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J-GLOBAL ID：202002216785834735   Reference number：20A0574760

A Genetic Variant in the BCL2 Gene Associates with Adalimumab Response in Hidradenitis Suppurativa Clinical Trials and Regulates Expression of BCL2

BCL2遺伝子における遺伝的変異体はHidradenitis suppurativa臨床試験におけるアダリムマブ応答と関連し,BCL2の発現を調節する【JST・京大機械翻訳】

Author (11)： Liu Mohan (Pharmacogenetics, Human Genetics, and Computational Genomics, Genomics Research Center, AbbVie Inc., North Chicago, IL, USA) ,  Degner Jacob (Pharmacogenetics, Human Genetics, and Computational Genomics, Genomics Research Center, AbbVie Inc., North Chicago, IL, USA) ,  Georgantas Robert W. (Pharmacogenetics, Human Genetics, and Computational Genomics, Genomics Research Center, AbbVie Inc., North Chicago, IL, USA) ,  Nader Ahmed (Clinical Pharmacology and Pharmacometrics, AbbVie Inc., North Chicago, IL, USA) ,  Mostafa Nael M. (Clinical Pharmacology and Pharmacometrics, AbbVie Inc., North Chicago, IL, USA) ,  Teixeira Henrique D. (Global Pharmaceutical Research and Development, AbbVie Inc., North Chicago, IL, USA) ,  Williams David A. (Global Pharmaceutical Research and Development, AbbVie Inc., North Chicago, IL, USA) ,  Kirsner Robert S. (Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, FL, USA) ,  Nichols Anna J. (Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, FL, USA) ,  Davis Justin Wade (Pharmacogenetics, Human Genetics, and Computational Genomics, Genomics Research Center, AbbVie Inc., North Chicago, IL, USA) ,  Waring Jeffrey F. (Pharmacogenetics, Human Genetics, and Computational Genomics, Genomics Research Center, AbbVie Inc., North Chicago, IL, USA)
Material： Journal of Investigative Dermatology  (J Invest Dermatol)
Volume： 140  Issue： 3  Page： 574-582.e2  Publication year： 2020 
JST Material Number： H0776A  ISSN： 0022-202X  CODEN： JIDEAE  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Hidradenitis suppurativa is a ...

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Thesaurus term： hair follicle ,  Europe ,  effectiveness ,  allele ,  *heredity ,  single nucleotide polymorphism ,  Genome-Wide Association Study ,  suppuration ,  genome ,  down-regulation ,  *gene ,  intron ,  Food and Drug Administration ,  gene frequency ,  *clinical trial

JST classification (4)： Gene expression  (EC02040Q) ,  Blood cell tumors(=neoplasms)  (GK04000M) ,  Molecular genetics in general  (EC02010J) ,  Basic dermatology  (GF01020Y)

Terms in the title (8)： Bcl2 ,  遺伝子 ,  遺伝的変異体 ,  臨床試験 ,  アダリムマブ ,  応答 ,  発現 ,  調節