Yong (Laboratory of Molecular Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Collaborative Innovation Center of Biotherapy, Chengdu, China)
Material： Frontiers in Cell and Developmental Biology (Web)
Volume： 8  Page： 168  Publication year： 2020 
JST Material Number： U7062A  ISSN： 2296-634X  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Peptidyl-prolyl cis-trans isom...

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Thesaurus term： enzyme ,  isomerization ,  conformational transition ,  substrate (biochemistry) ,  Cytoplasm ,  tumor ,  tumor cell ,  *human ,  phosphorylation ,  biological activity ,  proteolysis ,  *Peptidylprolyl Isomerase ,  *Pin1 ,  overexpression
Semi thesaurus term： 癌治療 , 【Automatic Indexing@JST】

Author keywords (5)： Pin1 ,  PPIase isomerase ,  phosphorylation ,  cis-trans isomerization ,  cancer hallmarks

JST classification (3)： Enzyme in general  (EB09010D) ,  Cell physiology in general  (EF02010S) ,  Basic oncology in general  (GE02010R)

Reference (136)：

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• Atkinson G. P., Nozell S. E., Harrison D. K., Stonecypher M. S., Chen D., Benveniste E. N. (2009). The prolyl isomerase Pin1 regulates the NF-kappaB signaling pathway and interleukin-8 expression in glioblastoma. Oncogene 28 3735-3745. doi: 10.1038/onc.2009.232
• Barber K. W., Muir P., Szeligowski R. V., Rogulina S., Gerstein M., Sampson J. R., et al (2018). Encoding human serine phosphopeptides in bacteria for proteome-wide identification of phosphorylation-dependent interactions. Nat. Biotechnol. 36 638-644. doi: 10.1038/nbt.4150
• Barman A., Hamelberg D. (2016). Coupled dynamics and entropic contribution to the allosteric mechanism of Pin1. J. Phys. Chem. B 120 8405-8415. doi: 10.1021/acs.jpcb.6b02123

Terms in the title (5)： ヒト ,  癌 ,  プロリルイソメラーゼ ,  Pin1 ,  重要性