Art

J-GLOBAL ID：202002216537804745   Reference number：20A2649605

An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping

神経内分泌新生物のオルガノイドバイオバンクは遺伝子型-表現型マッピングを可能にする【JST・京大機械翻訳】

Author (49)： Kawasaki Kenta (Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Kawasaki Kenta (Department of Gastroenterology, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Toshimitsu Kohta (Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Toshimitsu Kohta (Department of Gastroenterology, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Matano Mami (Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Fujita Masashi (Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan) ,  Fujii Masayuki (Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Fujii Masayuki (Deparment of Surgical Oncology, The University of Tokyo, Tokyo 113-8654, Japan) ,  Togasaki Kazuhiro (Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Togasaki Kazuhiro (Department of Gastroenterology, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Ebisudani Toshiki (Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Ebisudani Toshiki (Department of Pulmonary Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Shimokawa Mariko (Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Takano Ai (Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Takahashi Sirirat (Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Ohta Yuki (Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Nanki Kosaku (Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Nanki Kosaku (Department of Gastroenterology, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Igarashi Ryo (Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Igarashi Ryo (Department of Gastroenterology, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Ishimaru Kazuhiro (Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Ishimaru Kazuhiro (Deparment of Surgical Oncology, The University of Tokyo, Tokyo 113-8654, Japan) ,  Ishida Hiroki (Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Ishida Hiroki (Department of Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Sukawa Yasutaka (Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Sukawa Yasutaka (Department of Gastroenterology, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Sugimoto Shinya (Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Sugimoto Shinya (Department of Gastroenterology, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Saito Yoshimasa (Department of Gastroenterology, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Saito Yoshimasa (Division of Pharmacotherapeutics, Keio University Faculty of Pharmacy, Tokyo 105-8512, Japan) ,  Maejima Kazuhiro (Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan) ,  Sasagawa Shota (Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan) ,  Lee Hwajin (Biomedical Knowledge Engineering Laboratory, Seoul National University, Seoul 08826, South Korea) ,  Kim Hong-Gee (Biomedical Knowledge Engineering Laboratory, Seoul National University, Seoul 08826, South Korea) ,  Ha Kyungsik (Biomedical Knowledge Engineering Laboratory, Seoul National University, Seoul 08826, South Korea) ,  Hamamoto Junko (Department of Pulmonary Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Fukunaga Koichi (Department of Pulmonary Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Maekawa Aya (Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan) ,  Tanabe Minoru (Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan) ,  Ishihara Soichiro (Deparment of Surgical Oncology, The University of Tokyo, Tokyo 113-8654, Japan) ,  Hamamoto Yasuo (Department of Gastroenterology, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Yasuda Hiroyuki (Department of Pulmonary Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Sekine Shigeki (Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo 104-0045, Japan) ,  Kudo Atsushi (Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan) ,  Kitagawa Yuko (Department of Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Kanai Takanori (Department of Gastroenterology, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Nakagawa Hidewaki (Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan) ,  Sato Toshiro (Department of Organoid Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Sato Toshiro (Department of Gastroenterology, Keio University School of Medicine, Tokyo 160-8582, Japan)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 183  Issue： 5  Page： 1420-1435.e21  Publication year： 2020 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Gastroenteropancreatic (GEP) n...

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Thesaurus term： *Heredity ,  *Genotype ,  chromosome ,  Colon ,  *tumor ,  epithelium ,  *Phenotype ,  *Neurosecretion ,  transcription factor ,  *Organoid ,  Transcriptome analysis ,  genome alignment ,  Stem Cell Niche ,  overexpression ,  Genetic Variation ,  membrane and film ,  histomembrane
Semi thesaurus term： genetic variation , 【Automatic Indexing@JST】

Author keywords (10)： CRISPR-Cas9 ,  NKX2-5 ,  gastrinoma ,  3D culture ,  lineage reprogramming ,  epigenome ,  stem cell niche ,  transcription factors ,  fusion gene ,  multi-omics

JST classification (2)： Cell physiology in general  (EF02010S) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Terms in the title (5)： 神経内分泌 ,  新生物 ,  遺伝子型 ,  表現型 ,  マッピング